夏岩 教授 博士 研究领域: 天然气化工,新材料,石油炼制,石油化工,精细化工,生物医药 研究方向: 新药研发、药物化学、有机化学 所在单位: 全球健康药物研究中心

基本信息

所在单位:
全球健康药物研究中心
职称:
教授
最高学历:
博士
教育经历:
1984-1989 PhD (Organic Synthesis, Advisor: Prof. A. P. Kozikowski), University of Pittsburgh, Pittsburgh, PA 15260.  Received the Andrew Mellon predoctoral fellowship from 1986-1988.
工作经历:
PROFESSIONAL EXPERIENCE
2021-now Director, Chemistry, Global Health Drug Discovery Institute (GHDDI), Beijing, China.
2020-2021 Senior VP, Preclinical, Galixir, Beijing, China.
2018-2020 Chemistry VP, Helios Huaming BioPharma, Suzhou, China.
2014-2019 Consultant, Cardiovascular Disease, Tasly, Tianjin, China.
2013-2014 Chemistry VP, Ascepion Pharmaceuticals, Suzhou, China.
2011-2016 Taishan Scholar, Medicinal and Environmental Chemistry and Biology, Qingdao University of Technology, Qingdao, China.
2009-2011 Senior Principal Scientist, Medicinal Chemistry, Infectious Diseases, Merck Research Laboratories, Kenilworth, NJ 07033.
1990-2009 Senior Principal Scientist, Cardiovascular, Metabolic & CNS Chemistry, Schering-Plough Research Institute, Kenilworth, NJ 07033.
1982-1984 Research and Teaching Faculty; Physical and Structural Organic Chemistry Laboratory, Department of Chemistry, Nankai University, Tianjin, China.

EDUCATION
1989-1990  Postdoctoral Visiting Fellow (Advisor: Dr. J. Pitha) on a Fogarty fellowship grant; Macromolecular Chemistry Section, Laboratory of Molecular and Cellular Biology, National Institute on Aging/NIH, Baltimore, MD
1978-1982  BS (Organic Chemistry), Nankai University, Tianjin, China.  Received the World Bank scholarship for graduate study.
专家介绍:
1982年南开大学化学系本科毕业,获世界银行贷款奖学金,赴美国匹兹堡大学(University of Pittsburgh)攻读有机合成博士学位。期间,获梅隆奖学金并完成天然产物石杉碱甲(Huperzine A)全合成。石杉碱甲具有治疗老年痴呆症药效。1988-1990年,在美国健康研究所(National Institutes of Health,NIH)从事环糊精衍生物在药剂应用方面的博士后研究工作。


1990-2011年,在美国大型制药公司仙灵保雅(Schering-Plough)和默克/默沙东(Merck/MSD)从事先导物优化方面的新药研发工作,任资深主任研究员。参与降血压、心血管病,糖尿病,中枢神经,肝炎等新药项目十余种。主要代表性成果有:1)抗血栓新药-凝血酶受体拮抗剂Vorapaxar,于2014年上市。2008年获爱迪生发明奖,1996、2003年二获公司科研奖。2)帕金森病新药-A2a受体拮抗剂Preladenant,完成三期临床试验。2009年获爱迪生发明奖。

科研能力

研究领域:
天然气化工,新材料,石油炼制,石油化工,精细化工,生物医药
研究方向:
新药研发、药物化学、有机化学
英文标签:
Himbacine;Thrombin Receptor Antagonist;Synthesis;Type 2 Diabetes;High-resolution Ct;Metastatic Pulmonary Calcification;Clinicopathologic Analysis;Cancer Imaging;Ct Screening;Par-1 Antagonist
论文著作:
1. Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity
Samuel Chackalamannil; Yuguang Wang; William J. Greenlee; Zhiyong Hu; Yan Xia; Ho-Sam Ahn; George Boykow; Yunsheng Hsieh; Jairam Palamanda; Jacqueline Agans-Fantuzzi; Stan Kurowski; Michael Graziano; Madhu Chintala
JOURNAL OF MEDICINAL CHEMISTRY, 2008

