天然气化工,新材料,石油炼制,石油化工,精细化工,生物医药

有机合成方法学，天然产物（生物碱，信息素等）及药物的不对称合成，多样性导向合成，化学生物学。

Asymmetric Synthesis;Alkaloids;Total Synthesis;Synthetic Methods;Amides;Amide Activation;Enantioselective Synthesis;Natural Products;Reductive Alkylation;Chemoselective Synthesis

1. Chen-Xi Ye, Yared Yohannes Melcamu, Heng-Hui Li, Jiang-Tao Cheng, Tian-Tian Zhang, Yuan-Ping Ruan, Xiao Zheng,* Xin Lu,* and Pei-Qiang Huang,* Dual Catalysis for Enantioselective Convergent Synthesis of Enantiopure Vicinal Amino Alcohols, Nature Commun. 2018, 9:410.

2. Pei-Qiang Huang,* and Hui Geng, Ni-Catalyzed Chemoselective Alcoholysis of N-Acyloxazolidinones, Green Chem. 2018, 20, 593-599.

3. Pei-Qiang Huang* and Hang Chen, Ni-Catalyzed Cross-Coupling Reactions of N-Acylpyrrole-Type Amides with Organoboron Reagents, Chem. Commun. 2017, 53, 12584 – 12587.

4. Huang, Pei-Qiang; Huang, Ying-Hong; Geng, Hui; Ye, Jian-Liang. Metal-Free C-H Alkyliminylation and Acylation of Alkenes with Secondary Amides. Sci. Rep. 2016, 6, 28801.

5. Guo, Lian-Dong; Huang, Xiong-Zhi; Luo, Shi-Peng; Cao, Wen-Sen; Ruan, Yuan-Ping; Ye, Jian-Liang; Huang, Pei-Qiang. Organocatalytic, Asymmetric Total Synthesis of (-)-Haliclonin A. Angew. Chem., Int. Ed. 2016, 55, 4064-4068.

6. Zheng, Xiao; He, Jiang; Li, Heng-Hui; Wang, Ao; Dai, Xi-Jie; Wang, Ai-E; Huang, Pei-Qiang. Titanocene(III)-Catalyzed Three-Component Reaction of Secondary Amides, Aldehydes, and Electrophilic Alkenes. Angew. Chem., Int. Ed. 2015, 54, 13739-13742.

7. Zheng, Xiao; Dai, Xi-Jie; Yuan, Hong-Qiu; Ye, Chen-Xi; Ma, Jie; Huang, Pei-Qiang. Umpolung of Hemiaminals: Titanocene-Catalyzed Dehydroxylative Radical Coupling Reactions with Activated Alkenes. Angew. Chem., Int. Ed. 2013, 52, 3494-3498.

8. Xiao, Kai-Jiong; Wang, Ai-E; Huang, Pei-Qiang. Direct Transformation of Secondary Amides into Secondary Amines: Triflic Anhydride Activated Reductive Alkylation. Angew. Chem., Int. Ed. 2012, 51, 8314-8317.

9. Xiao, Kai-Jiong; Luo, Jie-Min; Ye, Ke-Yin; Wang, Yu; Huang, Pei-Qiang. Direct, One-pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents through Lactam/Amide Activation. Angew. Chem., Int. Ed. 2010, 49, 3037-3040.

10. Wang, Wei-jia; Hou, Pei-pei; Li, Feng-wei; Zhou, Bo; Chen, Hang-zi; Bian, Xue-li; Cai, Qi-xu; Xing, Yong-zhen; He, Jian-ping; Zhang, Hongkui; Huang, Pei-qiang; Lin, Tianwei; Wu, Qiao. Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity. Chem. Biol. 2015, 22, 1040-1051.

11. Li, Li; Liu, Yuan; Chen, Hang-zi; Li, Feng-wei; Wu, Jian-feng; Zhang, Hong-kui; He, Jian-ping; Xing, Yong-zhen; Chen, Yan; Wang, Wei-jia; Tian, Xu-yang; Li, An-zhong; Zhang, Qian; Huang, Pei-qiang; Han, Jiahuai; Lin, Tianwei; Wu, Qiao. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat. Chem. Biol. 2015, 11, 339-346.

