生物医药

1.设计开发蛋白类、多肽类和纳米类药物，调控阿尔兹海默症相关致病蛋白—淀粉样β蛋白（Aβ）的聚集行为，研究抑制机理。
2.多功能纳米材料在疾病诊断、抑菌、抗炎等领域的开发和应用

(1) Wang Wenjuan; Lin Xiaoding; Dong Xiaoyan; Sun Yan ; A multi-target theranostic nanocomposite against Alzheimer's disease fabricated by conjugating carbon dots and triplefunctionalized human serum albumin, Acta Biomaterialia, 2022, 148: 298-309.
(2) Wang Wenjuan; Zhao Guangfu; Dong Xiaoyan; Sun Yan ; Unexpected Function of a Heptapeptide-Conjugated Zwitterionic Polymer that Coassembles into β-Amyloid Fibrils and Eliminates the Amyloid Cytotoxicity, ACS Applied Materials & Interfaces, 2021, 13(15): 18089-18099.
(3) Wang Wenjuan; Liu Miaomiao; Gao Weiqun; Sun Yan; Dong Xiaoyan ; Coassembled Chitosan–Hyaluronic Acid Nanoparticles as a Theranostic Agent Targeting Alzheimer’s β-Amyloid, ACS Applied Materials & Interfaces, 2021, 13(47): 55879-55889.
(4) Wang Wenjuan; Liu Wei; Dong Xiaoyan; Sun Yan; Design of multifunctional agent based on basified serum albumin for efficient in vivo β-amyloid inhibition and imaging, ACS Applied Bio Materials, 2020, 3: 3365-3377.
(5) Wang Wenjuan; Dong Xiaoyan; Sun Yan; Modification of serum albumin by high conversion of carboxyl to amino groups creates a potent inhibitor of amyloid β-protein fibrillogenesis, Bioconjugate Chemistry, 2019, 30: 1477-1488.

（1）国家自然科学基金青年项目，活性氧响应性溶酶体靶向多肽-聚合物的设计合成及其降解Aβ作用与机制研究，主持（No. 22207082）
（2）山西省基础研究计划（自由探索类）青年项目，铈掺杂碳点对淀粉样蛋白聚集的多功能诊疗作用，主持（No. 202103021223118）
（3）国家自然科学基金面上项目，设计多功能纳米马达强化对β淀粉样蛋白的解毒作用，参与（No. 21978207）
（4）天津市自然科学基金项目，基于人白蛋白构筑淀粉样β多肽聚集的多功能抑制剂，参与（No. 19JCZDJC36800）