新材料,石油炼制,石油化工,精细化工,生物医药

具有四取代碳手性中心的不对称催化构建

Asymmetric Catalysis;Organocatalysis;Asymmetric Synthesis;Enantioselective Synthesis;Transition Metal Catalysis;Chiral Catalysts;Synthetic Methods;Enantioselective Fluorination;Enantioselective Reactions;Heterogeneous Catalysts

第一、发展了一种新的实现“协同催化”的策略：“副产物作为（助）催化剂”的串联反应，被同行认为是一个概念性的突破；开发了胺-膦酰胺新型手性双功能催化剂；利用手性双金络合物实现了首例金催化的烯烃与重氮化合物的不对称环丙烷化反应。
第二、围绕具有四取代碳手性中心的药物核心骨架如3,3-双取代氧化吲哚、螺环氧化吲哚、Cα-四取代氨基酸和叔醇等，发展了一系列不对称催化的新反应。例如，首次利用不对称催化的炔烃和叠氮的环加成反应，6π电环化反应和Morita-Baylis-Hillman（MBH）反应来构建四取代碳手性中心。

125) Y. Gong, Z. Zhang, H. Liu, T. Wang, M. Jiang, N. Feng, P. Peng, H. Wang, F. Zhou*, X. Wang*,  J. Zhou* Trifluoroethanol-assisted asymmetric propargylic hydrazination to  α-tertiary ethynylhydrazines enabled by sterically confined pyridinebisoxazolines Nat. Commun.2025, 16, 4571
https://www.nature.com/articles/s41467-025-59845-5
124) X.-X. Zhang, D.-L. Tang, X.-Z. Xie, Y. Gao, C. Ma, F. Zhou, J. Zhou*, J.-S. Yu*
Desymmetric Sulfonylation of Prochiral Siladiols and Related Tandem Sequences to Multifunctional Si-Chiral Platform Molecules Sci. China. Chem. 2025, in press
https://doi.org/10.1007/s11426-025-2720-1
123) J.-S. Tian, Y. Gong, Z.-W. Wu, J.-S. Yu*, Jian Zhou* H‐Bond Donor‐Directed Switch of Diastereoselectivity in the Enantioselective Intramolecular Aza‐Henry Reaction of Ketimines Chem. Eur. J. 2024, e202402488
122) Y. Gao, X.-X. Zhang, Z. Tu, J.-S. Yu*, J. Zhou* Diastereoselective Aldol Reaction of α-Azido Ketones with α-CF3 Pyruvate to Organoazides with Vicinal Tetrasubstituted Carbons Eur. J. Org. Chem. 2024, 27,e202400348
121) Z. Zhang, Y. Sun, Y. Gong, D.-L. Tang, H. Luo, Z.-P. Zhao, F. Zhou*, X. Wang* & J. Zhou* Enantioselective propargylic amination and related tandem sequences to α-tertiary ethynylamines and azacycles Nat. Chem. 2024, 16, 521.
120) P.-W Xu, F. Zhou*, L. Zhu* & J. Zhou* Catalytic desymmetrization reactions to synthesize all-carbon quaternary stereocentres Nature Synthesis 2023, 2, 1020-1036.
119) Y. Gao, X.-X. Zhang, J.-S. Yu, J. Zhou* Recent Advances in Catalytic Enantioselective Synthesis of α -Chiral Tertiary Azides Acta Chim. Sinica 2023, 81, 1590-1608.
118) J.-S. Tian, Z. Tu, F. Zhou, J.-S. Yu and J. Zhou* Tandem imine generation/N-cyclization/C-alkylation sequence to access N-functionalized indoles featuring an aza-quaternary carbon Org. Chem. Front.2023, 10, 1759.
117) Y. Gong, C. Wang, F. Zhou,* K. Liao, X.-Y. Wang, Y. Sun, Y.-X. Zhang, Z. Tu, X. Wang,* and J. Zhou* Sulfonyl-PYBOX Ligands Enable Kinetic Resolution of α-Tertiary Azides by CuAAC Angew. Chem. Int. Ed. 2023, e202301470.
116) C.-W. Lei, X.-Y. Wang, B.-S. Mu, J.-S. Yu,* Y. Zhou,* and J. Zhou* Me2(CH2Cl)SiCF3 Facilitated Tandem Synthesis of Oxasilacycles Featuring a Trifluoromethyl Group Org. Lett. 2022, 24, 8364−8369.
115) B.-W. Pan, Y. Shi, S.-Z. Dong, J.-X. He, B.-S. Mu, W.-B. Wu, Y. Zhou,* F. Zhou * and J. Zhou* Highly stereoselective synthesis ofspirocyclopropylthiooxindoles and biological evaluation Org. Chem. Front.2022, 9, 2640.
114) X.-Y Cui, F. Zhou,* H.-H. Wu,* J. Zhou* Asymmetric Tandem Reactions Achieved by Chiral Amine & Gold(I) Cooperative Catalysis, Chin. J. Org. Chem. 2022, 42, 3033-3050.
113) W.-B. Wu,X. Yu, J.-S. Yu, X. Wang*, W.-G. Wang* & J. Zhou* Constructing Tertiary Alcohols with Vicinal Stereocenters: Highly Diastereo- and Enantioselective Cyanosilylation of α-Branched Acyclic Ketones and Their Kinetic Resolution, CCS Chem. 2022, 4, 2140–2152.
