相关文献：
1. Wang, F.; Zhang,W.-H.; Zhao, J.; Kang, W.-J.; Wang, S.; Yu, B.; Pan, H.-X.*; Tang, G.-L.* Characterization of miharamycin biosynthesis reveals a hybrid NRPS-PKS to synthesize high-carbon sugar from a complex nucleoside. J. Am. Chem. Soc. 2020, 142, 10.1021/jacs.0c01778.
2. Jin, W.-B.; Wu, S.; Xu, Y.-F.; Yuan, H.*; Tang, G.-L.* Recent advances in HemN-like radicalS-adenosyl-L-methionine enzyme-catalyzed reactions. Nat. Prod. Rep. 2020, 37, 17-28.
3. Ji, Z.-Y.; Nie, Q.-Y.; Yin, Y.; Zhang, M.; Pan, H.-X.; Hou, X.-F.*; Tang, G.-L.* Activation and characterization of cryptic gene cluster: Two series of aromatic polyketides biosynthesized by divergent pathways. Angew. Chem. Int. Ed. 2019, 58, 18046-18054.
4. Zhang, Y.; Wen, W.-H.; Pu, J.-Y.; Tang, M.-C.; Zhang, L.; Pen, C.; Xu, Y.; Tang, G.-L.* Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 11232–11237.
5. Hou, X.-F.; Song, Y.-J.; Zhang, M.; Lan, W.; Meng, S.; Wang, C.; Pan, H.-X.; Cao, C.*; Tang, G.-L.* Enzymology of anthraquinone-g-pyrone ring formation in complex aromatic polyketide biosynthesis. Angew. Chem. Int. Ed. 2018, 57, 13475-13479.
6. Jin, W.-B.; Wu, S.; Jian, X.-H.; Yuan, H.*; Tang, G.-L.* A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis. Nat. Commun. 2018, 9, 2771.
7. Meng, S.; Han, W.; Zhao, J.; Jian, X.-H.; Pan, H.-X.*; Tang, G.-L.* A six-oxidase cascade for tandem C-H bond activation revealed by reconstitution of bicyclomycin biosynthesis. Angew. Chem. Int. Ed. 2018, 57, 719-723.
8. Yuan, H.; Zhang, J.; Cai, Y.; Wu, S.; Yang, K.; Stephen Chan, H. C.; Huang, W.; Jin, W.-B.; Li, Y.; Yin, Y.; Igarashi, Y.; Yuan, S.*; Zhou, J.*; Tang, G.-L.* GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection. Nat. Commun. 2017, 8, 1485.
9. Song, L.-Q.; Zhang, Y.-Y.; Pu, J.-Y.; Tang, M.-C.; Peng, C.; Tang, G.-L.* Catalysis of extracellular deamination by a FAD-linked oxidoreductase after prodrug maturation in the biosynthesis of saframycin A. Angew. Chem. Int. Ed. 2017, 56, 9116-9120.
10. Zhang, Z.; Gong, Y.-K.; Zhou, Q.; Hu, Y.; Ma, H.-M.; Chen, Y.-S.; Igarashi, Y.; Pan, L.*; Tang, G.-L.* Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade. Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 1554–1559.
11. He, H.-Y.; Yuan, H.; Tang, M.-C.; Tang, G.-L.* An unusual dehydratase acting on glycerate and a ketoreducatse stereoselectively reducing α-ketone in polyketide starter unit biosynthesis. Angew. Chem. Int. Ed. 2014, 53, 11315-11319.
12. He, H.-Y.; Tang, M.-C.; Zhang, F.; Tang, G.-L.* Cis-Double bond formation by thioesterase and transfer by ketosynthase in FR901464 biosynthesis. J. Am. Chem. Soc. 2014, 136, 4488-4491.
13. Xu, H.; Huang, W.; He, Q.-L.; Zhao, Z.-X.; Zhang, F.; Wang, R.; Kang, J.; Tang, G.-L.* Self-resistance to antitumor antibiotic: a DNA glycosylase triggers the base excision repair system in yatakemycin biosynthesis. Angew. Chem. Int. Ed. 2012, 51, 10532-10536.
14. Huang, W.; Xu, H.; Li, Y.; Zhang, F.; Chen, X.-Y.; He, Q.-L.; Igarashi, Y.; Tang, G.-L.* Characterization of yatakemycin gene cluster revealing a radical SAM-dependent MT and highlighting spirocyclopropane biosynthesis. J. Am. Chem. Soc. 2012, 134, 8831-8840.
15. Peng, C.; Pu, J.-Y.; Song, L.-Q.; Jian, X.-H.; Tang, M.-C.; Tang, G.-L.* Hijacking a hydroxyethyl unitfrom a central metabolic ketose into a nonribosomal peptide assembly line. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 8540-8545.
16. Zhang, F.; He, H.-Y.; Tang, M.-C.; Zhou, Q.; Tang, G.-L.* Cloning and elucidation of the FR901464 gene cluster revealing a complex AT-less PKS using glycerate as starter units. J. Am. Chem. Soc. 2011, 133, 2452-2462.
唐功利
上海市
研究领域：
天然气化工,新材料,石油炼制,石油化工,精细化工,生物医药
研究方向：
1) 天然产物生物合成研究：以微生物来源的结构新奇、活性显著的复杂天然产物为目标分子，从基因和蛋白水平揭示自然界神奇的生物化学过程，理解其中蕴涵的新型酶催化反应和生理拮抗机制；在此基础上一方面通过化学-生物相结合的策略来创造“非天然”天然产物，另一方面通过生物合成与生物信息相关联的方法激活沉默基因簇，进而发现新的天然产物。
2) 复杂天然产物类药物的高效制备：以生物合成途径为基础，采用微生物代谢工程或合成生物学的方法和策略致力于提高目标化合物的产量，改变发酵产物的组份及产生新化合物；进而通过与化学半合成或生物催化相结合发展高效的制备路线。
3) 抗肿瘤天然产物的化学生物学研究：利用优化的噬菌体展示克隆或与生物合成相关联的策略筛选、发现一些高活性天然产物的生物靶分子，进而研究其生物活性的机理。
所在单位：
中国科学院上海有机化学研究所
