精细化工

不对称合成、化学生物学、光催化的有机反应

Copper;Cross-coupling;Ullmann Reaction;Peptide Sequencing;Copper-catalyzed;Synthetic Methods;Homogeneous Catalysis;C-H Activation;Electrospray Ionization Mass Spectrometry

Copper;Synthetic Methods;Oxidative Coupling;Synthetic Method;Cross-coupling;Homogeneous Catalysis;Nickel-catalyzed;Nitrogen Heterocycles;Arylation;Visible Light Photoredox Catalysis

(1) 建立了多种含磷化合物合成新方法；
(2) 建立了新颖、高效的铜催化剂体系，实现了芳环上官能团(氨基、羟基、硝基、磺酰基、羧基等)的转化；(3) 建立了铜催化C-H键功能化构建C-N、C-O、C-C键的新方法；
(4) 建立了铜催化合成喹唑啉、喹唑啉酮、苯并咪唑、苯并噻嗪、咪唑啉酮、吲哚、异喹啉酮等多种杂环化合物的新方法；
(5) 研发出了多种具有新颖、高效的轴手性配体，高对映选择性的用于不对称合成中；
(6) 建立了多种可见光催化有机合成的新方法；
(7) 研发出了细胞膜通透性较好、活性较高的磷杂香豆素类和醛类蛋白酪氨酸磷酸酯酶抑制剂；
(8) 发展了核苷多聚磷酸酯与不保护的氨基酸、肽、氨基核苷和氨基糖反应构建了核苷－氨基酸、核苷－肽、核苷－糖缀合物等化合物的新方法；
(9) 建立了生物大分子的生物正交连接与剪切新方法。

1.Youshan Li, Zhenbang Lou, Hongyun Li, Haijun Yang, Yufen Zhao, Hua Fu*, Bioorthogonalligation and cleavage by reactions of chloroquinoxalines withortho-dithiophenols.Angew.Chem.Int.Ed.2020,59(9), 3671-3677.
2.Youshan Li, Hua Fu*, Bioorthogonal ligations and cleavages in chemical biology,ChemistryOpen2020,9(8), 835-853.
3.Ningning Man, Zhenbang Lou, Yuming Li, Haijun Yang, Yufen Zhao, Hua Fu*, Organocatalyticatroposelective construction of axially chiralN-aryl benzimidazoles involving carbon-carbon bond cleavage,Org.Lett.2020,22(16), 6382-6387.
4.Xi Yuan, Xudong Wu, Fei Peng, Haijun Yang, Changjin Zhu, Hua Fu*, Organocatalytic asymmetric synthesis of arylindolyl indolin-3-ones with both axial andcentral chirality,Chem.Commun.2020,56(83), 12648-12651.
5.Xianjin Zhu, Can Liu, Yong Liu, Haijun Yang, Hua Fu*, A sodium trifluoromethanesulfinate-mediated photocatalytic strategy for aerobic oxidation of alcohols,Chem.Commun.2020,56(82), 12443-12446.
6.Xianjin Zhu, Yong Liu, Can Liu, Haijun Yang, Hua Fu*, Light and oxygen-enabled sodium trifluoromethanesulfinate-mediated selective oxidation of C-H bonds,Green Chem.2020,22(13), 4357-4363.
7.Hua Tian, Fei Peng, Pengxiang Zhang, Haijun Yang,Hua Fu*, Highlyenantioselective iridium-catalyzed cascade double allylation strategy: synthesis of pyrrolidinoindolines with an all-carbon quaternary stereocenter,Org.Lett.2019,21(20), 8501-8505.
8.Xudong Wu, Xi Yuan, Haijun Yang, Hua Fu*, Chiralphosphoric acid catalyzed asymmetric addition of 2-(vinyloxy)ethanol to imines and applications of the products,Org.Lett.2019,21(13), 5335-5340.
