新材料,石油炼制,石油化工,精细化工,生物医药

糖化学与天然产物合成

Glycosylation;Glycosylation Mechanisms;Glycopeptides;Peptides;Synthetic Methods;Glycoprotein Synthesis;Natural Products;Carbohydrate Vaccines;Native Chemical Ligation;Carbohydrate-based Drug Design

1. Free-Radical-Based, Specific Desulfurization of Cysteine: A Powerful Advance in the Synthesis of Polypeptides and Glycopolypeptides
Qian Wan; Samuel J. Danishefsky
ChemInform, 2008

2. Native Chemical Ligation at Valine: A Contribution to Peptide and Glycopeptide Synthesis
Jin Chen; Qian Wan; Yu Yuan; Jianglong Zhu; Samuel J. Danishefsky
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008

3. Preparation and Evaluation of Unimolecular Pentavalent and Hexavalent Antigenic Constructs Targeting Prostate and Breast Cancer: A Synthetic Route to Anticancer Vaccine Candidates
G Ragupathi; F Koide; PO Livingston; YS Cho; A Endo; Q Wan; MK Spassova; SJ Keding; J Allen; O Ouerfelli; RM Wilson; SJ Danishefsky
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006

4. A Program for Ligation at Threonine Sites: Application to the Controlled Total Synthesis of Glycopeptides
Jin Chen; Ping Wang; Jianglong Zhu; Qian Wan; Samuel J. Danishefsky
TETRAHEDRON, 2010

5. A Potentially Valuable Advance in the Synthesis of Carbohydrate-Based Anticancer Vaccines Through Extended Cycloaddition Chemistry.
Qian Wan; Jiehao Chen; Gong Chen; Samuel J. Danishefsky
The Journal of Organic Chemistry, 2006

6. Bone-Like Apatite Formation on Ha/316l Stainless Steel Composite Surface in Simulated Body Fluid
Fan Xin; Chen Jian; Zou Jian-peng; Wan Qian; Zhou Zhong-cheng; Ruan Jian-ming
TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA, 2009

7. From Synthesis to Biologics: Preclinical Data on A Chemistry Derived Anticancer Vaccine
Jianglong Zhu; Qian Wan; Dongjoo Lee; Guangbin Yang; Maria K. Spassova; Ouathek Ouerfelli; Govind Ragupathi; Payal Damani; Philip O. Livingston; Samuel J. Danishefsky
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009

8. Development of Efficient Methods for Accomplishing Cysteine‐Free Peptide and Glycopeptide Coupling.
Gong Chen; Qian Wan; Zhongping Tan; Cindy Kan; Zihao Hua; Krishnakumar Ranganathan; Samuel J. Danishefsky
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007

9. The Metabolic Change of Serum Lysophosphatidylcholines Involved in the Lipid Lowering Effect of Triterpenes from Alismatis Rhizoma on High-Fat Diet Induced Hyperlipidemia Mice.
Sen Li; Shuna Jin; Chengwu Song; Chang Chen; Yang Zhang; Yi Xiang; Yong Xu; Yulin Feng; Qian Wan; Hongliang Jiang
Journal of Ethnopharmacology, 2016

10. Biologics Through Chemistry: Total Synthesis of a Proposed Dual-Acting Vaccine Targeting Ovarian Cancer by Orchestration of Oligosaccharide and Polypeptide Domains
Jianglong Zhu; Qian Wan; Govind Ragupathi; Constantine M. George; Philip O. Livingston; Samuel J. Danishefsky
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009

1. GLYCOSYLATION METHOD INVOLVING TRIVALENT IODINE REAGENT
HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Qian WAN; Lingkui MENG; Jing ZENG; Yulin TAN; Yue YIN; Qin ZHANG
公开日期: 2025-03-20 申请日期: 2024-12-01 公开号: US20250092075A1

2. 一种三价碘试剂参与的糖苷化方法
华中科技大学
万谦; 孟令奎; 曾静; 谭玉林; 殷悦; 张钦
公开日期: 2023-08-08 申请日期: 2023-04-20 公开号: CN116554245A

3. 一种在水相溶剂中合成氘代化合物的方法
华中科技大学
万谦; 曾静; 宋泽金; 孟令奎
公开日期: 2021-05-11 申请日期: 2019-11-07 公开号: CN112778379A

