新材料,石油炼制,石油化工,精细化工,生物医药

核酸适体;胶体金

DNA;Aptamer;Aptamers;Cell Imaging;Fluorescent Probes;Fluorescent Probe;G-quadruplexes;Cell-selex;G-quadruplex;Drug Delivery

1. Aptamers Evolved from Live Cells As Effective Molecular Probes for Cancer Study
Dihua Shangguan; Ying Li; Zhiwen Tang; Zehui Charles Cao; Hui William Chen; Prabodhika Mallikaratchy; Kwame Sefah; Chaoyong James Yang; Weihong Tan
Proceedings of the National Academy of Sciences, 2006

2. Development of DNA Aptamers Using Cell-SELEX
Kwame Sefah; Dihua Shangguan; Xiangling Xiong; Meghan B O'Donoghue; Weihong Tan
Nature Protocols, 2010

3. Aptamer-Conjugated Nanoparticles for Selective Collection and Detection of Cancer Cells
Joshua K. Herr; Joshua E. Smith; Colin D. Medley; Dihua Shangguan; Weihong Tan
ANALYTICAL CHEMISTRY, 2006

4. Selection of Aptamers for Molecular Recognition and Characterization of Cancer Cells
Zhiwen Tang; Dihua Shangguan; Kemin Wang; Hui Shi; Kwame Sefah; Prabodhika Mallikratchy; Hui William Chen; Ying Li; Weihong Tan
ANALYTICAL CHEMISTRY, 2007

5. Cell-Specific Aptamer Probes for Membrane Protein Elucidation in Cancer Cells
Dihua Shangguan; Zehui Cao; Ling Meng; Prabodhika Mallikaratchy; Kwame Sefah; Hui Wang; Ying Li; Weihong Tan
JOURNAL OF PROTEOME RESEARCH, 2008

6. Molecular Assembly of an Aptamer–Drug Conjugate for Targeted Drug Delivery to Tumor Cells
Yu-Fen Huang; Dihua Shangguan; Haipeng Liu; Joseph A. Phillips; Xiaoling Zhang; Yan Chen; Weihong Tan
CHEMBIOCHEM, 2009

7. Aptamer-conjugated Nanoparticles for the Collection and Detection of Multiple Cancer Cells.
Joshua E. Smith; Colin D. Medley; Zhiwen Tang; Dihua Shangguan; Charles Lofton; Weihong Tan
ANALYTICAL CHEMISTRY, 2007

8. Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells.
Dihua Shangguan; Ling Meng; Zehui Charles Cao; Zeyu Xiao; Xiaohong Fang; Ying Li; Diana Cardona; Rafal P. Witek; Chen Liu; Weihong Tan
Analytical chemistry, 2008

9. Aptamer Directly Evolved from Live Cells Recognizes Membrane Bound Immunoglobin Heavy Mu Chain in Burkitt's Lymphoma Cells.
Prabodhika Mallikaratchy; Zhiwen Tang; Sefah Kwame; Ling Meng; Dihua Shangguan; Weihong Tan
MOLECULAR & CELLULAR PROTEOMICS, 2007

10. Cell-specific Internalization Study of an Aptamer from Whole Cell Selection.
Zeyu Xiao; Dihua Shangguan; Zehui Cao; Xiaohong Fang; Weihong Tan
Chemistry - A European Journal, 2007

1. 识别c-MET的核酸适体及其应用
中国科学院化学研究所
上官棣华; 张祥茹; 刘祥军; 张楠; 盛景
公开日期: 2025-04-01 申请日期: 2024-12-25 公开号: CN119736303A

2. Pulsating pneumatic motor, has high pressure gas along air pipe for pulse expansion to push air pipe of wheel to move, so as to drive cantilever to rotate around central axis of output shaft to perform power output.
SHANGGUAN D; HAN H
公开日期: 2024-10-31 申请日期: 2024-07-12 公开号: US2024360763A1

3. 一种核酸适配体识别并结合PTPRF及其相关功能的应用研究
中国科学院化学研究所
上官棣华; 邴涛; 甄笑笑; 吕静
公开日期: 2024-07-09 申请日期: 2020-06-19 公开号: CN113817740B

4. Data monitoring and analysis method executed by server of operation and maintenance system, involves determining monitoring object associated with first object, and determining risk level corresponding to change command according to identification of first object and of monitoring object.
SHANGGUAN D; ZHANG J; ZENG W
公开日期: 2024-04-04 申请日期: 2023-06-20 公开号: WO2024066506A1

5. 一种靶向c-MET的双特异性核酸适体的构建及应用
中国科学院化学研究所
上官棣华; 张祥茹; 张楠; 邴涛; 刘祥军
公开日期: 2024-03-29 申请日期: 2024-02-02 公开号: CN117778399A

