生物医药

化学生物学

General;Life Sciences;Rna Modification;Bioinformatics;Cell Biology;Biomedical Engineering/biotechnology;Mrna Modification;Biochemistry;Rna Editing;Biotechnology

1. N6-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO
Guifang Jia; Ye Fu; Xu Zhao; Qing Dai; Guanqun Zheng; Ying Yang; Chengqi Yi; Tomas Lindahl; Tao Pan; Yun-Gui Yang; Chuan He
Nature Chemical Biology, 2011

2. Selective Chemical Labeling Reveals the Genome-Wide Distribution of 5-Hydroxymethylcytosine
Chun-Xiao Song; Keith E Szulwach; Ye Fu; Qing Dai; Chengqi Yi; Xuekun Li; Yujing Li; Chih-Hsin Chen; Wen Zhang; Xing Jian; Jing Wang; Li Zhang; Timothy J Looney; Baichen Zhang; Lucy A Godley
Nature Biotechnology, 2011

3. Transcriptome-wide Mapping Reveals Reversible and Dynamic N(1)-methyladenosine Methylome.
Xiaoyu Li; Xushen Xiong; Kun Wang; Lixia Wang; Xiaoting Shu; Shiqing Ma; Chengqi Yi
Nature Chemical Biology, 2016

4. Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome
Xiaoyu Li; Ping Zhu; Shiqing Ma; Jinghui Song; Jinyi Bai; Fangfang Sun; Chengqi Yi
Nature chemical biology, 2015

5. Oxidative Demethylation of 3‐methylthymine and 3‐methyluracil in Single‐stranded DNA and RNA by Mouse and Human FTO
Guifang Jia; Cai-Guang Yang; Shangdong Yang; Xing Jian; Chengqi Yi; Zhiqiang Zhou; Chuan He
FEBS LETTERS, 2008

6. Efficient and quantitative high-throughput tRNA sequencing
Guanqun Zheng; Yidan Qin; Wesley C Clark; Qing Dai; Chengqi Yi; Chuan He; Alan M Lambowitz; Tao Pan
Nature Methods, 2015

7. Base-Resolution Mapping Reveals Distinct M1a Methylome in Nuclear- and Mitochondrial-Encoded Transcripts.
Xiaoyu Li; Xushen Xiong; Meiling Zhang; Kun Wang; Ying Chen; Jun Zhou; Yuanhui Mao; Jia Lv; Danyang Yi; Xiao-Wei Chen; Chu Wang; Shu-Bing Qian; Chengqi Yi
Molecular Cell, 2017

8. Crystal Structures of DNA/RNA Repair Enzymes AlkB and ABH2 Bound to Dsdna
Cai-Guang Yang; Chengqi Yi; Erica M. Duguid; Christopher T. Sullivan; Xing Jian; Phoebe A. Rice; Chuan He
Nature, 2008

9. Epitranscriptome Sequencing Technologies: Decoding RNA Modifications
Xiaoyu Li; Xushen Xiong; Chengqi Yi
Nature Methods, 2017

10. Landscape and Regulation of M6a and M6am Methylome Across Human and Mouse Tissues
Jun'e Liu; Kai Li; Jiabin Cai; Mingchang Zhang; Xiaoting Zhang; Xushen Xiong; Haowei Meng; Xizhan Xu; Zhibin Huang; Jinying Peng; Jia Fan; Chengqi Yi
Molecular Cell, 2019

1. 用于检测N6-甲基腺嘌呤的方法及试剂盒
北京大学
伊成器; 孙含笑
公开日期: 2025-05-27 申请日期: 2025-01-26 公开号: CN120041537A

2. METHOD AND KIT FOR DETECTING N6-METHYLADENINE IN NUCLEIC ACID MOLECULES
Peking University
Chengqi YI; Jing WANG
公开日期: 2025-01-23 申请日期: 2021-11-12 公开号: US20250027136A1

3. METHOD AND KIT FOR DETECTING EDITING SITES OF BASE EDITOR
PEKING UNIVERSITY
Chengqi YI; Zhixin LEI; Haowei MENG; Zhicong LYU
公开日期: 2024-08-15 申请日期: 2022-05-20 公开号: US20240271204A1

4. COMPOSITIONS, SYSTEMS AND METHODS OF RNA EDITING USING DKC1
Modit Therapeutics Beijing Limited
Meifang ZHANG; Chengqi YI
公开日期: 2024-07-18 申请日期: 2022-05-26 公开号: US20240238394A1

5. METHOD AND KIT FOR DETECTING N6-METHYLADENOSINE IN NUCLEIC ACID MOLECULES
Peking University
YI Chengqi; WANG Jing
公开日期: 2024-04-17 申请日期: 2021-11-12 公开号: EP4353832A1

6. COMPOSITIONS, SYSTEMS AND METHODS OF RNA EDITING USING DKC1
Modit Therapeutics Beijing Limited
ZHANG Meifang; YI Chengqi
公开日期: 2024-04-10 申请日期: 2022-05-26 公开号: EP4347834A1