112) B.-S. Mu, Y. Gao, F.-M. Yang, W.-B. Wu, Y. Zhang, X. Wang,* J.-S. Yu,* and J. Zhou* The Bifunctional Silyl Reagent Me2(CH2Cl)SiCF3 Enables Highly Enantioselective Ketone Trifluoromethylation and Related Tandem Processes Angew. Chem. Int. Ed. 2022, e202208861.
111) B.-S. Mu, Z.-H. Zhang, W.-B. Wu*, J.-S. Yu, J. Zhou* Recent Advances in Synthesis of Chiral 1,2-Dihydropyridines Acta Chim. Sinica 2021, 79, 685-693.
110) P.-W. Xu, X.-Y. Cui, C. Chen, F. Zhou, J.-S. Yu, Y.-F. Ao,* and J. Zhou* Enantioselective Synthesis of Cα-Tetrasubstituted N-Hydroxyl-α-amino Nitriles via Cyanation of Ketonitrones Using Me2(CH2Cl)SiCN, Org. Lett. 2021, 23, 8471−8476.
109) K Liao, Y. Gong, R.-Y. Zhu, C Wang, F. Zhou,* and J. Zhou* Highly Enantioselective CuAAC of Functional Tertiary Alcohols Featuring an Ethynyl Group and Their Kinetic Resolution Angew. Chem. Int. Ed.2021, 60, 8488 –8493.
108) X.-Y. Cui, Y.-L. Zhao, Y.-M. Chen, S.-Z. Dong,* F. Zhou, H.-H. Wu,* and J. Zhou* Au-Catalyzed Formal Allylation of Diazo(thio)oxindoles: Application to Tandem Asymmetric Synthesis of Quaternary Stereocenters, Org. Lett. 2021, 23, 4864-4869.
107) B.-S. Mu, X.-Y. Cui, X.-P. Zeng, J.-S. Yu and J. Zhou*Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste Nature Commun.2021, 12, 2219.
106) X.-S. Hu, J.-X. He, S.-Z. Dong, Q.-H. Zhao, J.-S. Yu and J. Zhou*Regioselective Markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes. Nature Commun. 2020, 11, 5500.
105) P.-G. Ding, X.-S. Hu, J.-S. Yu* and J. Zhou*Diastereodivergent Synthesis of α-Chiral Tertiary Azides through Catalytic Asymmetric Michael Addition.Org. Lett. 2020, 22, 8578-8583.
104) Y. Shi, B.‐W. Pan, J.‐S. Yu. Y. Zhou, J. Zhou*Recent Advances in Applying Carbonyl‐stabilized Phosphorus Ylides for Catalysis.ChemCatChem, 2021, 13, 129-139.
103) F. Zhou*, L. Zhu, B.-W. Pan, Y. Shi, Y.-L. Liu, J. Zhou*Catalytic enantioselective construction of vicinal quaternary carbon stereocenters. Chem. Sci. 2020, 11, 9341–9365.
102) W.-B. Wu, J.-S. Yu, J. Zhou*Catalytic Enantioselective Cyanation: Recent Advances and Perspectives ACS Catal. 2020, 10, 7668−7690.
101) Q. Xiao, J.-S. Yu, Y.-F. Wang, D.-J. Ma, J. Zhou* and X. Lou* 3-Difluoroalkyl Quaternary Oxindoles Inhibit Macrophage Pyroptosis by Blocking Inflammasome Recruitment of Caspase-1 ACS Med. Chem. Lett. 2020, 11, 1392−1401.
100) C. Wang, F. Zhou, J. Zhou*Recent Advances in the Enantioselective Copper(I)-Catalyzed Azide-Alkyne Cycloaddition Reaction Chin. J. Org. Chem. 2020, 40, 3065-3077.
99) F. Zhou*, J. Zhou*.Ni-Catalyzed Desymmetrization of Malononitriles to Cycloenones with a Nitrile-Containing All-Carbon Quaternary Center Chin. J. Org. Chem. 2020, 40, 2180-2181.
98) P.-G. Ding, F. Zhou, X. Wang, Q.-H. Zhao, J.-S. Yu and J. Zhou*. H-Bond donor-directed switch of diastereoselectivity in the Michael addition of α-azido ketones to nitroolefins. Chem. Sci. 2020, 11, 3852-3861.
97) C. Chen, W.-B. Wu, Y.-H. Li, Q.-H. Zhao, J.-S. Yu, J. Zhou*Activation of Chiral (Salen)TiCl2 Complex by Phosphorane for the Highly Enantioselective Cyanation of Nitroolefins. Org. Lett. 2020, 22, 2099−2104.
96) W.-B. Wu, X.-P. Zeng, J. Zhou*Carbonyl-Stabilized Phosphorus Ylide as an Organocatalyst for Cyanosilylation Reactions Using TMSCN. J. Org. Chem. 2020, 85, 14342-14350.
95) R.-Y. Zhu, K. Liao, J.-S. Yu and J. Zhou* Recent Advances in Catalytic Asymmetric Synthesis of P-Chiral Phosphine Oxides Acta Chim. Sinica 2020, 78, 193-216.