4. 一种糖基硫醇及金诺芬的合成方法
华中科技大学
万谦; 舒朋华; 曾静; 赵岳琦
公开日期: 2016-03-23 申请日期: 2014-09-10 公开号: CN105418696A

5. HOMOGENEOUS ERYTHROPOIETIN AND METHOD FOR THEIR PREPARATION
SLOAN KETTERING INST CANCER
DANISHEFSKY SAMUEL J; WARREN J DAVID; CHEN JIEHAO; WU BIN; CHEN GONG; WAN QIAN; TAN ZHONGPING; KAN CINDY; YUAN YU; HUA ZIHAO; RANGANATHAN KRISHNAKUMAR; TRZUPEK JOHN D
公开日期: 2015-09-23 申请日期: 2007-04-11 公开号: EP2010556B1

6. Glycopeptide constructs and uses thereof
SLOAN KETTERING INST CANCER
JEON INSIK; LIVINGSTON PHILIP; LEE DONGJOO; RAGUPATHI GOVIND; WAN QIAN; ZHU JIANGLONG; KIM WOOHAN; DANISHEFSKY SAMUEL; NAGORNY PAVEL
公开日期: 2015-01-15 申请日期: 2014-12-05 公开号: AU2014271331A1

7. Glycopeptide constructs and uses thereof
SLOAN KETTERING INST CANCER
WAN QIAN; NAGORNY PAVEL; LEE DONGJOO; KIM WOOHAM; LIVINGSTON PHILIP; ZHU JIANGLONG; JEON INSIK; RAGUPATHI GOVIND; DANISHEFSKY SAMUEL
公开日期: 2014-09-18 申请日期: 2009-07-13 公开号: AU2009268349B2

8. Compositions comprising homogeneously glycosylated erythropoietin
Samuel J. Danishefsky; J. David Warren; Jiehao Chen; Bin Wu; Gong Chen; Qian Wan; Zhongping Tan; Cindy Kan; Yu Yuan; Zihao Hua; Krishnakumar Ranganathan; John D. Trzupek
Samuel J. Danishefsky; J. David Warren; Jiehao Chen; Bin Wu; Gong Chen; Qian Wan; Zhongping Tan; Cindy Kan; Yu Yuan; Zihao Hua; Krishnakumar Ranganathan; John D. Trzupek
公开日期: 2014-06-17 申请日期: 2007-04-11 公开号: US08754192B2

9. Compositions comprising homogeneously glycosylated erythropoietin
WARREN J DAVID; CHEN GONG; KAN CINDY; RANGANATHAN KRISHNAKUMAR; CHEN JIEHAO; WAN QIAN; YUAN YU; TRZUPEK JOHN D; DANISHEFSKY SAMUEL J; WU BIN; TAN ZHONGPING; HUA ZIHAO; SLOAN KETTERING INST CANCER
DANISHEFSKY SAMUEL J; CHEN JIEHAO; CHEN GONG; TAN ZHONGPING; YUAN YU; RANGANATHAN KRISHNAKUMAR; WARREN J DAVID; WU BIN; WAN QIAN; KAN CINDY; HUA ZIHAO; TRZUPEK JOHN D
公开日期: 2014-06-17 申请日期: 2007-04-11 公开号: US8754192B2

10. Electro-myocardial cardiogram (EmCG) Parameter's CSS/RSS for calculating heart performance
CHEN GUANGREN; WAN QIAN; YANG XIAOHONG
CHEN GUANGREN; WAN QIAN; YANG XIAOHONG
公开日期: 2012-11-22 申请日期: 2012-03-05 公开号: US2012296227A1

11. New multi-antigenic construct comprising cyclic peptide backbone is vaccine, useful e.g. to treat colon cancer, lung cancer, bone cancer, pancreatic cancer, stomach cancer, esophageal cancer, skin cancer and brain cancer.
LEE D; WAN Q; DANISHEFSKY S; LIVINGSTON P; ZHU J; KIM W; RAGUPATHI G; JEON I; NAGORNY P; DANISHEFSKY S J
公开日期: 2012-07-13 申请日期: 2011-10-24 公开号: HK1158213A0

12. GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF
SLOAN KETTERING INST CANCER
DANISHEFSKY SAMUEL; ZHU JIANGLONG; WAN QIAN; JEON INSIK; KIM WOOHAN; NAGORNY PAVEL; LEE DONGJOO; LIVINGSTON PHILIP; RAGUPATHI GOVIND
公开日期: 2012-02-01 申请日期: 2009-07-13 公开号: EP2315771A4

13. GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF
SLOAN KETTERING INST CANCER
DANISHEFSKY SAMUEL J; ZHU JIANGLONG; WAN QIAN; JEON INSIK; KIM WOOHAN; NAGORNY PAVEL; LEE DONGJOO; LIVINGSTON PHILIP; RAGUPATHI GOVIND
公开日期: 2011-09-22 申请日期: 2009-07-13 公开号: US2011229510A1

14. GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF
SLOAN KETTERING INST CANCER; DANISHEFSKY SAMUEL; ZHU JIANGLONG; WAN QIAN; JEON INSIK; KIM WOOHAM; NAGORNY PAVEL; LEE DONGJOO; LIVINGSTON PHILIP; RAGUPATHI GOVIND
WAN QIAN; LEE DONGJOO; ZHU JIANGLONG; NAGORNY PAVEL; DANISHEFSKY SAMUEL; KIM WOOHAM; RAGUPATHI GOVIND; JEON INSIK; LIVINGSTON PHILIP
公开日期: 2010-04-15 申请日期: 2009-07-13 公开号: WO2010006343A3

15. Homogeneous Erythropoietin and Other Peptides and Proteins, Methods and Intermediates for Their Preparation
DANISHEFSKY SAMUEL J; WARREN J DAVID; CHEN JIEHAO; WU BIN; CHEN GONG; WAN QIAN; TAN ZHONGPING; KAN CINDY; YUAN YU; HUA ZIHAO; RANGANATHAN KRISHNAKUMAR; TRZUPEK JOHN D
DANISHEFSKY SAMUEL J; WARREN J DAVID; CHEN JIEHAO; WU BIN; CHEN GONG; WAN QIAN; TAN ZHONGPING; KAN CINDY; YUAN YU; HUA ZIHAO; RANGANATHAN KRISHNAKUMAR; TRZUPEK JOHN D
公开日期: 2010-04-01 申请日期: 2007-04-11 公开号: US2010081786A1

16. GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF
SLOAN KETTERING INST CANCER
DANISHEFSKY SAMUEL; ZHU JIANGLONG; KIM WOOHAN; NAGORNY PAVEL; RAGUPATHI GOVIND; WAN QIAN; JEON INSIK; LEE DONGJOO; LIVINGSTON PHILIP
公开日期: 2010-01-14 申请日期: 2009-07-13 公开号: CA2734348A1

17. HOMOGENEOUS ERYTHROPOIETIN AND OTHER PEPTIDES AND PROTEINS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION
SLOAN KETTERING INST CANCER
TAN ZHONGPING; RANGANATHAN KRISHNAKUMAR; KAN CINDY; HUA ZIHAO; YUAN YU; CHEN GONG; WU BIN; TRZUPEK JOHN D; WAN QIAN; DANISHEFSKY SAMUEL J; CHEN JIEHAO; WARREN J DAVID
公开日期: 2007-10-25 申请日期: 2007-04-11 公开号: CA2649303A1

18. HOMOGENEOUS ERYTHROPOIETIN AND OTHER PEPTIDES AND PROTEINS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION
SLOAN KETTERING INST CANCER; DANISHEFSKY SAMUEL J; WARREN J DAVID; CHEN JIEHAO; WU BIN; CHEN GONG; WAN QIAN; TAN ZHONGPING; KAN CINDY; YUAN YU; HUA ZIHAO; RANGANATHAN KRISHNAKUMAR; TRZUPEK JOHN D
WARREN J DAVID; WU BIN; CHEN GONG; TAN ZHONGPING; YUAN YU; RANGANATHAN KRISHNAKUMAR; DANISHEFSKY SAMUEL J; CHEN JIEHAO; WAN QIAN; KAN CINDY; HUA ZIHAO; TRZUPEK JOHN D
公开日期: 2007-10-25 申请日期: 2007-04-11 公开号: WO2007120614A2

1. Interrupted Pummerer 反应在标签辅助的寡糖合成中的应用
立项时间: 2017-2020 项目经费：660000

2. 可见光促进的自由基反应在脱氧糖合成中的应用研究
立项时间: 2015-2018 项目经费：850000

3. 串联的分子内苷元传递反应（IAD）构建beta-甘露糖苷键
立项时间: 2019-2022

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