论文著作：
1.Liu, D.; Liu, Y.; Duan, H.-Z.; Chen, X.; Wang, Y.; Wang, T.; Yu, Q.;Chen, Y.-X.*; Lu, Y.*, Customized synthesis of phosphoprotein bearing phosphoserine or its nonhydrolyzable analog.Synthetic and Systems Biotechnology2023,8(1), 69-78.
2.Duan, H.-Z.; Hu, C.; Li, Y.-L.; Wang, S.-H.; Xia, Y.; Liu, X.*; Wang, J.*;Chen, Y.-X.*, Genetically Encoded Phosphine Ligand for Metalloprotein Design.Journal of the American Chemical Society2022,14(50), 22831-22837.
3.Chang, R.; Chen, J.-L.; Zhang, G.-Y.; Li, Y.; Duan, H.-Z.; Luo, S.-Z.;Chen, Y.-X.*, Intrinsically Disordered Protein Condensate-Modified Surface for Mitigation of Biofouling and Foreign Body Response.Journal of the American Chemical Society2022,144(27), 12147-12157.
4.Chang, R.; Liu, Y.-J.; Zhang, Y.-L.; Zhang, S.-Y.; Han, B.-B.; Chen, F.*;Chen, Y.-X.*, Phosphorylated and Phosphonated Low-Complexity Protein Segments for Biomimetic Mineralization and Repair of Tooth Enamel.Advanced Science2022,9(6), 2103829.
5.Wu, J.-J.; Chen, F.-Y.; Han, B.-B.; Zhang, H.-Q.; Zhao, L.; Zhang, Z.-R.; Li, J.-J.; Zhang, B.-D.; Zhang, Y.-N.; Yue, Y.-X.; Hu, H.-G.; Li, W.-H.; Zhang, B.*;Chen, Y.-X.*; Guo, D.-S.*; Li, Y.-M.*, CASTING: A Potent Supramolecular Strategy to Cytosolically Deliver STING Agonist for Cancer Immunotherapy and SARS-CoV-2 Vaccination.CCS Chemistry2022, DOI: 10.31635/ccschem.022.202201859.
6.Li, Y.; Chang, R.;Chen, Y.-X.*, Recent Advances in Post-polymerization Modifications on Polypeptides: Synthesis and Applications.Chemistry-an Asian Journal2022,17(14), e202200318.
7.Hu, J.; Sun, X.-M.; Su, J.-Y.; Zhao, Y.-F.;Chen, Y.-X.*, Different phosphorylation and farnesylation patterns tune Rnd3-14-3-3 interaction in distinct mechanisms.Chemical Science2021,12(12), 4432-4442.
8.Zhu, P.-C.;Chen, Y.-X.*, Facile Synthesis of Boc-Protected Selenocystine and its Compatibility with Late-Stage Farnesylation at Cysteine Site.Protein and Peptide Letters2021,28(6), 603-611.
9.Li, F.-Y.; Zhang, Z.-F.; Voss, S.; Wu, Y.-W.; Zhao, Y.-F.; Li, Y.-M.;Chen, Y.-X.*, Inhibition of K-Ras4B-plasma membrane association with a membrane microdomain-targeting peptide.Chemical Science2020,11(3), 826-832.
10.Duan, H.-Z.; Nie, Z.-K.; Li, Y.;Chen, Y.-X.*, Unremitting progresses for phosphoprotein synthesis.Current Opinion in Chemical Biology2020,58, 96-111.
11.Hackenberger, C. P. R.*; Dawson, P. E.*;Chen, Y.-X.*; Hojo, H.*, Modern Peptide and Protein Chemistry: Reaching New Heights.Journal of Organic Chemistry2020,85(3), 1328-1330.
12.Han, B.-B.; Pan, Y.-C.; Li, Y.-M.; Guo, D.-S.*;Chen, Y.-X.*, A host-guest ATP responsive strategy for intracellular delivery of phosphopeptides.Chemical Communications2020,56(41), 5512-5515.
13.Zhang, Y.-L.; Chang, R.; Duan, H.-Z.;Chen, Y.-X.*, Metal ion and light sequentially induced sol-gel-sol transition of a responsive peptide-hydrogel.Soft Matter2020,16(33), 7652-7658.