94) C. Wang, R.-Y. Zhu, K. Liao, F. Zhou, J. Zhou* Enantioselective Cu(I)-Catalyzed Cycloaddition of Prochiral Diazides with Terminal or 1-Iodoalkynes. Org. Lett. 2020‚ 22, 1270-1274.
93) Y.-H. Wang, Z.-Y. Cao, Q.-H. Li, G.-Q. Lin, J. Zhou* and P. Tian* Activating Pronucleophiles with High pKa Values: Chiral Organo-Superbases. Angew. Chem. Int. Ed. 2020, 59, 8004-8014.
92) Y.-H. Wang, J.-S. Tian, P.-W. Tan, Q. Cao, X.-X. Zhang, Z.-Y. Cao, F. Zhou, X. Wang, and J. Zhou* Regiodivergent Intramolecular Nucleophilic Addition of Ketimines for the Diverse Synthesis of Azacycles. Angew. Chem. Int. Ed. 2020, 59, 1634 –1643.
91）R.-Y. Zhu, L. Chen, X.-S. Hu, F. Zhou and J. Zhou* Enantioselective synthesis of P-chiral tertiaryphosphine oxides with an ethynyl group via Cu(I)-catalyzed azide–alkyne cycloaddition. Chem. Sci. 2020, 11, 97–106.
90) S.-L. Xie, X.-T Gao, F. Zhou, H.-H. Wu, J. Zhou* Enantioselective carboxylative cyclization of propargylic alcohol with carbondioxide under mild conditions. Chin. Chem. Lett. 2020, 31, 324–328.
89) Y. Gong, Z.-Y. Cao, Y.-B. Shi, F. Zhou, Y. Zhou and J. Zhou* A highly efficient Hg(OTf)2-mediated Sakurai–Hosomiallylation of N-tert butyloxycarbonylamino sulfones, aldehydes, fluoroalkylketones and α,β-unsaturated enones usingallyltrimethylsilane. Org. Chem. Front. 2019, 6, 3989–3995.
88) Y.-P. Tian, Y. Gong, X.-S. Hu, J.-S. Yu, Y. Zhou and J. Zhou*HClO4 catalysed aldol-type reaction of fluorinated silyl enol ethers with acetals or ketalstoward fluoroalkyl ethers. Org. Biomol. Chem. 2019, 17, 9430–9434.
87) X.-S. Hu, J.-S. Yu and J. Zhou* Catalytic selective mono- and difluoroalkylation using fluorinated silyl enol ethers. Chem.Commun. 2019, 55, 13638-13648.
86) X.-T. Gao, S.-L. Xie, F. Zhou, H.-H. Wu and J. Zhou* Multifunctional 1,3-diphenylguanidine for the carboxylativecyclization of homopropargyl amines with CO2 under ambient temperature and pressure. Chem. Commun. 2019, 55, 14303-14306.
85) S.-L. Xie, X.-Y. Cui, X.-T. Gao, F. Zhou, H.-H. Wu and J. Zhou* Stereoselective defluorinative carboxylation of gem-difluoroalkenes with carbon dioxide. Org. Chem. Front. 2019, 6, 3678-3682.
84) P.-W. Xu, J.-S. Yu,* C. Chen, Z.-Y. Cao, F. Zhou and J. Zhou*. Catalytic Enantioselective Construction of Spiro Quaternary Carbon Stereocenters. ACS Catalysis 2019, 9, 1820-1882.
83) K. Liao, X.-S. Hu, R.-Y. Zhu, R.-H. Rao, J.-S. Yu, F. Zhou and J. Zhou* Catalytic Enantioselective Protonation of Monofluorinated Silyl Enol Ethers towards Chiral α-Fluoroketones. Chin. J. Chem. 2019, 37, 799-806.
82) Y.-J.Hao, Y. Gong, Z.-Y Cao, Y. Zhou, J. Zhou* A highly efficient In(OTf)3-catalyzed[3+3] annulation of spirocyclopropyl oxindoles with 1,4-di-thiane-2,5-diol. Chin. Chem. Lett.2020, 31, 681-684.
81) X.-S Hu, P.-G. Ding, J.-S. Yu and J. Zhou* A Sc(OTf)3 catalyzed Mukaiyama–Mannich reaction of difluoroenoxysilanes with unactivatedketimines. Org. Chem. Front. 2019, 6, 2500-2505.
80) Y. Gong, J.-S. Yu, Y.-J. Hao, Y. Zhou, J. Zhou* Catalytic Enantioselective Aldol-Type Reaction Using α-Fluorinated Enolates. Asian J. Org. Chem. 2019, 8, 610–626.
79) X.-S. Hu, J.-S. Yu,* Y. Gong, J. Zhou*Internally reuse by-product as promoter: A catalyst-free imine formation/Mukaiyama-Mannich sequence of α-amido sulfones with fluorinated silyl enol ethers. J. Fluorine Chem. 2019, 219, 106-114.
78) Y.-J. Hao, J.-S. Yu, Y. Zhou, W. Wang, J. Zhou*C―F…H―X相互作用在有机反应中的影响(Influence of C—F…H—X Interactions on Organic Reactions) Acta Chim. Sinica 2018, 76, 925—939
77) Y.-J. Hao, X.-S. Hu, J.-S. Yu, Y. Zhou*, F. Zhou, J. Zhou*An efficient Fe(III)-catalyzed 1,6-conjugate addition of para-quinone methides with fluorinated silyl enol ethers toward β,β-diaryl α-fluorinated ketones.Tetrahedron 2018, 74, 7395-7398.