9.Xi Yuan, Xudong Wu, Pengxiang Zhang, Fei Peng, Can Liu, Haijun Yang, Changjin Zhu, Hua Fu*, Axiallychiral cyclic phosphoric acid enabled enantioselective sequential additions,Org.Lett.2019,21(8), 2498-2503.
10.Yongzhen Han, Yunhe Jin, Min Jiang, Haijun Yang, Hua Fu*, Photocatalyst-free visible-light photoredox dearomatization of phenol derivativescontaining ketoximes: Aneasy access to spiropyrrolines.Org.Lett.2019,21(6), 1799-1803.
11.Min Jiang, Haijun Yang, Quentin Lefebvre, Jihu Su, Hua Fu*, “Olefination of alkyl halides with aldehydes by merging visible-light photoredox catalysis and organophosphorus chemistry”iScience2018,6, 102-113.
12.Can Liu, Xianjin Zhu, Pengxiang Zhang, Haijun Yang, Changjin Zhu, Hua Fu*, “Axially chiral cyclic diphosphine ligand-enabled palladium-catalyzed intramolecular asymmetric hydroarylation”iScience2018,10, 11-22.
13.Yunhe Jin, Lunyu Ou, Haijun Yang,Hua Fu*, “Visible-light-mediated aerobic oxidation ofN-alkylpyridinium salts under organic photocatalysis”,J. Am. Chem. Soc.2017,139(40), 14237-14243.
14.Min Jiang,Haifang Li, Haijun Yang,Hua Fu*,“Room-temperature arylation of thiols: breakthrough with aryl chlorides”,Angew. Chem. Int. Ed.2017,56(3),874-879.
15.Jingjing Li, Quentin Lefebvre,Haijun Yang,Yufen Zhao,Hua Fu*, “Visible light photocatalytic decarboxylative monofluoroalkenylation of α-amino acids withgem-difluoroalkenes”,Chem. Commun.2017,53(74), 10299-10302.
16. Fei Peng, Hua Tian, Pengxiang Zhang, Can Liu, Xudong Wu, Xi Yuan, Haijun Yang, Hua Fu*,“Iridium-catalyzed enantioselective synthesis of dihydroimidazoquinazolinones by elaborate tuning of chiral cyclic ligands”,Org. Lett.2017,19(23), 6376-6379.
17. Hua Tian, Pengxiang Zhang, Fei Peng, Haijun Yang, Hua Fu*, “Chiral cyclic ligand-enabled iridium-catalyzed asymmetric arylation of unactivated racemic allylic alcohols with anilines”,Org. Lett.2017,19(14), 3775-3778.
18. Jinyan Yang, Min Jiang, Yunhe Jin, Haijun Yang, Hua Fu*, “Visible-light photoredox difluoromethylation of phenols and thiophenols with commercially available difluorobromoacetic acid”,Org. Lett.2017,19(10), 2758-2761.
19.Hao Zhang, Pengxiang Zhang,Min Jiang, Haijun Yang, Hua Fu*, “Merging photoredox with copper catalysis: decarboxylative alkynylation of α-amino acid derivatives”,Org. Lett.2017,19(5), 1016-1019.
20. Jingjing Li, Pengxiang Zhang, Min Jiang, Haijun Yang, Yufen Zhao, Hua Fu*, “Visible light as a sole requirement for intramolecular C(sp3)-Himination”,Org. Lett.2017,19(8), 1994-1997.
21.Yunhe Jin, Min Jiang, Hui Wang, Hua Fu*, “Installing amino acids and peptides onN-heterocycles under visible-light assistance”,Sci. Rep.2016,6,20068.
22.Hua Tian, Haijun Yang, Changjin Zhu, Hua Fu*, “Transition metal-free intramolecular regioselective couplings of aliphatic and aromatic C-H bonds”,Sci. Rep.2016,6,19931.