6. Method for enabling use of sensors and signal emitting devices in transfer molded electronics, involves removing portion of charge material and cover to expose sensor or emitter to environment.
YANG C; IYER V; GEIGER D; SHANGGUAN D
公开日期: 2024-02-01 申请日期: 2023-08-07 公开号: US2024040703A1

7. Torsion-proof supporting structure of steel column, has web element that is provided between crane beam and chord element, and is respectively connected with crane beam, steel column and chord portion.
YUAN X; SHANGGUAN D; HU J; LI B
公开日期: 2023-12-22 申请日期: 2023-05-22 公开号: CN220225705U

8. 识别并结合c-MET蛋白的核酸适体及其应用
中国科学院化学研究所
张楠; 上官棣华; 刘祥军; 隆振豪
公开日期: 2023-12-05 申请日期: 2022-05-25 公开号: CN117165593A

9. Strong magnetic auxiliary leakage repairing device for metal storage tank, has patch pressure plate that is located between two strong magnets which slide on two sides of supporting rod.
GAO Z; XIONG B; CAO S; WANG F; ZHOU J; SHANGGUAN D
公开日期: 2023-08-11 申请日期: 2023-04-17 公开号: CN219503080U

10. Simple water meter detecting device, has detecting tank whose water outlet is connected with water tank through water return pipe to form water circulation loop, where water meter head of detected water meter is inserted into water meter flange.
SHANGGUAN D; ZHANG G; FENG G; WANG W; ZHANG Q; ZHANG D
公开日期: 2023-08-11 申请日期: 2023-04-17 公开号: CN219511639U

11. 识别并结合细胞朊蛋白的核酸适体及其应用
中国科学院化学研究所
上官棣华; 盛景; 张楠; 刘祥军; 隆振豪
公开日期: 2023-05-16 申请日期: 2022-11-01 公开号: CN116121254A

12. 识别CD171的核酸适体及其应用
中国科学院化学研究所
上官棣华; 隆振豪; 刘祥军; 邴涛; 张楠
公开日期: 2023-04-25 申请日期: 2022-10-19 公开号: CN116004635A

13. Wing plate type anti-reverse structure with side cutter groove, has anti-twist wing plate that is fixed on drilling tool frame and occupies groove space, and side cutter groove that is formed on borehole wall by rotating.
GUO Z; SHANGGUAN D; QI L
公开日期: 2022-12-21 申请日期: 2022-09-13 公开号: ZA202210138A

14. 一种日志数据的处理方法以及装置
HUAWEI TECH CO LTD
CHEN PENGFEI; Weng Tianjun; Cui Jieqi; ShangGuan Dongdong; CHANG JIA
公开日期: 2022-12-13 申请日期: 2021-06-10 公开号: CN115470066A

15. Base pit steel pipe temporary protective embedding device, has pipe body whose surface is provided with grouting hole, where inner wall of clamping joint and grouting pipe are provided with spring.
HUANG W; LI X; CHEN R; GAO D; CAI Z; TANG S; LIU W; OU J; DENG H; ZHANG Y; SHANGGUAN D; ZHANG L; LV X; JIANG W; WU C
公开日期: 2022-10-28 申请日期: 2022-04-13 公开号: CN217679122U

16. 靶标为碱性磷酸酶异源二聚体的核酸适体及其衍生物和应用
中国科学院化学研究所
上官棣华; 邴涛; 李胜男; 刘祥军; 张楠
公开日期: 2022-09-16 申请日期: 2022-06-24 公开号: CN115058429A

17. 一种核酸适体识别并结合CD171及其相关功能的应用研究
中国科学院化学研究所
上官棣华; 王林林; 邴涛; 刘祥军; 张楠; 沈璐瑶
公开日期: 2022-09-13 申请日期: 2017-12-12 公开号: CN109913462B

18. 一种用于靶向治疗的光活性核酸适体偶联药物及其制备方法与用途
中国科学院化学研究所
上官棣华; 刘祥军; 刘静; 张楠
公开日期: 2022-05-06 申请日期: 2021-12-10 公开号: CN114436960A

19. Methods of creating exposed cavities in molded electronic devices
FLEX LTD
SHANGGUAN DONGKAI; GEIGER DAVID; IYER VENKAT; YANG CHENG
公开日期: 2022-04-12 申请日期: 2019-12-10 公开号: US11304302B2

20. Encapsulating flexible electronic device involves providing mold shell made from first encapsulation material and providing portion of flexible electronic device inside the mold shell.
SHANGGUAN D; UY W L; TAN J A; LIU W
公开日期: 2022-03-29 申请日期: 2020-02-18 公开号: US11289393B2

1. 识别核仁素的G-四链体探针的构建与识别机理研究
立项时间: 2014-2017 项目经费：800000

2. 核酸适体分子在分析化学中的应用研究
立项时间: 2008-2010 项目经费：280000

3. 模拟核酸适体分子探针的构建
立项时间: 2011-2013 项目经费：350000

4. 植物激素分子探针的构建及原位检测方法的研究
立项时间: 2008-2010 项目经费：500000

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