7. New polypeptide or its mutant having double-stranded DNA deaminase activity comprising wild-type double-stranded DNA deaminase useful in preparing kit for editing target nucleotide sequence or for editing target nucleotide sequence.
YI C; LEI Z; MENG H; LIU L; ZHAO H
公开日期: 2023-11-02 申请日期: 2023-04-13 公开号: WO2023207607A1

8. 用于检测碱基编辑器编辑位点的方法和试剂盒
北京大学
伊成器; 孟浩巍; 吕志聪; 雷芷芯
公开日期: 2022-11-25 申请日期: 2022-05-20 公开号: CN115386623A

9. Detecting editing site, editing efficiency or off-target effect of base editor editing target nucleic acid by providing base editor editing target nucleic acid editing product, generating single-strand break nick, enriching labeled product.
YI C; LEI Z; MENG H; LYU Z; LV Z
公开日期: 2022-11-24 申请日期: 2022-05-20 公开号: WO2022242739A1

10. 检测核酸分子中N6-甲基腺嘌呤的方法及试剂盒
北京大学
伊成器; 王晶
公开日期: 2022-09-02 申请日期: 2021-11-12 公开号: CN114317704B

11. 一种病原体宏转录组测序文库的制备方法、试剂盒及筛选感染病原体的方法和装置
北京大学; 中国科学院武汉病毒研究所
伊成器; 刘翟
公开日期: 2022-06-21 申请日期: 2020-12-21 公开号: CN114645330A

12. 检测核酸分子中N6-甲基腺嘌呤的方法及试剂盒
北京大学
伊成器; 王晶
公开日期: 2022-04-12 申请日期: 2021-11-12 公开号: CN114317704A

13. TALE RVD SPECIFICALLY RECOGNIZING DNA BASE MODIFIED BY METHYLATION AND APPLICATION THEREOF
PEKING UNIVERSITY; EDIGENE INC.
Chengqi YI; Chenxu ZHU; Yuan ZHANG; Lulu LIU; Wensheng WEI; Shengjie GUO
公开日期: 2021-02-25 申请日期: 2017-08-04 公开号: US20210054030A1

14. New isolated DNA binding polypeptide useful for preparing reagent for detecting methylated base in target gene sequence, and performing gene editing of gene of interest in cell, comprises transcription activator-like effectors.
YI C; GUO S; LIU L; WEI W; ZHANG Y; ZHU C
公开日期: 2020-11-05 申请日期: 2017-08-04 公开号: JP2020531572W

15. 特异性识别甲基化修饰DNA碱基的TALE RVD及其应用
北京大学; 博雅辑因（北京）生物科技有限公司
魏文胜; 伊成器; 张媛; 郭生杰; 朱晨旭; 刘璐璐
公开日期: 2020-06-12 申请日期: 2017-08-04 公开号: CN111278848A

16. METHOD FOR MARKING 5-FORMYL CYTOSINE AND USE THEREOF IN SINGLE BASE RESOLUTION SEQUENCING
PEKING UNIVERSITY
Chengqi YI; Chenxu ZHU; Bo XIA
公开日期: 2020-05-28 申请日期: 2018-02-26 公开号: US20200165661A1

17. 5-formylcytosine specific chemical labeling method and related applications
PEKING UNIVERSITY
Chengqi Yi; Bo Xia; Ankun Zhou
公开日期: 2019-12-31 申请日期: 2014-09-26 公开号: US10519184B2

18. 5-醛基胞嘧啶的标记方法及其在单碱基分辨率测序中的应用
UNIV BEIJING
YI CHENGQI; ZHU CHENXU; XIA BO
公开日期: 2018-09-07 申请日期: 2018-02-26 公开号: WO2018157775A1

19. 5‑醛基胞嘧啶的标记方法及其在单碱基分辨率测序中的应用
UNIV BEIJING
ZHU CHENXU; YI CHENGQI; XIA BO
公开日期: 2017-07-18 申请日期: 2017-02-28 公开号: CN106957350A

20. 5-FORMYLCYTOSINE SPECIFIC CHEMICAL LABELING METHOD AND RELATED APPLICATIONS
UNIV BEIJING
YI CHENGQI; XIA BO; ZHOU ANKUN
公开日期: 2016-12-15 申请日期: 2014-09-26 公开号: US2016362438A1

1. 新型DNA表观遗传修饰检测技术的开发及在体细胞重编程研究中的应用
立项时间: 2016-2016 项目经费：750000

2. 基于生物化学交联技术的碱基切除DNA修复通路的机制与功能研究
立项时间: 2013-2016 项目经费：800000

3. 顺铂修饰DNA全基因组测序新方法及其在顺铂抗肿瘤分子机制研究中的应用
立项时间: 2015-2018 项目经费：950000

4. 精准碱基编辑的化学生物学研究
立项时间: 2023

5. 化学新前沿学术研讨会
立项时间: 2019-2019

6. 新型表观遗传修饰—1-甲基腺嘌呤（m1A)和2'-氧甲基修饰(Nm)的功能和机制研究
立项时间: 2019-2021

7. 金属配合物导致基因组化学修饰的测序技术开发和分布规律解析
立项时间: 2020-2023

8. 非编码RNA化学修饰检测新技术的发展及应用
立项时间: 2018-2020

9. 核酸化学生物学
立项时间: 2019-2023

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