23.MinJiang, Yunhe Jin, Haijun Yang, Hua Fu*, “Visible-light photoredox synthesis of unnatural chiral α-amino acids”,Sci. Rep.2016,6,26161.
24.Jingjing Li, Hua Tian, Min Jiang, Haijun Yang, Yufen Zhao, Hua Fu*,“Consecutive visible-light photoredox decarboxylative couplings of adipic acid active esters with alkynyl sulfones leading to cyclic compounds”,Chem. Commun.2016,52(57), 8862-8864.
25.Chang Gao, Jingjing Li, Jipan Yu, Haijun Yang, Hua Fu*,“Visible-light photoredox synthesis of internal alkynes containing quaternary carbons”,Chem. Commun.2016,52(45), 7292-7294.
26.YunheJin, Haijun Yang, Hua Fu*, “AnN-(acetoxy)phthalimide motif as a visible-light pro-photosensitizer in photoredox decarboxylative arylthiation”,Chem. Commun.2016,52(87), 12909-12912.
27.Pengxiang Zhang, Jipan Yu, Fei Peng, Xudong Wu, Jiyang Jie, Can Liu, Hua Tian, Haijun Yang,Hua Fu*,“Developmentof axially chiral cyclo-biaryldiol ligands with adjustable dihedral angles”,Chem. Eur. J.2016,22(48), 17477-17484.
28.HaoZhang, Haifang Li, Haijun Yang, Hua Fu*,“Iron-catalyzed diastereoselective synthesis of unnatural chiral amino acid derivatives”,Org. Lett.2016,18(14), 3362-3365.
29.Min Jiang, Haijun Yang, Hua Fu*,“Visible-light photoredox synthesis of chiral α-selenoamino acids”,Org. Lett.2016,18(9), 1968-1971.
30.Min Jiang, Haijun Yang, Hua Fu*,“Visible-light photoredox borylation of aryl halides and subsequent aerobic oxidative hydroxylation”,Org. Lett.2016,18(20), 5248-5251.
31.Yunhe Jin, Haijun Yang, Hua Fu*, “Thiophenol-catalyzed visible-light photoredox decarboxylative couplings of N-(acetoxy)phthalimides”,Org. Lett.2016,18(24), 6400-6403.
32.Hua Tian,Jipan Yu, Haijun Yang, Changjin Zhu,Hua Fu*,“Catalyst-free isothiocyanatoalkylthiationof styrenes with (alkylthio)pyrrolidine-2,5-diones andtrimethylsilyl isothiocyanate”,Adv.Synth.Catal.2016,358(11), 1794-1800.
33.Jipan Yu,Min Jiang, ZhixuanSong, Tiancheng He,Haijun Yang,Hua Fu*,“Iron-catalyzed azidoalkylthiation of alkenes with trimethylsilyl azide and 1-(alkylthio)pyrrolidine-2,5-diones”,Adv.Synth.Catal.2016,358(17),2806-2810.
34.Hui Wang, Yuyuan Wang, Haijun Yang, Chunyan Tan, Yuyang Jiang, Yufen Zhao, Hua Fu*, “Rhodium-catalyzed desulfination of sodium arenesulfinates and oxidative annulation with alkynes”,Adv.Synth.Catal.2015,357(2-3), 489-499.
35.Hua Tian, Haijun Yang, Changjin Zhu, Hua Fu*, “Arylthiolation ofarylamine derivatives with (arylthio)-pyrrolidine-2,5-diones”,Adv.Synth.Catal.2015,357(2-3), 481-488.
36.Zhenbang Lou, Xudong Wu, Haijun Yang, Changjin Zhu, Hua Fu*, “Copper-catalyzed domino synthesis of benzo[4,5]imidazo[1,2-a]pyrimidin-4(10H)-ones using cyanamide as a building block”,Adv.Synth.Catal.2015,357(18), 3961-3968.
37.Hua Tian, Changjin Zhu, Haijun Yang, Hua Fu*, “Iron or boron-catalyzed C-H arylthiation of substituted phenols at room temperature”,Chem. Commun.2014,50(64), 8875-8877.
