精细化工

基于不对称催化的绿色有机合成、精细化学品合成工艺开发

[1] Wang, Yi-Feng; Wang, Chao-Jie; Feng, Qing-Zhou; Zhai, Jing-Jing; Qi, Suo-Suo; Zhong, Ai-Guo; Chu, Ming-Ming; Xu, Dan-Qian. Copper-catalyzed asymmetric 1,6-conjugate addition of in situ generated para-quinone methides with beta-ketoesters[J]. Chemical Communications, 2022, 58(46): 6653-6656.
[2] Qi, Suo-Suo; Yin, Hao; Wang, Wang, Yi-Feng*, Chao-Jie; Han, Hong-Te; Man, Tong-Tong; Xu, Dan-Qian*. Catalytic Asymmetric Conjugate Addition/Hydroalkoxylation Sequence: Expeditious Access to Enantioenriched Eight-Membered Cyclic Ether Derivatives[J]. Organic Letters, 2021, 23(7): 2471-2476.
[3] Chu, Ming-Ming; Chen, Xue-Yang; Wang, Yi-Feng*; Qi, Suo-Suo; Jiang, Zhen-Hui; Xu, Dan-Qian*; Xu, Zhen-Yuan. Regio- and Enantioselective Friedel-Crafts Benzhydrylation of Indoles in Carbocyclic Ring with ortho-Quinomethanes: Access to Chiral Diarylindolylmethanes[J]. Journal of Organic Chemistry, 2020, 85(15): 9491-9502.
[4] Chu, Ming-Ming; Qi, Suo-Suo; Wang, Wang, Yi-Feng*, Biao; Jiang, Zhen-Hui; Xu, Dan-Qian*; Xu, Zhen-Yuan. Organocatalytic asymmetric 4+1 annulation of in situ generated ortho-quinomethanes with 4-halo pyrazolones: straightforward access to chiral spiro-benzofuran pyrazolones[J]. Organic Chemistry Frontiers, 2019, 6(12): 1977-1982.
[5] Chu, Ming-Ming; Qi, Suo-Suo; Ju, Wan-Zhen; Wang, Yi-Feng*; Chen, Xue-Yang; Xu, Dan-Qian*; Xu, Zhen-Yuan. Asymmetric organocatalytic conjugated addition of pyrazolin-5-ones to ortho-quinomethanes: construction of vicinal tertiary and all-carbon quaternary stereocenters[J]. Organic Chemistry Frontiers, 2019, 6(8): 1140-1145.
[6] Wang, Yi-Feng; Shao, Juan-Juan; Wang, Biao; Chu, Ming-Ming; Qi, Suo-Suo; Du, Xiao-Hua; Xu, Dan-Qian*. Asymmetric Brominative Dearomatization of Naphthols Catalyzed by Chiral Copper Complexes[J]. Advanced Synthesis & Catalysis, 2018, 360(12): 2285-2290.
[7] Wang, Yifeng; Zhang, Cheng; Wang, Haojiang; Jiang, Yidong; Du, Xiaohua; Xu, Danqian*. Bifunctional Amine-Squaramide Catalyzed Friedel-Crafts Alkylation Based on ortho-Quinone Methides in Oil-Water Phases: Enantioselective Synthesis of Triarylmethanes[J]. Advanced Synthesis & Catalysis, 2017, 359(5): 791-797.
[8] Wang, Yifeng; Chu, Mingming; Zhang, Cheng; Shao, Juanjuan; Qi, Suosuo; Wang, Biao; Du, Xiaohua; Xu, Danqian*. Asymmetric Organocatalytic Conjugate Addition of Thiocarboxylic Acids to In Situ-Generated ortho-Quinomethanes in Oil-Water Phases[J]. Advanced Synthesis & Catalysis, 2017, 359(23): 4170-4176.
[9] Wang, Yifeng; Wang, Haojiang; Jiang, Yidong; Zhang, Cheng; Shao, Juanjuan; Xu, Danqian*. Fast, solvent-free and highly enantioselective fluorination of beta-keto esters catalyzed by chiral copper complexes in a ball mill[J]. Green Chemistry, 2017, 19(7): 1674-1677.
[10] Wang, Yi-Feng; Chen, Ru-Xiang; Wang, Ke; Zhang, Bin-Bin; Li, Zhao-Bo; Xu, Dan-Qian*. Fast, solvent-free and hydrogen-bonding-mediated asymmetric Michael addition in a ball mill[J]. Green Chemistry, 2012, 14(4): 893-895.

主持：
1、国家自然科学基金，基于两相体系的有机不对称催化串联反应研究
2、浙江省重点研发计划课题，生态安全高效生物防治制剂研发-基于春雷霉素-噻唑锌新型生物制剂的研发及产业化
3、浙江省自然科学基金，新型氢键催化剂的设计合成及其不对称催化性能研究
4、重大横向（到款110万），高效低毒杀菌剂合成技术
5、重大横向（合同金额100万，到款60万），绿色高效除草剂合成技术
参与：
1、国家重点研发计划课题（2/10），高效农药与中间体绿色制备技术
2、重大横向项目（到款1010万，2/6），绿色农药及中间体清洁生产技术研发
3、重大横向项目（合同金额1010万，已到款200万，2/6）,农药及专用中间体绿色制备技术