76) F.-M. Liao, Y. Du, F. Zhou, J. Zhou* Au(I)/手性双功能叔胺催化实现的一锅法串联成烯/不对称环化反应构建螺环季碳氧化吲哚(Au(I)/Chiral Tertiary Amine Catalyzed Tandem Olefination/Asymmetric Cyclization Reaction to Quaternary Spirocyclic Oxindoles) Acta Chim. Sinica 2018, 76, 862—868.
75) Z.-Y. Cao, W. Wang, K. Liao, X. Wang, J. Zhou* and J. Ma* Catalytic enantioselective synthesis of cyclopropanes featuring vicinal all-carbon quaternary stereocenters with a CH2F group; study of the influence of C–F⋯H–N interactions on reactivity Org. Chem. Front. 2018, 5, 2960-2968.
74) P.-W. Xu, C. Chen, J.-K. Liu, Y.-T. Song, F. Zhou, J. Yan and J. Zhou* One-Pot Sequential [3 + 3] Dipolar Cycloaddition of Aldehyde or Ketone and Hydroxylamine with Spirocyclopropyl Oxindole.J. Org. Chem. 2018, 83, 12763-12774
73) Z.-Y. Cao, F. Zhou and J. Zhou* Development of Synthetic Methodologies via Catalytic Enantioselective Synthesis of 3,3-Disubstituted Oxindoles Acc. Chem. Res. 2018, 51, 1443-1454.
72) P.-G. Ding, X.-S. Hu, F. Zhou and J. Zhou* Catalytic enantioselective synthesis of α-chiral azidesOrg. Chem. Front. 2018, 5, 1542-1559.
71) Y.-L. Liu, X.-P. Yin, J. Zhou* Internally Reuse Waste: Catalytic Asymmetric One-Pot Strecker Reaction of Fluoroalkyl Ketones, Anilines and TMSCN by Sequential Catalysis Chin. J. Chem. 2018, 36, 321-328.
70) X.‐P. Yin, L. Zhu, J. Zhou* Metal‐Free Azidation of α‐Hydroxy Esters and α‐Hydroxy Ketones Using Azidotrimethylsilane Adv. Synth. Catal. 2018, 360, 1116-1122.
69) X.-T. Gao, C.-C. Gan, S.-Y. Liu, F. Zhou*, H.-H. Wu,* J. Zhou* Utilization of CO2 as a C1 Building Block in a Tandem Asymmetric A3 Coupling-Carboxylative Cyclization Sequence to 2-Oxazolidinones ACS Catal. 2017, 7, 8588-8593.
68) F.-M. Liao,X.-T. Gao, X.-S. Hu, S.-L. Xie, J. Zhou*A general and efficient Lewis acid catalysed Mukaiyama-aldol reaction of difluoroenoxysilanes and ketones. Sci. Bull. 2017, 62, 1504-1509.
67) P.-W. Xu, J.-K. Liu,L. Shen, Z.-Y. Cao, X.-L. Zhao, J. Yan,* J. Zhou*Diastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones. Nature Communications, 2017, 8, 1619.
66) F.Zhou,* S.-L.Xie, X.-T.Gao, R. Zhang,* C.-H.Wang, G.-Q.Yin, J. Zhou* Activation of (salen)CoI complex by phosphorane for carbon dioxide transformation at ambient temperature and pressure. Green Chem. 2017, 19, 3908-3915.
65) F.-M. Liao, J.-S. Yu and J. Zhou* Recent Advances in the Highly Stereoselective Synthesis of Tri- or Tetra-substituted Monofluoroalkenes Chin. J. Org. Chem.2017, 37, 2175-2186.
64) X.-S. Hu, Y. Du, J.-S. Yu,* F.-M. Liao, P.-G. Ding and J. Zhou* A Highly Efficient Gold(I)-Catalyzed Mukaiyama–Mannich Reaction of α-Amino Sulfones with Fluorinated Silyl Enol Ethers To Give β-Amino α-Fluorinated Ketones Synlett 2017, 16, 2194-2198.
63) F.-M. Liao, Z-Y. Cao, J.-S. Yu and J. Zhou* Highly Stereoselective Gold-Catalyzed Coupling of Diazo Reagents and Fluorinated Enol Silyl Ethers to Tetrasubstituted Alkenes Angew. Chem. Int. Ed. 2017‚ 56,2459-2463.
62) X. Ye, X.-P. Zeng, J. Zhou* Me2(CH2Cl)SiCN和Me3SiCN在醛的不对称氰化反应中的比较研究, Acta Chim. Sinica 2016, 74, 984-989
61) Y.-H. Wang, Z.-Y. Cao, J. Zhou* Nucleophilic Difluoromethylenation of Ketones Using Diethyl Difluoro(trimethylsilyl)methylphosphonate Mediated by 18-Crown-6 Ether/KOAc. J. Org. Chem.2016,  81, 7807-7816.