38.Jie Zhao, Zhiqiang Niu, Hua Fu*,Yadong Li*,“Ligand-free hydroborationof alkynes catalyzed by heterogeneous copper powder with high efficiency”,Chem. Commun.2014,50(16), 2058-2060.
39.Liangliang Shi,Xiaobo Yang,Yuyuan Wang, Haijun Yang,Hua Fu*,“Metal-free trifluoromethylation and arylation of alkenes: domino synthesis of oxindole derivatives”,Adv. Synth. Catal.2014,356(5), 1021-1028.
40.Jipan Yu, Haijun Yang,Hua Fu*,“Metal-free trifluoromethylation ofN-allylamides with sodium trifluoromethanesulfinate: synthesis ofCF3-containing oxazolines”,Adv. Synth. Catal.2014,356(17),3669-3675.
41.Jipan Yu, Yunhe Jin, Hao Zhang, Xiaobo Yang, Hua Fu*,“Copper-catalyzed aerobic oxidative C-Hfunctionalization of substituted pyridines: synthesis of imidazopyridine derivatives”,Chem. Eur. J.2013,19(49), 16804-16808.
42.Jipan Yu,HaijunYang,YuyangJiang, Hua Fu*,“Copper-catalyzed aerobic oxidative C-H and C-Cfunctionalization of 1-(2-(arylamino)aryl)ethanones leading to acridone derivatives”,Chem. Eur. J.2013,19(13), 4271-4277.
43.FengWang, HaijunYang,Hua Fu*, Zhichao Pei*,“Efficient copper-catalyzed Michael addition of acrylic derivatives with primary alcohols in the presence of base”,Chem. Commun.2013,49(5),517-519.
44.Liting Niu,Haijun Yang,Yuyang Jiang, Hua Fu*,“Efficient synthesis of dibenzoxaborininols from diaryl ethers and their application to dibenzofuran synthesis”,Adv. Synth. Catal.2013,355(18),3625-3632.
45.Yuyuan Wang, Ruji Wang, Yuyang Jiang, Chunyan Tan*, Hua Fu*,“Copper-catalyzed domino synthesis of 4-oxopyrimido[1,2-a]indole derivatives”,Adv. Synth. Catal.2013,355(14-15), 2928-2935.
46.Tao Liu,Haijun Yang,Yuyang Jiang, Hua Fu*,“Copper-catalyzed selectively oxidative acylation of secondary anilines with ethyl glyoxalate: domino synthesis of indoline-2,3-diones”,Adv. Synth. Catal.2013,355(6), 1169-1176.
47.Liangliang Shi,Haijun Yang,Yuyang Jiang, Hua Fu*,“Copper-catalyzed C-arylation and denitrogenation of tetrazoles: domino synthesis of 1,3-diaminoisoquinoline derivatives”,Adv. Synth. Catal.2013,355(6), 1177-1184.
48.Juyou Lu,Hao Zhang, Xiaowu Chen,Hongxia Liu, Yuyang Jiang,Hua Fu*,“Palladium-catalyzed synthesis of aromatic ketones and isoindolobenzimidazoles via selective aromatic C-Hbond acylation”,Adv. Synth. Catal.2013,355(2-3),529-536.
49.Juyou Lu, Haijun Yang, Yunhe Jin, Yuyang Jiang,Hua Fu*,“Easy conjugations between molecules via copper-catalyzedreactions ofortho-aromatic diamines withketones”,Green Chem.2013,15(11), 3184-3187.
50.Ruilong Xie, Yun Ling*, Hua Fu*,“Copper-catalyzed synthesisof benzocarbazoles via α-C-arylation of ketones”,Chem. Commun.2012,48(100), 12210-12212.
