精细化工

1）手性胺的催化合成
2）第一过渡系金属参与的催化反应研究

博士期间：
运用化学-酶法开发了一系列新型手性双烯配体，并以金属铑络合形成了一类高活性，高效率催化剂，将芳基硼酸转金属化后不对称加成到贫电子不饱和烯烃。基于此类催化剂的特殊性质，首次观察到了配体电负性对手性选择性显著的效应，为后续催化剂的设计起到了重要的影响（Angew. Chem. Int. Ed., 2010, 49, 2750-2754）。
博后期间：
首次发现了一价铑催化的亲核性不对称烯丙基加成反应（Angew. Chem., Int. Ed., 2012, 51, 8309-8313）。开发了一类具有超高活性的硼基对贫电子共轭二烯的高化学选择性，高手性选择性的加成反应，获得高附加值的手性烯丙基硼酸酯或是烯丙基醇化合物。在实验室规模的反应中，底物与催化剂之比可以高达20000 ：1，以我们目前所了解的第一过渡系金属催化的不对称反应中，这是目前底物与催化剂之比最高的记录，初步具备了工业应用前景（Angew. Chem., Int. Ed., 2014, 53, 4186-4190）。

1. Enantioselective Synthesis of Allylboronates and Allylic Alcohols by Copper-Catalyzed 1,6-Boration, Luo, Y.; Roy, D. I.; Madec, A. G. E.; Lam, H. W. Angew. Chem., Int. Ed., 2014, 53, 4186-4190 (highlighted by SYNFACTS: 2014, (7), 0724);
2. Enantioselective Rhodium-Catalyzed Nucleophilic Allylation of Cyclic Imines with Allylboron Reagents, Luo, Y.; Hepburn, H. B.; Chotsaeng, N.; Lam, H. W. Angew. Chem., Int. Ed., 2012, 51, 8309-8313(highlighted by SYNFACTS: 2012, (11), 1210)
3. Enantioselective Rhodium-Catalyzed Addition of Potassium Alkenyltrifluoroborates to Cyclic Imines, Luo, Y.; Carnell, A. J.; Lam, H. W. Angew. Chem., Int. Ed., 2012, 51, 6762-6766 (highlighted by SYNFACTS: 2012, (10), 1133);
4. Chiral bicyclic [2.2.2] octadiene ligands for Rh-catalysed catalytic asymmetric conjugate additions to acyclic enones: a quantitative structure–property relationship, Luo, Y., Berry, N. G. and Carnell, A.. J., Chem. Commun., 2012, 48, 3279-3281 (featured as front cover research article);
5. Chemoenzymatic synthesis and application of 1,4-dimethyl substituted bicyclo[2.2.2] octadiene ligands - increased efficiency and tunability for rhodium-catalysed asymmetric conjugate additions, Luo, Y. and Carnell, A.. J., Angew. Chem. Int. Ed., 2010, 49, 2750-2754 (highlighted by SYNFACTS: 2010, (7), 0796).