12. Wang, Wei-jia; Wang, Yuan; Chen, Hang-zi; Xing, Yong-zhen; Li, Feng-wei; Zhang, Qian; Zhou, Bo; Zhang, Hong-kui; Zhang, Jie; Bian, Xue-li; Li, Li; Liu, Yuan; Zhao, Bi-xing; Chen, Yan; Wu, Rong; Li, An-zhong; Yao, Lu-ming; Chen, Ping; Zhang, Yi; Tian, Xu-yang; Beermann, Friedrich; Wu, Mian; Han, Jiahuai; Huang, Pei-qiang; Lin, Tianwei; Wu, Qiao. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat. Chem. Biol. 2014, 10, 133-140.

13. Zhan, Yan-yan; Chen, Yan; Zhang, Qian; Zhuang, Jia-jia; Tian, Min; Chen, Hang-zi; Zhang, Lian-ru; Zhang, Hong-kui; He, Jian-ping; Wang, Wei-jia; Wu, Rong; Wang, Yuan; Shi, Chunfang; Yang, Kai; Li, An-zhong; Xin, Yong-zhen; Li, Terytty Yang; Yang, James Y.; Zheng, Zhong-hui; Yu, Chun-dong; Lin, Sheng-Cai; Chang, Chawnshang; Huang, Pei-qiang; Lin, Tianwei; Wu, Qiao. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat. Chem. Biol. 2012, 8, 897-904.

14. Liu, Jing-jing; Zeng, Hui-ni; Zhang, Lian-ru; Zhan, Yan-yan; Chen, Yan; Wang, Yuan; Wang, Juan; Xiang, Shao-hua; Liu, Wen-jun; Wang, Wei-jia; Chen, Hang-zi; Shen, Yue-mao; Su, Wen-jin; Huang, Pei-qiang; Zhang, Hong-kui; Wu, Qiao. A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro. Cancer Res. 2010, 70, 3628-3637.

15. Chen, Liqun; Wang, Zhi-Gang; Aleshin, Alexander E.; Chen, Fan; Chen, Jiebo; Jiang, Fuquan; Alitongbieke, Gulimiran; Zeng, Zhiping; Ma, Yue; Huang, Mingfeng; Zhou, Hu; Cadwell, Gregory; Zheng, Jian-Feng; Huang, Pei-Qiang; Liddington, Robert C.; Zhang, Xiao-kun; Su, Ying. Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem. Biol. 2014, 21, 596-607.

1. 由酰胺经铱和硼试剂共同催化硅氢化合成胺类化合物的制备方法
厦门大学
黄培强; 韩丰
公开日期: 2022-03-15 申请日期: 2020-09-15 公开号: CN114181090A

2. Methods and compositions related to retinoid receptor-selective pathway
UNIV XIAMEN; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INST
ZHANG XIAO-KUN; SU YING; ZHOU HU; LIU WEN; HUANG PEI-QIANG
公开日期: 2018-10-02 申请日期: 2017-02-16 公开号: US10087156B2

3. Inducing apoptosis in a cancer cell, comprises upregulating TNF alpha activity in a cancer cell to sensitize the cancer cell to the suppression of protein kinase B and contacting sensitized cancer cell with a compound.
ZHANG X; SU Y; ZHOU H; LIU W; HUANG P; HUANG P C; JANG S K; SU; ZHANG X K; HUANG P Q
公开日期: 2018-08-20 申请日期: 2011-05-06 公开号: KR1889290B1

4. Inducing apoptosis in a cancer cell, comprises upregulating TNF alpha activity in a cancer cell to sensitize the cancer cell to the suppression of protein kinase B and contacting sensitized cancer cell with a compound.
ZHANG X; LIU W; JANG S K; SU Y; HUANG P; SU; HUANG P Q; ZHOU H; HUANG P C; ZHANG X K
公开日期: 2018-08-15 申请日期: 2016-07-04 公开号: JP6375340B2

5. METHODS AND COMPOSITIONS RELATED TO RETINOID RECEPTOR-SELECTIVE PATHWAY
SANFORD-BURNHAM MEDICAL RES INST; UNIV XIAMEN
ZHANG XIAO-KUN; SU YING; ZHOU HU; LIU WEN; HUANG PEI-QIANG
公开日期: 2017-11-02 申请日期: 2017-02-16 公开号: US2017313668A1

