论文著作：
XJ Cao, JH Zheng, RL Zhang, Y Sun,MP Zhao*, Live-cell imaging of human apurinic/apyrimidinic endonuclease 1 in the nucleus and nucleolus using a chaperone@DNA probe,Nucleic Acids Research, 2024, 52(8), e41.
W Chen,HQ Xu, SB Dai, JY Wang, ZY Yang, YW Jin, MB Zou, XJ Xiao*, TB Wu*, W Yan, B Zhang, ZM Lin,MP Zhao*, Detection of low-frequency mutations in clinical samples by increasing mutation abundance via the excision of wild-type sequences,Nature Biomedical Engineering, 2023, 7, 1602. (https://rdcu.be/dhUlL).
ZY Yang, W Chen, JY Wang, MH Shi, RL Zhang, SB Dai, TB Wu*,MP Zhao*, Programmable One-Pot Enzymatic Reaction for Direct Fluorescence Detection of Ultralow-Abundance Mutations in the DNA Duplex,Analytical Chemistry, 2021, 93, 7086.
JQ Zhai, MH Zhao, XJ Cao, MY Li*,MP Zhao*, Metal-ion-responsive bionanocomposite for selective and reversible enzyme inhibition, Journal of theAmerican Chemical Society, 2018, 140, 16925.
TB Wu, YF Yang, W Chen, JY Wang, ZY Yang, SL Wang, XJ Xiao, MY Li,MP Zhao*, Noncanonical substrate preference of lambda exonuclease for 5'-nonphosphate-ended dsDNA and a mismatch-induced acceleration effect on the enzymatic reaction,Nucleic Acids Research, 2018, 46, 3119.
TB Wu, W Chen, ZY Yang, HC Tan, JY Wang, XJ Xiao, MY Li,MP Zhao*, DNA terminal structure-mediated enzymatic reaction for ultra-sensitive discrimination of single nucleotide variations in circulating cell-free DNA,Nucleic Acids Research, 2018, 46(4), e24.
XJ Xiao, TB Wu, L Xu, W Chen,MP Zhao*, A branch-migration based fluorescent probe for straightforward, sensitive and specific discrimination of DNA mutations,Nucleic Acids Research, 2017, 45 (10): e90.
JQ Zhai, YB Liu, S Huang, SM Fang,MP Zhao*, A specific DNA-nanoprobe for optically tracking the activities of human apurinic/apyrimidinic endonuclease 1 in living cells,Nucleic Acids Research, 2017, 45(6), e45.
XJ Xiao, TB Wu, FD Gu,MP Zhao*, Generation of artificial sequence-specific nucleases via preassembled inert-template,Chemical Science, 2016, 7, 2051.
SM Fang, L Chen,MP Zhao*, Unimolecular chemically modified DNA fluorescent probe for one-step quantitative measurement of the activity of human apurinic/ apyrimidinic endonuclease 1 in biological samples,Analytical Chemistry, 2015, 87, 11952.
ZY Chen, L Xu, Y Liang,MP Zhao*, pH-Sensitive water-soluble nanospheric imprinted hydrogels prepared as horseradish peroxidase mimetic enzyme,Advanced Materials, 2010, 22, 1488.
C Song,MP Zhao*, Real-time monitoring of the activity and kinetics of T4 polynucleotide kinase by a singly labeled DNA-hairpin smart probe coupled with exonuclease cleavage,Analytical Chemistry, 2009, 81, 1383.
赵美萍
北京市
研究领域：
生物医药
研究方向：
核酸酶与核酸相互作用的分子机理研究；
活细胞的不同亚细胞区室内核酸修复蛋白的原位荧光成像和结构解析；
基因损伤、基因突变、多重微生物基因序列的超高灵敏检测；
多聚蛋白分子印迹识别材料的制备方法和应用。
所在单位：
北京大学