60) X.-P. Zeng, J. Zhou* Me2(CH2Cl)SiCN: Bifunctional Cyanating Reagent for the Synthesis of Tertiary Alcohols with a Chloromethyl Ketone Moiety via Ketone Cyanosilylation. J. Am. Chem. Soc. 2016, 138, 8730-8733. Highlighted by http://www.x-mol.com/news/3137, 双功能硅氰化试剂的设计、合成及在(S)-CPB pheromone全合成中的应用
59) J.-S. Yu, H.-M. Huang, P.-G. Ding, X.-S. Hu, F. Zhou, J. Zhou* Catalytic Enantioselective Construction of Sulfur-Containing Tetrasubstituted Carbon StereocentersACS Catal. 2016, 6, 5139-5144.
58)  X.-P. Zeng, Z.-Y. Cao, Y.-H.Wang, F. Zhou, J. Zhou* Catalytic Enantioselective Desymmetrization Reactions to All-Carbon Quaternary Stereocenters. Chem. Rev. 2016. 116, 7330.
57) Y.-L. Zhao, Z.-Y. Cao, X.-P. Zeng, J.-M. Shi, Y.-H. Yu and J. Zhou* Asymmetric sequential Au(I)/chiral tertiary amine catalysis: an enone-formation/cyanosilylation sequence to optically active 3-alkenyloxindoles from diazooxindoles. Chem. Commun. 2016, 52, 3643-3646.
56) J.-S. Yu, J. Zhou* Organocatalytic enantioselective Mukaiyama–Mannich reaction of fluorinated enol silyl ethers and cyclicN-sulfonyl ketimines. Org. Chem. Front. 2016, 3, 298-303.
55) Z.-Y. Cao, Y.-L. Zhao, J. Zhou* Sequential Au(I)/chiral tertiary amine catalysis: a tandem C–H functionalization of anisoles or a thiophene/asymmetric Michael addition sequence to quaternary oxindoles. Chem. Commun. 2016, 52, 2537
54) Z.-Y. Cao, J.-S. Jiang, J. Zhou* A highly enantioselective Hg(II)-catalyzed Sakurai–Hosomi reaction of isatins with allyltrimethylsilanes. Org. Biomol. Chem. 2016, 14, 5500-5504 (invited for New Talent Issue).
53) X.-P. Zeng, Z.-Y. Cao, X. Wang, L. Chen, F. Zhou, F. Zhu, C.-H. Wang, J. Zhou* Activation of Chiral (Salen)AlCl Complex by Phosphorane for Highly Enantioselective Cyanosilylation of Ketones and Enones. J. Am. Chem. Soc. 2016, 138, 416-425.
52) J.-S. Yu, J. Zhou* A highly efficient Mukaiyama–Mannich reaction of N-Boc isatin ketimines and other active cyclic ketimines using difluoroenol silyl ethers catalyzed by Ph3PAuOTf. Org. Biomol. Chem. 2015, 13, 10968 (Feature article).
51) J.-S. Yu, F. Zhou, Y.-L. Liu, J. Zhou* A Journey in the Catalytic Synthesis of 3-Substituted 3-Aminooxindoles. Synlett 2015, 26, 2491-2504. (invited account)
50) Z.-Y. Cao, J. Zhou* Catalytic asymmetric synthesis of polysubstituted spirocyclopropyl oxindoles: organocatalysisversustransition metal catalysis. Org. Chem. Front. 2015, 2, 849-858.
49) F.-M. Liao, Y.-L. Liu, J.-S. Yu, F. Zhou, J. Zhou* An efficient catalyst-free Mukaiyama-aldol reaction of fluorinated enol silyl ethers with tryptanthrin. Org. Biomol. Chem. 2015,13, 8906-8911.
48) X.-P. Yin, P.-W. Xu, K. Dong, K. Liao, F. Zhou, J. Zhou* Ga(OTf)3催化的3-羟基氧化吲哚与TMSN3的取代反应研究. Acta Chim. Sinica, 2015, 73, 685-689.
47) J.-S. Yu, F.-M. Liao, W.-M. Gao, K. Liao, R.-L. Zuo and J. Zhou* Michael Addition Catalyzed by Chiral Secondary Amine Phosphoramide Using Fluorinated Silyl Enol Ethers: Formation of Quaternary Carbon Stereocenters. Angew. Chem. Int. Ed. 2015‚ 54, 7381.
46)  L. Chen, Y. Du, X.-P. Zeng, T.-D. Shi, F. Zhou and J. Zhou* Successively Recycle Waste as Catalyst: A One-Pot Wittig/1,4-Reduction/Paal–Knorr Sequence for Modular Synthesis of Substituted Furans. Org. Lett. 2015‚ 17,  1557. (Highlighted by Organic Chemistry Portal  http://www.organic-chemistry.org/abstracts/lit4/873.shtm)
45) Zhu, P.-W. Xu, F. Zhou, C.-H. Wang* and J. Zhou* Recycle Waste Salt as Reagent: A One-Pot Substitution/Krapcho Reaction Sequence to α-Fluorinated Esters and Sulfones.Org. Lett. 2015‚ 17, 972.
