精细化工

1. 手性合成与不对称催化
2. 药物及中间体合成及工艺
3. 精细化工与绿色化学

Asymmetric Catalysis;Palladium;Arylation;Oxindoles;Heterocycles;Nickel;Dearomatization;N-heterocyclic Carbenes;Ketoamide;Homogenous Catalysis

1.Duan, Xinyu; Cui, Dong; Wang, Zhiguo; Zheng, Dannan; Jiang, Linye; Huang, Wen-Yu; Jia, Yi-Xia*; Xu Jian*. A Photoenzymatic Strategy for Radical-Mediated Stereoselective Hydroalkylation with Diazo Compounds, Angew. Chem. Int. Ed. 2023 e202214135.
2.Liang, Ren-Xiao; Jia, Yi-Xia*. Aromatic π-components for enantioselective Heck reactions and Heck/anion-capture domino sequences, Acc. Chem. Res. 2022, 55, 734.
3.Yang, Peng; Wang, Qiang; Cui, Bing-Hui; Zhang, Xiao-Dong; Liu, Hang; Zhang, Yue-Yuan; Liu, Jia-Liang; Huang, Wen-Yu; Liang, Ren-Xiao; Jia, Yi-Xia*. Enantioselective dearomative [3+2] umpolung annulation of N-heteroarenes with alkynes, J. Am. Chem. Soc. 2022, 144, 1087.
4.Liang, Ren-Xiao; Song, Ling-Jie; Lu, Jin-Bo; Xu, Wei-Yan; Ding, Chao; Jia, Yi-Xia*. Palladium-catalyzed enantioselective heteroarenyne cycloisomerization reaction, Angew. Chem. Int. Ed. 2021, 60, 7412.
5.Zhou, Bo; Wang, Hongliang; Cao, Zhong-Yan; Zhu, Jia-Wen; Liang, Ren-Xiao; Hong, Xin*; Jia, Yi-Xia*. Dearomative 1,4-difunctionalization of naphthalenes via palladium-catalyzed tandem Heck/Suzuki coupling reaction, Nat. Commun. 2020, 11, 4380.
6.Li, Xiang; Zhou, Bo; Yang, Run-Ze; Yang, Fu-Ming; Liang, Ren-Xiao; Liu, Ren-Rong; Jia, Yi-Xia*. Palladium-catalyzed enantioselective intramolecular dearomative Heck reaction, J. Am. Chem. Soc. 2018, 140, 13954.
7.Liu, Ren-Rong; Wang, Yong-Gang; Li, Ying-Long; Huang, Bing-Bing; Liang, Ren-Xiao; Jia, Yi-Xia*. Enantioselective dearomative difunctionalization of indoles by Palladium-catalyzed Heck/Sonogashira sequence, Angew. Chem. Int. Ed. 2017, 56, 7475.
8.Liu, Ren-Rong; Li, Bao-Le; Lu, Jun; Shen, Chong; Gao, Jian-Rong; Jia, Yi-Xia*. Palladium/L-Proline-catalyzed enantioselective α-arylative desymmetrization of cyclohexanones, J. Am. Chem. Soc. 2016, 138, 5198.
9.Liu, Ren-Rong; Ye, Shi-Chun; Lu, Chuan-Jun; Zhuang, Gui-Lin; Gao, Jian-Rong; Jia, Yi-Xia*. Dual catalysis for the redox annulation of nitroalkynes with indoles: enantioselective construction of indolin-3-ones bearing quaternary stereocenters, Angew. Chem. Int. Ed. 2015, 54, 11205.
10.Shen, Chong; Liu, Ren-Rong; Fan, Ren-Jie; Li, Ying-Long; Xu, Teng-Fei; Gao, Jian-Rong; Jia, Yi-Xia*. Enantioselective arylative dearomatization of indoles via Pd-catalyzed intramolecular reductive Heck reactions, J. Am. Chem. Soc. 2015, 137, 4936.

1、贾义霞，罗杰琼，刘凯，宋钰锋，一种N-酰基-2-烷基吲哚啉化合物的制备方法, 专利号：ZL202210127474.7
2、贾义霞，陈如意，梁仁校，一种含硼吲哚啉酮衍生物的制备方法，专利号：ZL201911309561.9
3、贾义霞，张禹，钟超，梁仁校，一种手性吲哚-2,3-并八元碳环化合物的制备方法，专利号：ZL202011448322.4

1、国家自然科学基金面上项目：钯催化缺电子氮杂芳烃的不对称去芳构化环化-重排串联反应(22371255)，2024.1-2027.12，50万元，主持
2、国家自然科学基金重大研究计划培育项目：阻断C-H键活化的不对称去芳构化Heck反应及串联反应研究(91956117)，2020.1-2022.12，75万元，主持
3、国家自然科学基金面上项目：钯/手性胺共催化环酮不对称芳基化反应研究(21772175)，2018.1-2021.12，66万元，主持
4、国家自然科学基金优青项目：不对称催化与手性合成(21522207)，2016.1-2018.12，130万元，主持
5、国家自然科学基金面上项目：构建三氟甲基取代的全碳型季碳手性中心的催化不对称共轭加成反应研究(21372202)，2014.1-2017.12，80万元，主持
6、国家自然科学基金青年项目：过渡金属催化的芳基卤化物为亲核试剂的反应及其不对称催化研究(21002089)，2011.1-2013.12，19万元，主持
7. 浙江省自然科学基金重点项目：构建叔碳手性中心的不对称去芳构化串联反应(LZ23B020006)，2023.1-2025.12，30万元，主持
8、浙江省自然科学基金杰青项目：新型催化不对称傅克反应研究(LR14B020001)，2014.1-2017.12，30万元，主持
9、教育部新世纪优秀人才支持计划项目：基于离子中间体手性控制的不对称傅克反应研究(NCET-12-1086)，2013.1-2015.12，50万元，主持

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