2. Metabolism-based Identification of a Potent Thrombin Receptor Antagonist.
Martin C. Clasby; Samuel Chackalamannil; Michael Czarniecki; Dario Doller; Keith Eagen; William Greenlee; Grace Kao; Yan Lin; Hsingan Tsai; Yan Xia; Ho-Sam Ahn; Jacqueline Agans-Fantuzzi; George Boykow; Madhu Chintala; Carolyn Foster
Journal of Medicinal Chemistry, 2006

3. Heterotricyclic Himbacine Analogs As Potent, Orally Active Thrombin Receptor (protease Activated Receptor-1) Antagonists.
Mariappan V. Chelliah; Samuel Chackalamannil; Yan Xia; Keith Eagen; Martin C. Clasby; Xiaobang Gao; William Greenlee; Ho-Sani Ahn; Jacqueline Agans-Fantuzzi; George Boykow; Yunsheng Hsieh; Matthew Bryant; Jairam Palamanda; Tze-Ming Chan; David Hesk
JOURNAL OF MEDICINAL CHEMISTRY, 2007

4. Discovery of a Nortropanol Derivative As a Potent and Orally Active GPR119 Agonist for Type 2 Diabetes
Yan Xia; Samuel Chackalamannil; William J. Greenlee; Charles Jayne; Bernard Neustadt; Andrew Stamford; Henry Vaccaro; Xiaoying (Lucy) Xu; Hana Baker; Kim O'Neill; Morgan Woods; Brian Hawes; Tim Kowalski
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011
发明专利:
1. New heterocyclic-substituted tricyclics useful for treating e.g. thrombosis, atherosclerosis, heart failure, glomerulonephritis, inflammatory disorder and cancer.
SCHERING CORP
CHACKALAMANNIL SAMUEL; CLASBY MARTIN C; GREENLEE WILLIAM J; WANG YUGUANG; XIA YAN; VELTRI ENRICO P; CHELLIAH MARIAPPAN; WU WENXUE
公开日期: 2018-07-12 申请日期: 2003-04-14 公开号: DE60317493T3

2. New substituted spirocyclic amide compounds are hepatits C virus non structural 3 protease inhibitor useful to treat hepatits C virus infection.
MERCK CANADA INC; MERCK SHARP & DOHME
AUSTIN CHEN; CHARLES JAYNE; DIPSHIKA BISWAS; DUANE BURNETTE; FRANCISCO VELAZQUEZ; HUBERT JOSIEN; KAREN MARCANTONIO; LINDA BROCKUNIER; MARIAPPAN V CHELIAH; MARTIN CLASBY; MURALI RAJAGOPALAN; PATRICK PINTO; SAMUEL CHACKALAMANNIL; SANTHOSH NEELAMKAVIL; SATHESH BHAT
公开日期: 2017-12-05 申请日期: 2013-08-06 公开号: BR112015002541A2

3. 一种灰绿霉素A及类似物的全合成方法
青岛理工大学
谭伟强; 夏岩
公开日期: 2017-06-13 申请日期: 2017-01-23 公开号: CN106831693A

4. Adenosine a2a receptor antagonists
MERCK SHARP & DOHME
NEUSTADT BERNARD R; LINDO NEIL A; GREENLEE WILLIAM J; TULSHIAN DEEN; SILVERMAN LISA S; XIA YAN; BOYLE CRAIG D; CHACKALAMANNIL SAMUEL
公开日期: 2016-05-30 申请日期: 2001-05-24 公开号: HU230420B1

5. BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF
SCHERING CORP
BOYLE CRAIG D; CHACKALAMANNIL SAMUEL; STAMFORD ANDREW W; DAI XING; NEELAMKAVIL SANTHOSH FRANCIS; SHAH UNMESH G; XIA YAN; GREENLEE WILLIAM J; JAYNE CHARLES LEE; HARRIS JOEL M; NEUSTADT BERNARD R; LANKIN CLAIRE M; LIU HONG
公开日期: 2015-12-15 申请日期: 2008-10-20 公开号: CA2703203C

6. MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS
MOCHIDA PHARM CO LTD; SCHERING CORP
NISHIDA HIDEMITSU; SAITOH FUMIHIKO; HIRABAYASHI TOMOKAZU; CHACKALAMANNIL SAMUEL; CHAN TIN-YAU; CHELLIAH MARIAPPAN V; CLASBY MARTIN C; DWYER MICHAEL P; GREENLEE WILLIAM J; XIA YAN
公开日期: 2015-11-11 申请日期: 2009-12-03 公开号: EP2373634B1

7. Cyclic amide BACE-1 inhibitors having a benzamide substituent
Pharmacopeia Drug Discovery Inc.; Merck Sharp & Dohme Corp.
Jared N. Cumming; Ulrich Iserloh; Andrew Stamford; Corey Strickland; Johannes H. Voight; Yusheng Wu; Ying Huang; Yan Xia; Samuel Chackalamannil; Tao Guo; Douglas W. Hobbs; Thuy X. H. Le; Jeffrey H. Lowrie; Kurt W. Saionz; Suresh D. Babu
公开日期: 2015-06-23 申请日期: 2014-01-06 公开号: US09062007B2

8. Cyclic amide BACE-1 inhibitors having a benzamide substituent
PHARMACOPEIA DRUG DISCOVERY; MERCK SHARP & DOHME
CUMMING JARED N; ISERLOH ULRICH; STAMFORD ANDREW; STRICKLAND COREY; VOIGHT JOHANNES H; WU YUSHENG; HUANG YING; XIA YAN; CHACKALAMANNIL SAMUEL; GUO TAO; HOBBS DOUGLAS W; LE THUY X H; LOWRIE JEFFREY H; SAIONZ KURT W; BABU SURESH D
公开日期: 2015-06-23 申请日期: 2014-01-06 公开号: US9062007B2

9. HCV NS3蛋白酶抑制剂
默沙东公司; 默克加拿大有限公司
T.巴拉; S.巴特; D.比斯瓦斯; L.布罗库尼耶; D.伯内特; S.查卡拉马尼尔; M.V.切利亚; A.陈; M.克拉斯比; V.J.科兰里; 郭竹艳; 韩永新; C.杰恩; H.乔西恩; K.马肯托尼奥
公开日期: 2015-06-17 申请日期: 2013-08-06 公开号: CN104718211A

10. HCV NS3 PROTEASE INHIBITORS.
MERCK SHARP & DOHME
XIA YAN; CHACKALAMANNIL SAMUEL; HAN YONGXIN; BROCKUNIER LINDA; GUO ZHUYAN; BARA THOMAS; JOSIEN HUBERT; BHAT SATHESH; BISWAS DIPSHIKA; CHELIAH MARIAPPAN V; COLANDREA VINCE J; JAYNE CHARLES; MARCANTONIO KAREN; MIAO SHOUWU; NEELAMKAVIL SANTHOSH
公开日期: 2015-06-03 申请日期: 2013-08-06 公开号: MX2015001765A

11. Morpholinone compounds as factor IXA inhibitors
Samuel Chackalamannil; Martin C. Clasby; Tomokazu Hirabayashi; Fumihiko Saitoh; Mariappan V. Chelliah; Michael Dwyer; Santhosh Neelamkavil; Yan Xia; Tin-Yau Chan; William J. Greenlee; Hidemitsu Nishida; Unmesh Shah
Tin-Yau Chan; Mariappan V. Chelliah; Martin C. Clasby; Michael Dwyer; Santhosh Neelamkavil; Hidemitsu Nishida; Fumihiko Saitoh; Yan Xia; Samuel Chackalamannil; William J. Greenlee; Tomokazu Hirabayashi; Unmesh Shah
公开日期: 2015-03-24 申请日期: 2010-06-01 公开号: US08987242B2