44) Y.-L. Liu, J. Zhou* Catalytic Asymmetric Strecker Reaction: Bifunctional Chiral Tertiary Amine/Hydrogen-Bond Donor Catalysis Joins the Field. Synthesis, 2015, 1210-1226 (invited mini-review)
43) W.-M. Gao, J.-S. Yu, Y.-L. Zhao, Y.-L. Liu, F. Zhou, H.-H. Wu,* J. Zhou*Highly enantioselective Michael addition of 3-arylthio- and 3-alkylthiooxindoles to nitroolefins catalyzed by a simple cinchona alkaloid derived phosphoramide. Chem. Commun.2014, 50, 15719.
42) X.-P. Yin, X.-P. Zeng, Y.-L. Liu, F.-M. Liao, J.-S. Yu, F. Zhou, J. Zhou* Asymmetric Triple Relay Catalysis: Enantioselective Synthesis of Spirocyclic Indolines through a One-Pot Process Featuring an Asymmetric6π Electrocyclization. Angew. Chem. Int. Ed. 2014‚ 53, 13740.
41) F. Zhou, F.-M. Liao, J.-S. Yu, J. Zhou*Catalytic Asymmetric Electrophilic Amination Reactions To Form Nitrogen-Bearing Tetrasubstituted Carbon Stereocenters. Synthesis, 2014, 46, 2983-3003.(Invited focus review).
40) J.-S. Yu, Y.-L. Liu, J. Tang, X. Wang,* J. Zhou* Highly Efficient “On Water” Catalyst-Free Nucleophilic Addition Reactions Using Difluoroenoxysilanes: Dramatic Fluorine Effects. Angew. Chem. Int. Ed. 2014‚ 53, 9512-9516.
39)Y.-L. Liu, F.-M. Liao, Y.-F. Niu, X.-L. Zhao, J. Zhou*  Highly stereoselective construction of adjacent tetrasubstituted carbon stereogenic centres via organocatalytic Mukaiyama-aldol reaction of monofluorinated silyl enol ethers to isatins. Org. Chem. Front. 2014, 1, 742-747.
38) L. Chen, X.-P. Yin, C.-H. Wang, J. Zhou* Catalytic functionalization of tertiary alcohols to fully substituted carbon centres. Org. Biomol. Chem. 2014‚ 12, 6033-6048(Invited review)
37) Y.-H. Wang, Z.-Y. Cao,Y.-F. Niu, X.-L. Zhao, J. Zhou*高对映选择性的有机催化的硝基烷烃对N-Boc靛红亚胺的不对称aza-Henry反应 Acta Chim. Sinica.,2014, 72, 867-872.  (Invited for special issue on organocatalysis)
36）Z.-Y. Cao, Y.-H. Wang, X.-P. Zeng, J. Zhou* Catalytic asymmetric synthesis of 3,3-disubstituted oxindoles: diazooxindole joins the field. Tetrahedron Lett. 2014, 55, 2571-2584(Invited Digest Paper).
35) Y.-H. Wang, Y.-L. Liu, Z.-Y. Cao, J. Zhou*An Organocatalytic Addition of Nitromethane to Activated Ketimines. Asian J. Org. Chem. 2014, 3, 429-432. (Invited for special issue on organocatalysis)
34) Y.-L. Liu, X. Wang, Y.-L. Zhao, F. Zhu, X.-P. Zeng,L. Chen, C.-H. Wang, X.-L. Zhao, J. Zhou* One-Pot Tandem Approach to Spirocyclic Oxindoles Featuring Adjacent Spiro-Stereocenters. Angew. Chem. Int. Ed.2013‚ 52‚ 13735-13739. （Highlighted by Synfacts 2014‚ 10, 204）
33) L. Chen, F. Zhu, H.-C. Wang,* J. Zhou*  A highly efficient thiourea catalyzed dehydrative nucleophilic substitution reaction of 3-substituted oxindoles with xanthydrols. RSC Adv. 2013,3, 19880-19884.
32) F. Zhou, C. Tan, J. Tang, Y.-Y. Zhang, W.-M. Gao, H.-H. Wu, Y.-H. Yu and J. Zhou* Asymmetric Copper(I)-Catalyzed Azide–Alkyne Cycloaddition to Quaternary Oxindoles. J. Am. Chem. Soc. 2013‚ 135‚ 10994-10997
31）刘运林、朱锋、王翠红、周剑* 3-羟基氧化吲哚的不对称合成:金属催化vs有机催化《有机化学》,2013，33, 1595-1615 (邀请综述）。
30) Z.-Y. Cao, X. Wang, C. Tan, X.-L. Zhao, J. Zhou* and K. Ding Highly Stereoselective Olefin Cyclopropanation of Diazooxindoles Catalyzed by a C2-Symmetric Spiroketal Bisphosphine/Au(I) Complex. J. Am. Chem. Soc. 2013‚ 135‚ 8197-8200.
29) C.-B. Ji, Z.-Y. Cao, X. Wang,* D.-Y. Wu and J. Zhou*  A Catalyst-Free, One-Pot Three-Component Aminomethylation of α-Substituted Nitroacetates: Theoretical and Experimental Studies into the Rate-Accelerating Effects of the Solvent Methanol. Chem. Asian. J. 2013, 8, 877.
28) F. Zhou, X.-P. Zeng, C. Wang, X.-L. Zhao and J. Zhou* Organocatalytic asymmetric synthesis of 3,3-disubstituted oxindoles featuring two heteroatoms at C3 position. Chem. Commun. 2013, 49, 2022-2024.