51.HaoXu,Hua Fu*,“Copper-catalyzed one-pot synthesis of imidazo/benzoimidazoquinazolinones by sequential Ullmann-type coupling and intramolecular C-Hamidation”,Chem. Eur. J.2012,18(4), 1180-1186.
52.Xiaoqiang Wang, Yunhe Jin, Yufen Zhao, Lin Zhu,Hua Fu*, “Copper-catalyzed aerobic oxidative intramolecularC-Hamination leading to imidazobenzimidazole derivatives”,Org. Lett.2012,14(2),452-455.
53.Liting Niu, Haijun Yang, Ruji Wang,Hua Fu*,“Metal-freeorthoC-Hborylation of 2-phenoxypyridines under mild conditions”,Org. Lett.2012,14(10),2618-2621.
54.Jie Zhao, Yufen Zhao, Hua Fu*,“K2CO3-catalyzed synthesis of chromones and 4-quinolones through the cleavage of aromatic C-O Bonds”,Org. Lett.2012,14(11),2710-2713.
55.Daoshan Yang, Yuyuan Wang, Haijun Yang, Tao Liu, Hua Fu*, “Copper-catalyzed domino synthesis of benzimidazo[2,1-b]quin- azolin-12(6H)-onesusing cyanamide as a building block”,Adv. Synth. Catal.2012,354(2-3), 477-482.
56.Liting Niu, Haijun Yang, Daoshan Yang, Hua Fu*,“Functionalizations ofaryl C-Hbonds in 2-arylpyridines via sequential borylation and copper catalysis”,Adv. Synth. Catal.2012,354(11-12), 2211-2217.
57.Tao Liu, Congyu Zhu, Haijun Yang, Hua Fu*, “Copper-catalyzed domino synthesis of isoquinolino[2,3-a]quinazolinones”,Adv. Synth. Catal.2012,354(8), 1579-1584.
58.JieZhao, YufenZhao,Hua Fu*, “Transition-metal-free intramolecular Ullmann-type O-arylation: synthesis of chromone derivatives”,Angew. Chem. Int. Ed.2011,50(16),3769-3773.
59.DaoshanYang, Haijun Yang,Hua Fu*,“Copper-catalyzed aerobic oxidative synthesis of aromatic carboxylic acids”Chem. Commun.2011,47(8),2348-2350.
60.ShanXu, Juyou Lu,Hua Fu*,“Copper-catalyzed cascade synthesis of benzimidazoquinazoline derivatives under mild condition”,Chem. Commun.2011,47(19),5596-5598.
61.RuilongXie,Hua Fu*,YunLing*, “Copper-catalyzed N-arylation of amines with part-per-million catalyst loadings under air at room temperature”,Chem. Commun.2011,47(31),8976-8978.
62.HaijunYang, Yong Li, Min Jiang, Junmei Wang,Hua Fu*,“General copper-catalyzed transformations of functional groups from arylboronic acids in water”,Chem. Eur. J.2011,17(20), 5652-5660.
63.TaoLiu, Ruiji Wang,HaijunYang,Hua Fu*,“Efficientcopper-catalyzed synthesis of poly-N-heterocycles containing amino acid residues”,Chem. Eur. J.2011,17(24), 6765-6771.
64.WeiXu, Yibao Jin, Hongxia Liu,Yuyang Jiang,Hua Fu*,“Copper-catalyzed domino synthesis of quinazolinones via Ullmann-type coupling and aerobic oxidative C-Hamidation”,Org. Lett.2011,13(6),1274-1277.
65.Juyou Lu, Yibao Jin, Hongxia Liu,Yuyang Jiang,Hua Fu*,“Copper-catalyzed aerobic oxidative intramolecular alkene C-Hamination leading toN-heterocycles”,Org. Lett.2011,13(14),3694-3697.
66.JuyouLu,Hua Fu*,“Copper-catalyzed cascade synthesis of alkyl 6-aminobenzimidazo[2,1-a]isoquinoline-5-carboxylates”,J. Org. Chem.2011,76(11),4600-4605.
