研究成果:
1. 制药和结晶过程系统工程,基于晶型结构的群体粒数衡算模型模拟结晶器中晶体的生长,实现结晶过程中晶体多维形状分布的模拟以及组成的模拟;开在线三维图像获取和图像处理技术用于晶体生长过程中三维晶形结构的在线测量;基于上述突破,实现了结晶过程晶体群体形状分布的闭环自动控制。晶型筛选,智能自动化晶型筛选机器人开发。连续结晶、造粒、研磨设备的研发。
2. 制药工艺过程全流程的模拟、过程分析技术和控制技术的开发,包括合成、结晶、过滤、造粒、研磨、干燥和压片等;生物制药过程例如发酵和细胞培养等工艺的过程分析技术、控制和模拟技术的研究。
3. 在过程工业数据挖掘方面,提出了数据挖掘用于过程检测和控制,发表英文专著“数据挖掘和知识发现在过程检测和控制中的应用“(Data Mining and Knowledge Discovery for Process Monitoring and Control – Springer, London,New York,1999)。致力于大数据挖掘和应用于制药工艺的智能化和自动化制造。
4. 在纳米生产过程的在线测量、模拟及控制、放大和高通量新产品开发这一重要领域的相关研究上,研究开发括动态光散射、超声、近红外和过程层析成像仪器,和群体粒数衡算模型和计算流体力学模拟等。
5. 此外,研究工作还包括利用构效关系模型(SAR – structure activity relationship)预测纳米材料毒性。
论文著作:
1. Development of chemometric modelling in the application of NIR to the quality control of Chinese herbal medicine:literature review and future perspectives
Zhaolu ZHOU; Jie LI; Shengquan HUANG; Shuhua TIAN; Yujiao LIU; Liang LU; Yang ZHANG; Yansheng HUANG; Xuezhong WANG
化工进展, 2016
2. Development of chemometric models based on near infrared spectroscopy for on-line quality control of a Chinese herbal liquid tonic
Jingjing LI; Zhaolu ZHOU; Shengquan HUANG; Liang LU; Yansheng HUANG; Shuhua TIAN; Akinola FALOLA; Xuan LI; Jie LI; Yidan SHU; Xuezhong WANG
化工进展, 2018
3. Integrating on-line imaging with infrared spectroscopy technology to optimize the cefixime reactive crystallization process
Shuai Yu; Yang Zhang; Xue-zhong Wang
中国抗生素杂志, 2019
4. Study on Reactive Crystallization of Cerium Carbonate
LI Tian; ZHANG Yang; WANG Xue-zhong
稀土, 2020
5. Simulation and experimental study on the evolution of droplet size distribution during spray drying of mannitol
Feng Lü; Yang ZHANG; Caiyun MA; Xuezhong WANG
化工进展, 2019
6. Model building and transfer between spectrometers in the application of near infrared spectroscopy to online quality control of Chinese herbal liquid tonic
Liping HU; Shengquan HUANG; Shuhua TIAN; Yansheng HUANG; Liuyun HU; FALOLA A; Xuan LI; Yidan SHU; Xue WANG
化工进展, 2020
7. Preparation of pharmaceutical nanocrystals using wet nanomilling—Hydrotalcite
王小康; FALOLA Akinola; 何运良; 张扬; 王学重
化工进展, 2021
8. Progress of On-line Monitoring Technologies and Process Simulation of Drug Coating
ZHANG Ran; LI Meng; YU Weiyong; WANG Xuezhong; WU Tao
中国医药工业杂志, 2023