27) Y.-L. Liu, J.-S. Yu, J Zhou* Catalytic Asymmetric Construction of Stereogenic Carbon Centers that Feature a gem-Difluoroalkyl Group. Asian J. Org. Chem. 2013, 2, 194-206. (Invited focus review)
26) L. Chen, T.-D. Shi, J, Zhou* Waste as Catalyst: Tandem Wittig/Conjugate Reduction Sequence to α-CF3 γ-Keto Esters That Uses Ph3PO as Catalyst for the Chemoselective Conjugate Reduction. Chem. Asian. J.2013, 8, 556-559. (Highlited by Synfacts 2013‚ 9‚ 559)
25) Z.-Y. Cao, F. Zhou, Y.-H. Yu, J. Zhou* A Highly Diastereo- and Enantioselective Hg(II)-Catalyzed Cyclopropanation of Diazooxindoles and Alkenes. Org. Lett. 2013‚ 15, 42. (Highlited by Synfacts 2013‚ 9‚ 415).
24) X.-P. Zeng, Y.-L. Liu, C.-B. Ji, J. Zhou* The First Catalytic Asymmetric Morita-Baylis-Hillman Reaction of Acrolein with Aromatic Aldehydes. Chin. J. Chem. 2012, 30, 2631-2635 (邀请封面文章)
23) Y.-L. Liu, J. Zhou* Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines. Chem. Commun.2013‚ 49, 4421. (Invited for themed issue for 2013 Emerging Investigator). (Highlited by Synfacts 2013‚ 9‚ 96).
22) L. Chen,  J. Zhou*A Highly Efficient Friedel–Crafts Reaction of Tertiary α-Hydroxyesters or α-Hydroxyketones to α-Quaternary Esters or Ketones. Chem. Asian J.2012‚ 7‚ 2510-2515. (VIP paper).Highlighted by ChemViews Magzine http://www.chemistryviews.org/details/ezine/2656621/Catalytic_FriedelCrafts_for_Quaternary_Carbonyl_Compounds.html
21) F. Zhu, F. Zhou, Z.-Y. Cao, C. Wang, Y.-X. Zhang, C.-H. Wang*, J. Zhou* A Facile Method for the Synthesis of 3-Substituted 3-(Alkylthio)oxindoles or 3-Alkoxyoxindoles. Synthesis, 2012, 3129-3144. (invited feature article).
20) J.-S. Yu, F. Zhou, Y.-L. Liu, J. Zhou* Organocatalytic asymmetric Michael addition of unprotected 3-substituted oxindoles to 1,4-naphthoquinone. Beilstein. J. Org. Chem. 2012, 8, 1360-1365. (invited paper for a Thematic Series entitled “Organocatalysis”)
19) Y.-L. Liu‚ X.-P. Zeng‚ J. Zhou* 高对映选择性的有机催化的二氟烯醇硅醚与β‚γ-不饱和-α-酮酸酯的不对称Mukaiyama-aldol 反应《化学学报》‚2012‚ 70‚ 1451-1456。
We report the first example of catalytic asymmetric reaction of difluoroenoxysilanes 1 and β‚γ-unsaturated α-ketoesters 2. In the presence of tertiary amine or tertiary amine-H-bonding donor bifunctional catalysts‚ it was found that the reaction selectively took place at the ketone moiety of ketoesters 2‚ and no conjugate reaction happened.Quinine derived urea catalyst 11 was identified as a powerful catalyst for this Mukaiyama-aldol reaction to furnishα-difluoroalkyl substituted tertiary alcohols in good to high yield (44-81%)‚with moderate to excellent enantioselectivity (72-96%).
18) Y.-L. Liu‚ X.-P. Zeng‚ J. Zhou*Ethylene Glycol: A Powerful Catalyst-Free Medium for C-C Bond-Forming ReactionsEthylene Glycol: A Powerful Catalyst-Free Medium for C-C Bond-Forming Reactions. Chem. Asian J.2012‚ 7‚ 1759-1763.
We report the use of ethylene glycol as a remarkable catalyst-free medium to accomplish a highly efficient Strecker reaction of α-CF2H or CF3 ketoimines and TMSCN‚ and the activation potency of ethylene glycol could be utilized for several reactions‚ including the first example of catalyst-free Morita-Baylis-Hillman reaction.
17) L. Chen‚ F. Zhou‚ T.-D. Shi‚ J. Zhou* Metal-Free Tandem Friedel–Crafts/Lactonization Reaction to Benzofuranones Bearing a Quaternary Center at C3 Position. J. Org. Chem. 2012‚ 77‚ 4354-4362. (Highlighted by Organic Chemistry Portal: www.organic-chemistry.org/abstracts/lit3/623.shtm )
A metal-free tandem Friedel-Crafts/Lactonization reaction to 3‚3-diaryl or 3-alkyl-3-aryl benzofuranones catalyzed by HClO4 was reported. A variety of tertiary α-hydroxy acid esters could readily react with substituted phenols to afford the desired products in rich diversity.The synthetic utility of the products was demonstrated by the synthesis of polycyclic compounds. 1H NMR studies supported that this tandem reaction proceeded via tandem Friedel-Crafts/lactonization sequence.
