生物医药

多糖及多肽类药物研发

1. Liu Q, Jia SX, Chi QN, Lin L, Chen XQ, Li J, Qi YK*, Du SS*. Efficient synthesis, stability-guided optimization and anticancer evaluation of bee venom peptide Melittin, [J] Bioorg. Chem., 2025, 159, 108344.
2. Chen XQ, Cui SS, Chen YZ, Wang CY, Liu Q, Qi YK*, Du SS*. Efficient delivery of oncolytic peptide LTX-315 by ZIF-8: pH-responsive release, improved stability, and reduced hemolysis, [J] Mol. Pharmaceutics, 2025, 22, 1449.
3. Xu H, Fu XY, Bao YX, Zhu SY, Xu Z, Song M, Qi YK*, Li Z* Du SS*. D-type peptides based fluorescent probes for “turn on” sensing of heparin, [J] Bioorg. Chem., 2024, 147, 107356.
4. Yin H, Chen XT, Chi QN, Ma YN, Fu XY, Du SS*, Qi YK*, Wang KW*. The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus, [J] Acta Pharmacol. Sin., 2023, 44, 201.
5. Liu F#, Du SS#, Zhang W, Ma J, Wang S, Liu M*, Liu F*. Construction of zwitterionic porous organic frameworks with multiple active sites for highly efficient CO2 adsorption and synergistic conversion. [J] Chem. Eng. J., 2022, 435, 134921.
6. Yan YS#, Du SS#, Ji Y, Su N, Wang Y, Mei X, Zhu W, He D, Lu Y, Zhang C, Xing XH*. Discovery of enzymatically depolymerized heparins capable of treating Bleomycin-induced pulmonary injury and fibrosis in mice. [J] Carbohydr. Polym., 2017, 174, 82.
7. Chi QN, Jia SX, Yin H, Wang L, Fu XY, Ma YN, Sun MP, Qi YK*, Li Z*, Du SS*. Efficient synthesis and anticancer evaluation of spider toxin peptide LVTX-8-based analogues with enhanced stability. [J] Bioorg. Chem., 2023, 134, 106451.
8. Du SS*, Wang S, Zhang J, He D, Chen X, Xu H, Song M, Su N, Qi YK, Zhao Y*, Li Z*. Significantly different fluorescent responses of two aggregation-induced emission probes to heparin. [J] Dyes Pigment., 2022, 207, 110767.
9. Dong J, Ping R, Dai X, Wang D, Liu F, Du SS*, Liu M*. Pyrrolidine-2,5-dione-derived ionic liquids promoted efficient transformation of flue gas CO2 into α-alkylidene cyclic carbonates at room temperature. [J] J. CO2 Util., 2022, 65, 102227.
10. Li YJ#, Fang CB#, Wang SS, Chen XQ, Li Y, Liu Q, Qi YK* Du SS* Design and synthesis of TH19P01-Camptothecin based hybrid peptides inducing effective anticancer responses on sortilin positive cancer cells, [J] Bioorg. Med. Chem., 2024, 111, 117869.
11. Song M, Liu Q, Yao JF, Wang YT, Ma YN, Xu H, Yu QY, Li Z*, Du SS*, Qi YK*. Synthesis and structural optimization of oncolytic peptide LTX-315, [J] Bioorg. Med. Chem., 2024, 107, 117760.
12. Yin H#, Chen XT#, Fu XY, Ma YN, Xu YM, Zhang T, Liang S, Du SS*, Qi YK*. Wang, K. W. Efficient Chemical Synthesis and Oxidative Folding Studies of Scorpion Toxin Peptide WaTx [J] Acta Chim. Sinica, 2022, 80, 444.
13. Yin H#, Fu XY#, Gao HY, Gao H, Ma Y, Chen X, Zhang X, Du SS*, Qi YK*. Hybrid peptide NTP-217 triggers ROS-mediated rapid necrosis in liver cancer cells by induction of mitochondrial leakage, [J] Front. Oncol., 2023, 12, 1028600.
14. Chen XT, Wang JY, Ma YN, Dong LY, Jia SX, Yin H, Fu XY, Du SS*, Qi YK*, Wang KW. DIC/Oxyma based accelerated synthesis and oxidative folding studies of centipede toxin RhTx, [J] J. Pept. Sci., 2022, 28, e3368.
15. Qi YK*, Tang X, Wei NN, Pang CJ, Du SS*, Wang KW. Discovery, synthesis, and optimization of teixobactin, a novel antibiotic without detectable bacterial resistance [J] J. Pept. Sci., 2022, 28, e3428.
16. Jia SX, Chi QN, Zhang Y, Liu T, Kou X, Wang F, Qi YK, Du SS*, Xing XH. Binding ability of methylene blue with heparin dependent on its sulfate level rather than its sulfation location or basic saccharide structure [J] Glycoconjugate J., 2021, 38, 551.
17. Wang JY#, Dong LY#, Liu YN, Chen XT, Ma YN, Yin H, Du SS*, Qi YK*, Wang KW, Efficient Synthesis and Oxidative Folding Studies of Centipede Toxin RhTx [J], Chin. J. Org. Chem., 2021, 41, 2800.
18. Du SS, Weiss C, Giese C, Kraemer S, Wehling M, Kraemer R, Harenberg J*. Determination of dabigatran concentrations in patient plasma, serum and urine samples: comparison of six methods [J]. Clin. Chem. Lab. Med., 2015, 53, 1237.
19. Du SS, Kraemer S, Giese C, Weiss C, Wehling M, Kraemer R, Harenberg J*. Chromogenic assays for measurement rivaroxaban from EDTA anticoagulated plasma samples [J]. Thromb. Haemost., 2015, 113, 1149.
20. Du SS, Harenberg J*. Kraemer S, Kraemer R, Wehling M, Weiss C. Measurement of non-vitamin K antagonist oral anticoagulants in patient plasma using Heptest-STAT coagulation method [J]. Ther. Drug Monit., 2015, 37, 375.
21. Du SS, Sang Q, Zhao N, Cui HF*. Study on the preparation of relative molecular mass calibrator for low molecular mass heparin [J], Chin. J. Anal. Chem., 2012, 32, 1976.
22. Du SS, Cui HF*. An introduction of methods for determination of relative molecular mass of low molecular weight heparin [J], Chin. J. Anal. Chem., 2011, 31, 402.

[1] 2024.11-2026.11，国家药监局糖药物质量研究与评价重点实验室开放课题，主持。
[2] 202101-202312，国自然青年科学基金项目，主持。
[3] 201907-202206，山东省自然科学博士基金，主持。
[4] 2016.01–2017.12，中国博士后基金，主持。