6. 涉及类视黄醇受体选择性通路的方法和组合物
SANFORD-BURNHAM MEDICAL RES INSTITUTE; UNIV XIAMEN
XIAO-KUN ZHANG; YING SU; HU ZHOU; WEN LIU; PEI-QIANG HUANG
公开日期: 2017-08-18 申请日期: 2011-05-06 公开号: CN107050007A

7. 种合成α,β不饱和酰胺化合物的方法
UNIV XIAMEN
HUANG PEIQIANG; ZHENG JIANFENG; HU XIUNING; CAI DONGCHENG; SHEN TAILONG
公开日期: 2017-05-31 申请日期: 2017-01-13 公开号: CN106748949A

8. Methods and compositions related to a retinoid receptor-selective pathway
Xiao-kun Zhang; Hu Zhou; Wen Liu; Ying Su; Pei-Qiang Huang
Ying Su; Wen Liu; Xiao-kun Zhang; Hu Zhou; Pei-Qiang Huang
公开日期: 2017-04-04 申请日期: 2011-05-06 公开号: US09611235B2

9. Methods and compositions related to a retinoid receptor-selective pathway
ZHANG XIAO-KUN; SANFORD-BURNHAM MEDICAL RES INST; SU YING; UNIV XIAMEN; ZHOU HU; LIU WEN; HUANG PEI-QIANG
ZHANG XIAO-KUN; SU YING; ZHOU HU; LIU WEN; HUANG PEI-QIANG
公开日期: 2017-04-04 申请日期: 2011-05-06 公开号: US9611235B2

10. METHOD AND COMPOSITION RELATING PATHWAY SELECTIVE FOR RETINOID RECEPTOR
SANFORD-BURNHAM MEDICAL RES INST; UNIV XIAMEN
ZHANG XIAO-KUN; SU YING; HU ZHOU; LIU WEN; HUANG PEI-QIANG
公开日期: 2017-01-12 申请日期: 2016-07-04 公开号: JP2017008050A

11. 2-[3,5-二羟基-2-(1-酰基)苯基]乙酸酯的应用
厦门大学
张洪奎; 林天伟; 刘元; 吴乔; 黄培强; 李莉; 陈航姿
公开日期: 2016-01-20 申请日期: 2014-02-08 公开号: CN103751160B

12. METHODS AND COMPOSITIONS RELATED TO A RETINOID RECEPTOR-SELECTIVE PATHWAY
ZHANG XIAO-KUN; SU YING; ZHOU HU; LIU WEN; HUANG PEI-QIANG
ZHANG XIAO-KUN; SU YING; ZHOU HU; LIU WEN; HUANG PEI-QIANG
公开日期: 2015-09-24 申请日期: 2011-05-06 公开号: US2015266842A1

13. 一种1-(3,4,5-三羟基)苯基-1-烷基酮的制备方法
厦门大学
张洪奎; 黄培强; 张洁
公开日期: 2015-08-19 申请日期: 2012-09-18 公开号: CN102826985B

14. 一种喹诺里西啶酮化合物的合成方法
厦门大学
郑剑峰; 谢志强; 黄培强
公开日期: 2015-04-22 申请日期: 2015-01-26 公开号: CN104530041A

15. 一种喹诺里西啶酮化合物的合成方法
厦门大学
郑剑峰; 谢志强; 黄培强
公开日期: 2015-04-22 申请日期: 2015-01-26 公开号: CN104530041A

16. Methods and compositions related to a retinoid receptor-selective pathway
UNIV XIAMEN; SANFORD BURNHAM MED RES INST
ZHANG XIAO-KUN; ZHOU HU; HUANG PEI-QIANG; SU YING; LIU WEN
公开日期: 2015-03-12 申请日期: 2011-05-06 公开号: AU2011249857B2

17. 一种舞毒蛾性信息素的合成方法
厦门大学
黄培强; 王志刚; 郑剑峰
公开日期: 2014-08-13 申请日期: 2011-06-02 公开号: CN102321050B