67.Wei Xu,Hua Fu*,“Aminoacids as the nitrogen-containing motifs in copper-catalyzed domino synthesisofN-heterocycles”,J. Org. Chem.2011,76(10),3846-3852.
68.HaoXu,ShangfuLi,HongxiaLiu,Hua Fu*,YuyangJiang*,“Simpleand efficient copper-catalyzed cascade synthesis of naphthols containing multifunctional groups under mild conditions”,Chem. Commun.2010,46(40),7617-7619.
69.JuyouLu,XiaoyuGong,HaijunYang,Hua Fu*,“Concisecopper-catalyzed one-pot tandem synthesis of benzimidazo[1,2-b]isoquinolin-11-one derivatives”,Chem. Commun.2010,46(23),4172-4174.
70.DaoshanYang, Hua Fu*,“Asimple and practical copper-catalyzed approach to substituted phenols from aryl halides using water as the solvent”,Chem.Eur.J.2010,16(8),2366-2370.
71.XiaoyuGong, Haijun Yang, Hongxia Liu,Yuyang Jiang,Yufen Zhao,Hua Fu*,“Simpleandefficient copper-catalyzed approach to 2,4-disubstituted imidazolones”,Org. Lett.2010,12(14),3128-3131.
72.Xiaobo Yang, Hua Fu*,RenzhongQiao*,Yuyang Jiang,Yufen Zhao,“A Simple copper-catalyzed cascade synthesis of 2-amino-1hindole-3-carboxylate derivatives”,Adv. Synth. Catal.2010,352(6),1033-1038.
73.HonghuaRao, Hua Fu*,Yuyang Jiang,Yufen Zhao,“Highly efficient copper-catalyzed synthesis of internal alkynes via aerobic oxidative arylation of terminal alkynes”,Adv. Synth. Catal.2010,352(2-3), 458-462.
74.XufengLi,DaoshanYang,Yuyang Jiang,Hua Fu*,“Efficient copper-catalyzedN-arylations of nitrogen-containing heterocycles and aliphatic amines in water”,Green Chem.2010,12(6), 1097-1105.
75.ChenWang,ShangfuLi,HongxiaLiu,YuyangJiang,Hua Fu*,“Copper-catalyzed synthesis of quinazoline derivatives viaUllmann-type coupling and aerobic oxidation”,J. Org. Chem.2010,75(22),7936-7938.
76.HaiboZhao,Hua Fu*,Renzhong Qiao*,“Copper-catalyzed direct amination ofortho-functionalized haloarenes with sodium azide as the amino source”,J. Org. Chem.2010,75(10),3311-3316.
77.HonghuaRao,Hua Fu*, Yuyang Jiang,Yufen Zhao,"Easy Copper-catalyzed synthesis of primary aromatic amines by coupling aromatic boronic acids with aqueous ammonia at room temperature",Angew. Chem. Int. Ed.2009,48(6), 1114-1116.
78.XiaoweiLiu,Hua Fu*, Yuyang Jiang,Yufen Zhao,“Asimple and highly efficient approach to quinazolinones under mild copper-catalyzed conditions”,Angew. Chem. Int. Ed.2009,48(2), 348-351.
79.Feng Wang,Hongxia Liu,Hua Fu*,Yuyang Jiang*,Yufen Zhao,“Anefficient one-pot copper-catalyzed approach to isoquinolin-1(2H)-onederivatives”,Org. Lett.2009,11(11), 2469-2472.
80.Liang Zeng, Hua Fu*,RenzhongQiao*,Yuyang Jiang,Yufen Zhao,“Efficient copper-catalyzed synthesis ofN-alkylanthranilic acids via anortho-substituent effect of the carboxyl group of 2-halobenzoic acids at room temperature”,Adv. Synth. Catal.2009,351(10), 1671-1676.
