精细化工

绿色合成、不对称催化

[21] Song, Ling-Jie; Zhang, Xiao-Dong; Jin, Zheng-Hao; Liang, Ren-Xiao;* Jia, Yi-Xia;* Iron- Catalyzed Dearomatizing Reductive Cyclization of Arenes, Organic Letters, 2025, 27(6): 1390–1395.
[20] Liang, Ren-Xiao;* Cai, Hu-Jie; Mao, Ming-Hua; Bai, Xue-Pei; Du, Bao-Yu; Jia, Yi-Xia;* Copper-Catalyzed Dearomative [3+2] Annulation of Indoles with 2-Iodoacetic Acid, Organic Letters, 2024, 26(45): 9631–9636.
[19] Liang, Ren-Xiao;* Xie, Jia-Qi; Cai, Hu-Jie; Sun, Shuo; Wang, Jia-Yi; Deng, Wei-Chao; Jia, Yi-Xia;* Enantioselective Desymmetrization of 1,3-Dicarbonyl Compounds through Transition-Metal-Catalyzed Intramolecular Cyclization Reactions, ChemCatChem, 2024, 16(20): e202400947.
[18] Liang, Ren-Xiao;* Ding, Chao; Cai, Hu-Jie; Wang, Jia-Yi; Li, Qi-Chuang; Yu, Gao-Yang; Jia, Yi-Xia;* Pd-Catalyzed Enantioselective Desymmetrizing 1,7-Enyne Cycloisomerization of Alkyne-Tethered Cyclopentenes, Organic Letters, 2024, 26(20): 4400–4405.
[17] Jin, Cheng-An; Liang, Ren-Xiao;* Jia, Yi-Xia;* Silver-Catalyzed Dearomative [3+2] Spiroannulation of Aryl Oxamic Acids with Alkynes, Synthesis, 2024, 56(20): 3191–3198.
[16] Xie, Jia-Qi; Wang, Bing-Xia; Liang, Ren-Xiao;* Jia, Yi-Xia;* Copper-Catalyzed Asymmetric 1,2-Arylboration of Enamines: Access to Chiral Borate-containing 3,3’-Disubstituted Isoindolinones, Organic Biomolecular Chemistry, 2024, 22(30): 6085–6089.
[15] Wang, Bi; Gao, Jing-Kun; Sun, Shuo; Shen, Zhen-Lu; Yang, Yun-Fang; Liang, Ren-Xiao;* Jia, Yi-Xia;* Pd-Catalyzed Asymmetric Intramolecular Dearomatizing Reductive Heck Reaction of Indoles, Organic Letters, 2024, 26(18): 3739–3743.
[14] Gao, Wei-Yang; Yu, Gao-Yang; Li, Yan-Yu; Liang, Ren-Xiao;* Hong, Xin; Jia, Yi-Xia;* Palladium-Catalyzed Dearomative Heck/Suzuki Coupling of C2-Deuterated or C2-Nonsubstituted Indoles, Organic Letters, 2024, 26(12): 2359–2364.
[13] Lu, Jin-Bo; Xu, Xiao-Qiu; Ruan, Zi-Sheng; Liu, Kai; Liang, Ren-Xiao*; Jia, Yi-Xia*; Pd-Catalyzed Intramolecular Dearomative [4+2] Cycloaddition of Naphthalenes with Arylalkynes, Organic Letters, 2023, 25(45): 8139–8144.
[12] Liang, Ren-Xiao*; Tang, Heng-Wei; Liu, Jia-Liang; Xu, Jian-Feng; Chen, Ling-Jia; Jia, Yi-Xia*; Cobalt-Catalyzed Enantioselective Desymmetrizing Reductive Cyclization of Alkynyl Cyclodiketones, Chemical Science, 2023, 14(23): 6393–6398.
[11] Liang, Ren-Xiao; Jia, Yi-Xia*; Aromatic π-Components for Enantioselective Heck Reactions and Heck/Anion-Capture Domino Sequences, Accounts of Chemical Research, 2022, 55(5): 734–745.
[10] Liang, Ren-Xiao*; Chen, Jian-Fei; Huang, Ying-Ying; Yu, Ya-Ping; Zhang, Han-Yue; Song, Yu-Feng; Tsui, Gavin Chit*; Jia, Yi-Xia*; Enantioselective Pd-catalyzed dearomative reductive Heck and domino Heck–Suzuki reactions of 2-CF3-indoles, Chemical Communications, 2022, 58(42): 6200–6203.