18. 2-[3,5-二羟基-2-(1-酰基)苯基]乙酸酯的应用
厦门大学
张洪奎; 林天伟; 刘元; 吴乔; 黄培强; 李莉; 陈航姿
公开日期: 2014-04-30 申请日期: 2014-02-08 公开号: CN103751160A

19. Organic/inorganic hybrid composite proton exchange membrane comprises inorganic material having specific surface area; and organic material comprising sulfonated polymer or phosphoric acid doped polymer.
TSAI L; LIAO Y; CHEN S; LIN J; LAI C; HUANG C; CHANG S; CAI L D; LIAO Y H; CHEN S W; LIN J N; LAI J M; HUANG Q P; ZHANG S J; TSAI L D
公开日期: 2014-01-11 申请日期: 2009-12-31 公开号: TW423511B1

20. Inducing apoptosis in a cancer cell, comprises upregulating TNF alpha activity in a cancer cell to sensitize the cancer cell to the suppression of protein kinase B and contacting sensitized cancer cell with a compound.
SU Y; LIU W; JANG S K; ZHANG X K; ZHANG X; ZHOU H; HUANG P; HUANG P C; SU; HUANG P Q
公开日期: 2013-12-27 申请日期: 2013-09-24 公开号: HK1183442A0

1. 第17届国际磷化学大会
立项时间: 2007-2007 项目经费：90000

2. 重要生理活性天然产物的结构多样性合成研究
立项时间: 2009-2012 项目经费：2400000

3. 第六届全国化学生物学学术会议
立项时间: 2009-2009 项目经费：40000

4. 复杂生物碱Sarain A和甲氧代百部叶碱的对映选择性全合成研究
立项时间: 2017-2020 项目经费：680000

5. 第六届亚洲有机化学前沿国际研讨会会前会即第一届亚洲核心计划青年学术会议
立项时间: 2011-2011 项目经费：70000

6. 第十三届国际华人有机化学研讨会暨第十届国际华人无机化学研讨会
立项时间: 2014-2014 项目经费：60000

7. 步骤经济型反应及其应用研究
立项时间: 2014-2018 项目经费：3000000

8. Lactacystin及相关r--内酰胺的不对称合成研究
立项时间: 2001-2003 项目经费：170000

9. 特特拉姆酸类天然产物的不对称合成研究
立项时间: 2006-2008 项目经费：400000

10. 海洋天然产物Haliclonin A的有机催化不对称全合成研究
立项时间: 2015-2018 项目经费：980000

11. 参加4th HOPE Meeting会议
立项时间: 2012-2012 项目经费：8000

12. 含吡咯烷环多羟基化合物的不对称合成研究
立项时间: 1996-1998 项目经费：80000

13. 第二届中日青年有机化学家研讨会
立项时间: 2003-2003 项目经费：7000

14. 2008化学生物学学术研讨会
立项时间: 2008-2008 项目经费：10000

15. 第八届国际华人有机化学研讨会暨第五届国际华人无机化学研讨会
立项时间: 2004-2004 项目经费：6000

16. 第二届中法（里昂）化学研讨会
立项时间: 2007-2007 项目经费：70000

17. 小分子的识别与选择性反应
立项时间: 1999-2002 项目经费：800000

18. 第七届碳负离子化学国际学术研讨会
立项时间: 2004-2005 项目经费：25000

19. 第四届中－韩有机化学讨论会
立项时间: 2006-2006 项目经费：4000

20. 合办“第八届化学前沿学科青年学者研讨会”
立项时间: 2002-2003 项目经费：30000

21. 中法先进化学与应用学术研讨会
立项时间: 2004-2004 项目经费：40000

22. 基于新合成方法的托品类和哌啶酮生物碱的不对称全合成研究
立项时间: 2011-2013 项目经费：360000

23. 高生理活性吡咯烷生物碱的不对称合成
立项时间: 1992-1994 项目经费：50000

24. 第13届有机合成会议
立项时间: 2000-2000 项目经费：9000

25. 生理活性哌啶生物碱的不对称合成研究
立项时间: 2003-2005 项目经费：300000

26. 生物启发的百部生物碱的对映选择性多样性全合成研究
立项时间: 2020

27. 含氮化合物高效高选择性合成方法学及其应用
立项时间: 2020-2024

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