81.FengWang, Hongxia Liu,Hua Fu*,Yuyang Jiang*,Yufen Zhao,“Highlyefficient iron(II)chloride/N-bromosuccinimide-mediated synthesis of imides and acylsulfonamides”,Adv. Synth. Catal.2009,351(1-2),246-252.
82.Daoshan Yang,Hongxia Liu, HaijunYang, Hua Fu*,Liming Hu*, Yuyang Jiang,Yufen Zhao,“Copper-catalyzed synthesis of 1,2,4-benzothiadiazine 1,1-dioxide derivatives by coupling of 2-halobenzenesulfonamides with amidines”,Adv. Synth. Catal.2009,351(11-12), 1999-2004.
83.Daoshan Yang, Hua Fu*,Hu Liming, Yuyang Jiang,Yufen Zhao,“Environmentallyfriendly iron-catalyzed cascade synthesis of 1,2,4-benzothiadiazine 1,1-dioxide and quinazolinone derivatives”,J. Comb. Chem.2009,11(4),653-657.
84.ChengHuang,Hua Fu*,Yuyang Jiang*,Yufen Zhao,“Highlyefficient copper-catalyzed cascade synthesis of quinazoline ans quinazolinone derivatives”,Chem. Commun.2008,(47),6333-6335.
85.LongWang, Hua Fu*,Yuyang Jiang,Yufen Zhao,“Highlyefficient copper-catalyzed amidation of aldehydes via C-Hactivation”,Chem.Eur.J.2008,14(34),10722-10726.
86.Zhe Wang, YongmingZhang,Hua Fu*,Yuyang Jiang,Yufen Zhao,“Efficientintermolecular iron-catalyzed amidation of C-Hbonds in the presence ofN-bromosuccinimide”,Org. Lett.2008,10(9),1863-1866.
87.FengWang,Hua Fu*,Yuyang Jiang,Yufen Zhao,“Copper-catalyzed cycloaddition of sulfonyl azides with alkynes to synthesizeN-sulfonyltriazoles ‘on water’ at room temperature”,Adv. Synth. Catal.2008,350(11-12), 1830-1834.
88.FengWang,Hua Fu*,Yuyang Jiang,Yufen Zhao,“Quick andhighly efficient copper-catalyzed cycloaddition of aliphatic and aryl azides with terminal alkynes ‘on water’”,Green Chem.2008,10(4), 452-456.
89.DaoshanYang,Hua Fu*,LimingHu*,Yuyang Jiang,Yufen Zhao,“Copper-catalyzed synthesis of benzimidazoles via cascade reactions of o-haloacetanilide derivatives with amidine hydrochlorides”,J. Org. Chem.2008,73(19),7841-7844.
90.XiaoweiLiu,YongmingZhang, LongWang,Hua Fu*,Yuyang Jiang,Yufen Zhao,“General andefficient copper-catalyzed amidation of saturatedC-Hbonds usingN-halosuccinimides as the oxidants”,J. Org. Chem.2008,73(16),6207-6212.
91.MingyuNiu, ZhenmingYin,Hua Fu*,Yuyang Jiang,Yufen Zhao,“Copper-catalyzed coupling of tertiary aliphatic amines with terminal alkynes to propargylamines via C-Hactivation”,J. Org. Chem.2008,73(10),3961-3963.
92.XiaotingGao,Hua Fu*,RenzhongQiao*,Yuyang Jiang,Yufen Zhao,“Copper-catalyzed synthesis of primary arylamines via cascade reactions of aryl halides with amidine hydrochlorides”,J. Org. Chem.2008,73(17),6864-6866.
93.MingyuNiu, Hua Fu*,Yuyang Jiang,Yufen Zhao,“Copper-catalyzed addition ofH-phosphine oxides to alkynes forming alkenylphosphine oxides”,Chem.Commun.2007,(3),272 – 274.