12. HCV NS3 protease inhibitors
Merck Sharp & Dohme Corp.; Merck Canada Inc.
Linda Brockunier; Austin Chen; Yongxin Han; Shouwu Miao; Unmesh Shah; Thomas Bara; Duane A. Burnett; Martin Clasby; Charles Jayne; Santhosh Neelamkavil; Francisco Velazquez; Dipshikha Biswas; Mariappan V. Chelliah; Zhuyan Guo; Karen Marcantonio
公开日期: 2015-03-24 申请日期: 2013-08-06 公开号: US08987195B2

13. Morpholinone compounds as factor IXA inhibitors
CHACKALAMANNIL SAMUEL; CHAN TIN-YAU; CHELLIAH MARIAPPAN V; CLASBY MARTIN C; DWYER MICHAEL; GREENLEE WILLIAM J; HIRABAYASHI TOMOKAZU; NEELAMKAVIL SANTHOSH; NISHIDA HIDEMITSU; SAITOH FUMIHIKO; SHAH UNMESH; XIA YAN; MERCK SHARP & DOHME; MOCHIDA PHARMACEUTICALS CO LTD
CHACKALAMANNIL SAMUEL; CHAN TIN-YAU; CHELLIAH MARIAPPAN V; CLASBY MARTIN C; DWYER MICHAEL; GREENLEE WILLIAM J; HIRABAYASHI TOMOKAZU; NEELAMKAVIL SANTHOSH; NISHIDA HIDEMITSU; SAITOH FUMIHIKO; SHAH UNMESH; XIA YAN
公开日期: 2015-03-24 申请日期: 2010-06-01 公开号: US8987242B2

14. Thrombin receptor antagonists
SCHERING CORP
CHACKALAMANNIL SAMUEL; CHELLIAH MARIAPPAN V; XIA YAN; EAGEN KEITH A
公开日期: 2015-03-04 申请日期: 2005-10-05 公开号: EP2075250B1

15. HCV NS3 protease inhibitors
MERCK SHARP & DOHME; MERCK CANADA INC
BARA THOMAS; BHAT SATHESH; BISWAS DIPSHIKA; BROCKUNIER LINDA; BURNETTE DUANE; CHACKALAMANNIL SAMUEL; CHELIAH MARIAPPAN; CHEN AUSTIN; CLASBY MARTIN; COLANDREA VINCE; GUO ZHUYAN; HAN YONGXIN; JAYNE CHARLES; JOSIEN HUBERT; MARCANTONIO KAREN
公开日期: 2015-02-05 申请日期: 2013-08-06 公开号: AU2013299807A1

16. ADENOSINE A2A RECEPTOR ANTAGONISTS
SCHERING CORP
NEUSTADT BERNARD R; LINDO NEIL A; GREENLEE WILLIAM J; TULSHIAN DEEN; SILVERMAN LISA S; XIA YAN; BOYLE CRAIG D; CHACKALAMANNIL SAMUEL
公开日期: 2015-01-30 申请日期: 2001-05-24 公开号: PL218764B1

17. Bicyclic heterocycle derivatives and their use as modulators of the activity of GPR119
Yan Xia; Craig D. Boyle; William J. Greenlee; Samuel Chackalamannil; Charles Lee Jayne
Yan Xia; Craig D. Boyle; William J. Greenlee; Samuel Chackalamannil; Charles Lee Jayne
公开日期: 2014-12-09 申请日期: 2008-10-20 公开号: US08907095B2

项目合作

合作意向:
技术咨询
在线客服 在线留言 小程序 公众号 4001789689 <<显示