14.Duan, H.-Z.; Chen, H.-X.; Yu, Q.; Hu, J.; Li, Y.-M.;Chen, Y.-X.*, Stereoselective synthesis of a phosphonate pThr mimetic via palladium-catalyzed gamma-C(sp(3))-H activation for peptide preparation.Organic & Biomolecular Chemistry2019,17(8), 2099-2102.
15.Gao, N.; Huang, Y.-P.; Chu, T.-T.; Li, Q.-Q.; Zhou, B.;Chen, Y.-X.*; Zhao, Y.-F.; Li, Y.-M.*, TDP-43 specific reduction induced by Di-hydrophobic tags conjugated peptides.Bioorganic Chemistry2019,84, 254-259.
16.Chen, H.-X.; Kang, J.; Chang, R.; Zhang, Y.-L.; Duan, H.-Z.; Li, Y.-M.;Chen, Y.-X.*, Synthesis of alpha,alpha-Difluorinated Phosphonate pSer/pThr Mimetics via Rhodium-Catalyzed Asymmetric Hydrogenation of beta-Difluorophosphonomethyl alpha-(Acylamino)acrylates.Organic Letters2018,20(11), 3278-3281.
17.Huang, S.-Q.; Han, B.-B.; Li, Y.-M.;Chen, Y.-X.*, A site-specific branching poly-glutamate tag mediates intracellular protein delivery by cationic lipids.Biochemical and Biophysical Research Communications2018,503(2), 671-676.
18.Hu, J.; Zhu, P.; Li, Y.;Chen, Y.-X.*, Synthesis of Ras proteins and their application in biofunctional studies.Chinese Chemical Letters2018,29(7), 1043-1050.
19.Yu, Q.; Sun, J.; Huang, S.; Chang, H.; Bai, Q.;Chen, Y.-X.*; Liang, D.*, Inward Budding and Endocytosis of Membranes Regulated by de Novo Designed Peptides.Langmuir2018,34(21), 6183-6193.
20.Zhang, S.-Y.; Sperlich, B.; Li, F.-Y.; Al-Ayoubi, S.; Chen, H.-X.; Zhao, Y.-F.; Li, Y.-M.; Weise, K.; Winter, R.*;Chen, Y.-X.*, Phosphorylation Weakens but Does Not Inhibit Membrane Binding and Clustering of K-Ras4B.ACS Chemical Biology2017,12(6), 1703-1710.
21.Kang, J.; Chen, H.-X.; Huang, S.-Q.; Zhang, Y.-L.; Li, F.-Y.; Li, Y.-M.;Chen, Y.-X.*, Facile synthesis of Fmoc-protected phosphonate pSer mimetic and its application in assembling a substrate peptide of 14-3-3 zeta.Tetrahedron Letters2017,58(26), 2551-2553.
22.Gao, N.; Chu, T. T.; Li, Q. Q.; Lim, Y. J.; Qiu, T.; Ma, M. R.; Hu, Z. W.; Yang, X. F.;Chen, Y.-X.*; Zhao, Y. F.; Li, Y. M.*, Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau.RSC Advances2017,7(64), 40362-40366.
23.Shi, L.; Chen, H.; Zhang, S. Y.; Chu, T. T.; Zhao, Y. F.;Chen, Y.-X.*; Li, Y. M.*, Semi-synthesis of murine prion protein by native chemical ligation and chemical activation for preparation of polypeptide--thioester.Journal of Peptide Science2017,23(6), 438-444.
24.Chu, T.-T.; Gao, N.; Li, Q.-Q.; Chen, P.-G.; Yang, X.-F.;Chen, Y.-X.*; Zhao, Y.-F.; Li, Y.-M.*, Specific Knockdown of Endogenous Tau Protein by Peptide-Directed Ubiquitin-Proteasome Degradation.Cell Chemical Biology2016,23(4), 453-461.
25.Li, L.; Zhang, S.-Y.; Li, Y.-M.;Chen, Y.-X.*, Dual-labeling of ubiquitin proteins by chemoselective reactions for sensing UCH-L3.Molecular Biosystems2016,12(6), 1764-1767.
26.He, Y.-H.; Li, Y.-M.;Chen, Y.-X.*, Phosphorylation regulates proteolytic efficiency of TEV protease detected by a 5(6)-carboxyfluorescein-pyrene based fluorescent sensor.Talanta2016,150, 340-345.
陈永湘
北京市
研究领域：
生物医药
研究方向：
蛋白质和多肽化学生物学，修饰蛋白质的合成及生物医学功能研究
所在单位：
清华大学