94.YongmingZhang,Hua Fu*,Yuyang Jiang,Yufen Zhao,“Copper-catalyzed amidation of sp3C-Hbonds adjacent to a nitrogen atom”,Org. Lett.2007,9(19),3813-3816.
95.Daoshan Jiang, Hua Fu*,Yuyang Jiang,Yufen Zhao,“CuBr/rac-BINOL-catalyzedN-arylations of aliphatic amines at room temperature”,J. Org. Chem.2007,72(2),672-674.
96.HonghuaRao, Yin Jin,Hua Fu*,Yuyang Jiang,Yufen Zhao,“Aversatile and efficient ligand for formation of copper-catalyzed C-N, C-O and P-Cbonds: pyrrolidine-2-phosphonic acid phenyl monoester”,Chem.Eur.J.2006,12(13),3636-3646.
97.Xun Guo, HonghuaRao, Yin Jin,Hua Fu*,Yuyang Jiang,Yufen Zhao,“An inexpensive and efficient copper catalyst forN-arylation of amines, amides and nitrogen-containing heterocycles”,Adv. Synth. Catal.2006,348(15),2197-2202.
98.ChengHuang, Xu Tang,Hua Fu*,Yuyang Jiang,Yufen Zhao,“Proline/pipecolinic acid-promoted copper-catalyzedP-arylation”,J. Org. Chem.2006,71(13),5020-5022.
99.JigangZhu, Hua Fu*,Yuyang Jiang,Yufen Zhao,“Ageneral and chemoselective synthesis of phosphoramidates through reaction of silylated nucleoside di- and triphosphates with silylated amines containing multifunctional groups”,J. Org. Chem.2006,71(21),1721-1724.
100.Xueshu Li,Dongwei Zhang,Hai Pang, Feng Shen, Hua Fu*,Yuyang Jiang,Yufen Zhao,“Synthesis of adiverse series of phosphacoumarins with biological activity”,Org. Lett.2005,7(22),4919-4922.
101.TingYang, Changxue Lin,Hua Fu*,Yuyang Jiang,Yufen Zhao,“Copper-catalyzed synthesis of medium- and large-sized nitrogen heterocycles viaN-arylation of phosphoramidates and carbamates”,Org. Lett.2005,7(21),4781-4784.
102.HonghuaRao,Hua Fu*,Yuyang Jiang,Yufen Zhao,“Copper-catalyzed arylation of amines using diphenyl pyrrolidine-2-phosphonate as the new ligand”,J. Org. Chem.2005,70(20),8107-8109.
103.JigangZhu, Bo Han, Hua Fu*,Yuyang Jiang,Yufen Zhao,“Novel synthesis of nucleoside 5'-phosphoramidates through reaction of nucleoside triphosphates with amines mediated by trimethylsilyl chloride”,J. Org. Chem.2005,70(17),6676-6679.
104.Huiwang Ai, Hua Fu*,Yufen Zhao,“Novel synthetic method of phosphonamidate peptides and its application in peptide sequencing via multistage mass spectrometry”,Chem.Commun.2003,(21),2724-2725.
105.Hua Fu*,Bo Han, Yufen Zhao,“Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride”,Chem.Commun.2003,(1),134-135.

1. 一种多取代轴手性联苯二酚化合物及其制备方法与应用
清华大学
付华; 竭继阳; 肖维新
公开日期: 2025-02-11 申请日期: 2022-09-19 公开号: CN116102406B

2. 含同位素氧原子的标记物及其制备方法和应用
清华大学
付华; 朱先进; 刘勇
公开日期: 2022-08-30 申请日期: 2021-02-25 公开号: CN114956933A

3. 一种高密度光反应箱及光催化设备
清华大学
付华; 朱先进
公开日期: 2020-12-04 申请日期: 2019-12-20 公开号: CN212068697U

4. 一种含亚磺酸、磺酸或其衍生物的需氧氧化体系及其光促氧化方法
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清华大学
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清华大学
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清华大学
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清华大学
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