[9] Liang, Ren-Xiao; Song, Ling-Jie; Lu, Jin-Bo; Xu, Wei-Yan; Ding, Chao; Jia, Yi-Xia*; Palladium-Catalyzed Enantioselective Heteroarenyne Cycloisomerization Reaction, Angewandte Chemie International Edition, 2021, 60(13): 7412–7417.
[8] Liang, Renxiao; Chen, Kai; Zhang, Qiaohui; Zhang, Jiantao; Jiang, Huanfeng; Zhu, Shifa*; Rapid Access to 2-Methylene Tetrahydrofurans and gamma-Lactones: A Tandem Four-Step Process, Angewandte Chemie International Edition, 2016, 55(7): 2587–2591.
[7] Liang, Ren-Xiao; Zhong, Chao; Liu, Zhi-Hong; Yang, Miao; Tang, Heng-Wei; Chen, Jian-Fei; Yang, Yun-Fang*; Jia, Yi-Xia*; Enantioselective Arylation of Tetrasubstituted Enamines: Access to Enantioenriched Indolenine and 1H-Indole Derivatives, ACS Catalysis, 2021, 11(3): 1827–1832.
[6] Liang, Ren-Xiao; Chen, Ru-Yi; Zhong, Chao; Zhu, Jia-Wen; Cao, Zhong-Yan; Jia, Yi-Xia*; 3,3'-Disubstituted Oxindoles Formation via Copper-Catalyzed Arylboration and Arylsilylation of Alkenes, Organic Letters, 2020, 22(8): 3215–3218.
[5] Liang, Ren-Xiao; Xu, Deng-Yun; Yang, Fu-Ming; Jia, Yi-Xia*; A Pd-Catalyzed Domino Larock Annulation/Dearomative Heck Reaction, Chemical Communications, 2019, 55(53): 7711–7714.
[4] Liang, Ren-Xiao; Wang, Ke; Wu, Quan; Sheng, Wei-Jian; Jia, Yi-Xia*; Palladium-Catalyzed Dearomative Arylvinylation Reaction of Indoles with N‑Arylsulfonylhydrazones, Organometallics, 2019, 38(20): 3927–3930.
[3] Weng, Jian-Quan; Xing, Ling-Ling; Hou, Wen-Ren; Liang, Ren-Xiao*; Jia, Yi-Xia*; Palladium-Catalyzed Dearomative Arylphosphorylation of Indoles, Organic Chemistry Frontiers, 2019, 6(10): 3577–3580.
[2] Liang, Ren-Xiao; Wang, Ke; Song, Ling-Jie; Sheng, Wei-Jian; Jia, Yi-Xia*; Synthesis of Tetracyclic Indolin-3-ones through Pd-Catalyzed Intramolecular Deacetylative Dearomatization of 3-Acetoxy-indoles, RSC Advances, 2019, 9(25):13959–13967.
[1] Liang, Ren-Xiao; Yang, Run-Ze; Liu, Ren-Rong; Jia, Yi-Xia*; Palladium-Catalyzed Asymmetric Dearomative Alkenylation of Indoles through a Reductive-Heck Reaction, Organic Chemistry Frontiers, 2018, 5(11):1840–1843.

[2] 一种含硼吲哚啉酮的制备方法，201911309561.9，2022.7.8
[1] 一种手性吲哚-2,3-并八元碳环化合物的制备方，202011448322.4，2022.11.4

[1] 国家自然科学基金(面上项目)，22371254，2024.01~2027.12，在研，项目负责人
[2] 国家自然科学基金(面上项目)，22071217，2021.01~2024.12，结题，项目负责人
[3] 浙江省自然科学基金(探索项目)，LY22B020008，2022.01~2024.12，结题，项目负责人
[4] 国家自然科学基金(青年项目)，21702184，2018.01~2020.12，结题，项目负责人
[5] 国家自然科学基金(面上项目)，21772175，2018.01~2021.12，结题，项目参与人
[6] 螺环丁烷化合物的合成工艺技术路线开发(企业合作项目)，2025，项目负责人
[7] Paxlovid关键中间体合成工艺路线研究(企业合作项目)，2022，项目负责人
[8] 新型可变色杀菌消毒产品的技术开发(企业合作项目)，2023，项目参与人
[9] 不对称氢化工艺(企业合作项目)，2022，项目参与人
[10] 九洲药业-不对称氢化工艺开发(企业合作项目)，2019，项目参与人

技术咨询