生物医药

细胞基元功能化改造，新型活性生物材料

1. Qi-Wen Chen, Ji-Yan Qiao, Xin-Hua Liu, Cheng Zhang and Xian-Zheng Zhang*. Customized materials-assisted microorganisms in tumor therapeutics. Chem. Soc. Rev. 2021, 50, 12576-12615.
2. Qi-Wen Chen and Xian-Zheng Zhang*. Living Biomaterials: Fabrication Strategies and Biomedical Applications. Acc. Mater. Res. 2024, In press.
3. Qi-Wen Chen#, Yun Zhang#, Peng Bao and Xian-Zheng Zhang*. Sialidase-Chimeric Bioengineered Bacteria for Tumor-Sialoglycan-Triggered Solid Tumor Therapy. Nano Lett. 2024, 24, 10362-10371.
4. Qi-Wen Chen#, Ji-Yan Qiao#, Meng-Wei Cao, Zi-Yi Han, Xuan Zeng and Xian-Zheng Zhang*. Spore germinator-loaded polysaccharide microspheres ameliorate colonic inflammation and tumorigenesis through remodeling gut microenvironment. Mater. Today 2023, 63, 32-49.
5. Qi-Wen Chen#, Jia-Wei Wang#, Xia-Nan Wang, Jin-Xuan Fan, Xin-Hua Liu, Bin Li, Zi-Yi Han, Si-Xue Cheng, and Xian-Zheng Zhang*. Inhibition of tumor progression through the coupling of bacterial respiration with tumor metabolism. Angew. Chem. Int. Ed. 2020, 59, 21562-21570.
6. Qi-Wen Chen#, Qian-Ru Li#, Meng-Wei Cao, Jian-Hua Yan, and Xian-Zheng Zhang*. Hierarchy-assembled dual probiotics system ameliorates cholestatic drug-induced liver injury via gut-liver axis modulation. Adv. Sci. 2022, 9, 2200986.
7. Qi-Wen Chen#, Xin-Hua Liu#, Jin-Xuan Fan, Si-Yuan Peng, Jia-Wei Wang, Xia-Nan Wang, Cheng Zhang, Chuan-Jun Liu, and Xian-Zheng Zhang*. Self-mineralized photothermal bacteria hybridizing with mitochondria-targeted metal-organic frameworks for augmenting photothermal tumor therapy. Adv. Funct. Mater. 2020, 30, 1909806.
8. Qi-Wen Chen#, Meng-Wei Cao#, Ji-Yan Qiao, Qian-Ru Li and Xian-Zheng Zhang*. Integrated cascade catalysis of microalgal bioenzyme and inorganic nanozyme for anti-inflammation therapy. Nanoscale Horiz. 2023, 8, 489-498.
9.   Yu Chen#, Qi-Wen Chen#, Fang-Sheng Fu, Hui-Yun Gu, Aixi Yu,* and Xian-Zheng Zhang*. Bone Destruction-Chemotactic Osteoprogenitor Cells Deliver Liposome Nanomedicines for the Treatment of Osteosarcoma and Osteoporosis. ACS Nano 2024, 18, 29864-29879.
10. Jia-Wei Wang#, Qi-Wen Chen#, Guo-Feng Luo, Ping Ji, Zi-Yi Han, Wen-Fang Song, Wei-Hai Chen* and Xian-Zheng Zhang*. Interference of glucose bioavailability of tumor by engineered biohybrids for potentiating targeting and uptake of antitumor nanodrugs. Nano Lett. 2022, 22, 8735-8743.
11. Jia-Wei Wang#, Qi-Wen Chen#, Guo-Feng Luo, Zi-Yi Han, Wen-Fang Song, Juan Yang, Wei-Hai Chen*, and Xian-Zheng Zhang*. A self-driven bioreactor based on bacterium-metal-organic framework biohybrids for boosting chemotherapy via cyclic lactate catabolism. ACS Nano 2021, 15, 17870-17884.

1、国家自然科学基金，青年基金项目，52403216，活细菌生物材料交互调控肿瘤免疫代谢促进免疫治疗的研究，2025-01至2027-12，30万元，在研，主持
2、湖南省自然科学基金，青年基金项目，2024JJ6520，抗原自合成细菌原生质体疫苗的构建及肿瘤免疫治疗研究，2024-01至2026-12，5万元，在研，主持
3、中国博士后科学基金会，中国博士后特别资助（站前），2021TQ0250，功能化天然高分子组装功能协同多菌系统调节肠道菌群用于肠道疾病治疗，2021-01至2023-12，主持
4、中国博士后科学基金会，中国博士后面上资助，2022M712456，化学改性多糖组装微生物共生系统调节肠道菌群抑制结肠炎-癌转化，2022-06至2024-06，主持
5、湖北省人社厅，湖北省博士后创新研究岗位，2022-06至2024-06，主持
6、中国科学技术部，国家重点研发计划课题，2019YFA0905603，治疗消化系统疾病的人工合成菌群构建与验证，2020-01至2024-12，参与
7、国家自然科学基金委员会，重点项目，22135005，基于生物活性材料的肿瘤免疫与代谢微环境可视化诊疗系统，2022-01至2026-12，参与
8、国家自然科学基金委员会，面上项目，21878249，HIV专一快速荧光可视化检测研究，2019-01至2022-12，参与
9、国家自然科学基金委员会，面上项目，51872244，基于石墨烯、镍基LDHs及多聚组氨酸融合蛋白生物传界面的构建及应用，2019-01至2022-12，参与