16) F. Zhou‚ M. Ding‚ J. Zhou* A Catalytic Metal-free Ritter Reaction to 3-Substituted 3-Aminooxindoles. Org. Biomol. Chem.2012‚ 10‚ 3178-3183.
15) Y.-L. Liu‚ J. Zhou* Organocatalytic asymmetric synthesis of 3-difluoroalkyl 3-hydroxyoxindoles. Chem. Commun.2012‚ 48‚ 1919-1921. (Highlited by Synfacts2012‚ 8‚ 332).
14) C.-B. Ji‚ Y.-L. Liu‚ X.-L. Zhao‚ Y.-L. Guo‚ H.-Y. Wang‚ J. Zhou*Direct amination of α-substituted nitroacetates using di-tert-butyl azodicarboxylate catalyzed by Hatakeyama’s catalyst β-ICD.Org. Biomol. Chem.2012‚ 10‚ 1158-1161.(Invited for themed issue for Organocatalysis)
13) F. Zhou‚ Z.-Y. Cao‚ J. Zhang‚ H. B. Yang‚ J. Zhou* A Highly Efficient Friedel–Crafts Reaction of 3-Hydroxyoxindoles and Aromatic Compounds to 3‚3-Diaryl and 3-Alkyl-3-aryloxindoles Catalyzed by Hg(ClO4)2⋅3H2O. Chem. Asian J.2012‚ 7‚ 233-241.
12) Z.-Y. Cao‚ Y. Zhang‚ C.-B. Ji‚ J. Zhou* A Hg(ClO4)2·3H2O Catalyzed Sakurai–Hosomi Allylation of Isatins and Isatin Ketoimines Using Allyltrimethylsilane. Org. Lett. 2011‚ 13‚ 6398-6401.
11) C.-B. Ji‚ Y.-L. Liu‚ Z.-Y. Cao‚ Y.-Y. Zhang‚ J. Zhou* Hydroxymethylation of α-substituted nitroacetates. Tetrahedron Lett. 2011‚ 52‚ 6118-6121.
10）F. Zhou‚ M. Ding‚ Y.-L. Liu‚ C.-H. Wang‚ C.-B. Ji‚ Y.-Y. Zhang, J. Zhou* Organocatalytic Asymmetric α-Amination of Unprotected 3-Aryl and 3-Aliphatic Substituted Oxindoles using Di-tert-butyl Azodicarboxylate (pages 2945–2952)Adv. Syn. Catal. 2011‚ 353‚ 2945-2952.
9) M. Ding‚ F. Zhou‚ Y.-L. Liu‚ C.-H. Wang‚ X.-L. Zhao‚ J. Zhou* Cinchona alkaloid-based phosphoramide catalyzed highly enantioselective Michael addition of unprotected 3-substituted oxindoles to nitroolefins. Chem. Sci. 2011‚ 2‚ 2035-2039. (Highlighted by Synfact 2011‚ 1245）
8) Y.-L. Liu‚ T.-D. Shi‚ F. Zhou‚ X.-L. Zhao‚ X. Wang‚* J. Zhou* Organocatalytic Asymmetric Strecker Reaction of Di- and Trifluoromethyl Ketoimines. Remarkable Fluorine Effect. Org. Lett.2011‚ 13‚ 3826-3829. (Highlighted by Synfact 2011‚ 1015）
7）Y.-L. Liu‚ B.-L. Wang‚ J.-J. Cao‚ L. Chen‚ Y.-X. Zhang‚ C. Wang‚ J. Zhou* Organocatalytic Asymmetric Synthesis of Substituted 3-Hydroxy-2-oxindoles via Morita−Baylis−Hillman Reaction. J. Am. Chem. Soc. 2010‚ 132‚ 15176-15178.（Highlighted by Synfact 2010‚ 1422）
6) Y.-L. Liu‚ F. Zhou‚ J.-J. Cao‚ C.-B. Ji‚ M. Ding‚ J. Zhou* A facile method for the synthesis of oxindole based quaternary α-aminonitriles via the Strecker reaction. Org. Biomol. Chem.2010‚ 8‚ 3847-3850. (本文为封面文章)
5）J.-J. Cao‚ F. Zhou‚ J. Zhou* Improving the Atom Efficiency of the Wittig Reaction by a “Waste as Catalyst/Co-catalyst” Strategy (pages 4976–4980). Angew. Chem. Int. Ed.2010‚ 49‚ 4976-4980.
4）F. Zhou‚ Y.-L. Liu‚ J. Zhou* Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position (pages 1381–1407). Adv. Syn. Catal. 2010‚ 352‚ 1381-1407.
3）M. Ding‚ F. Zhou‚ Z.-Q. Qian‚ J. Zhou* Organocatalytic Michael addition of unprotected 3-substituted oxindoles to nitroolefins. Org. Biomol. Chem. 2010‚ 8‚ 2912-1914.
2) J. Zhou* Recent Advances in Multicatalyst Promoted Asymmetric Tandem Reactions Chem. Asian J. 2010‚ 5‚422-434.
1) Z.-Q. Qian‚ F. Zhou‚ T.-P. Du‚ M. Ding‚ B.-L. Wang‚ X.-L. Zhao‚ J. Zhou* Asymmetric construction of quaternary stereocenters by direct organocatalytic amination of 3-substituted oxindoles. Chem. Commun. 2009‚ 6753-6755.

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