天然气化工,新材料,石油炼制,石油化工,精细化工,生物医药

晶体功能材料，复合荧光探针等

合成;α-肾上腺素受体拮抗剂;良性前列腺增生;坦索罗辛

Fluorescent Probe;CU2+;Hydrazone;Cell Imaging;Viscosity;Coumarin;Pyrrole;Ratiometric Fluorescent Probe;H2S;Lysosome-targetting

1.Si-Lin Xu1, Fang-Fang Guo1, Zhi-Hong Xu*, Yuan Wang*, Tony D. James*, A hemicyanine-based fluorescent probe for ratiometric detection of ClO- and turn-on detection of viscosity and its imaging application in mitochondria of living cells and zebrafish, Sensors and Actuators B: Chemical 383 (2023) 133510.
2.Wei-Na Wu1,*, Yu-Fei Song1, Xiao-Lei Zhao, Yuan Wang*, Yun-Chang Fan, Zhi-Hong Xu*, Tony D. James*, Multifunctional 1,3-benzoxazole-merocyanine-based probe for the ratiometric fluorescence detection of pH/HSO3-/viscosity in mitochondria, Chemical Engineering Journal 464 (2023) 142553.
3.Shuang-Shuang Liu1, Wei-Na Wu1,*, Xiao-Lei Zhao, Yun-Chang Fan, Yuan Wang*, Zhi-Hong Xu*, A dual-emission fluorescence probe for the detection of viscosity and hydrazine in environmental and biological samples, Analytica Chimica Acta, 1245 (2023) 340867.
4.Ling Zhang, Wei-Na Wu*, Xiao-Lei Zhao, Yun-Chang Fan, Yuan Wang*, Zhi-Hong Xu*, A coumarin/cyanoacetamide-derived lysosome-targeting probe for detecting bisulfite and viscosity changes in living cells and zebrafish, Dyes and Pigments 208 (2022) 110862
5.Pan Liu, Wei-Na Wu*, Yuan Wang *, Yun-Chang Fan a, Zhi-Hong Xu*, A dual-ratiometric mitochondria-targeted fluorescent probe to detect hydrazine in soil samples and biological imaging, Journal of Hazardous Materials 440 (2022) 129713
6.Fang-Fang Guo1, Wei-Na Wu1, Xiao-Lei Zhao, Yuan Wang*, Yun-Chang Fan, Chuan-Xiang Zhang*, Zhi-Hong Xu*, A water-soluble lysosome-targetable fluorescent probe for carboxylesterase detection and its application in biological imaging, Dyes and Pigments 199 (2022) 110079
7.Yuan Wang1, Yu-Fei Song1, Ling Zhang, Geng-Geng Dai, Rui-Fang Kang, Wei-Na Wu∗, Zhi-Hong Xu∗∗, Yun-Chang Fan, Lin-Yan Bian, A pyrazole-containing hydrazone for fluorescent imaging of Al3+ in lysosomes and its resultant Al3+ complex as a sensor for F−, Talanta 203 (2019) 178–185
8.Yuan Wang, Hao Wu, Wei-Na Wu,∗, Shou-Jie Li, Zhi-Hong Xu,∗, Zhou-Qing Xu, Yun-Chang Fan, Xiao-Lei Zhao, Bao-Zhong Liu,∗ An AIRE active Schiff base bearing coumarin and pyrrole unit: Cu2+detection in either solution or aggregation states, Sensors and Actuators B: Chemical 260 (2018) 106–115
9.Wei-Na Wu, Pan-Dong Mao, Yuan Wang,∗, Xian-Jie Mao, Zhou-Qing Xu, Zhi-Hong Xu,∗, Xiao-Lei Zhao,∗, Yun-Chang Fan, Xu-Feng Hou, AEE active Schiff base-bearing pyrene unit and further Cu2+–inducedself-assembly process, Sensors and Actuators B: Chemical 258 (2018) 393–401
10.Yuan Wang, Pan-Dong Mao, Wei-Na Wu*, Xian-Jie Mao, Yun-Chang Fan, Xiao-Lei Zhao*, Zhou-Qing Xu, Zhi-Hong Xu*, New pyrrole-based single-molecule multianalyte sensor for Cu2+, Zn2+, and Hg2+ and its AIE activity, Sensors and Actuators B: Chemical, 255 (2018) 3085–3092
11.Yuan Wang, Pan-Dong Mao, Wei-Na Wu*, Xian-Jie Mao, Xiao-Lei Zhao*, Zhou-Qing Xu, Yun-Chang Fan, Zhi-Hong Xu*, A novel colorimetric and ratiometric fluorescent Cu2+ sensor based on hydrazone bearing 1,8-naphthalimide and pyrrole moieties, Sensors and Actuators B: Chemical 251 (2017) 813–820
12.Yuan Wang, Hui-Qin Chang, Wei-Na Wu*, Xiao-Lei Zhao, Yong Yang, Zhou-Qing Xu*, Zhi-Hong Xu*, Lei Jia, Rhodamine-2-thioxoquinazolin-4-one conjugate: A highly sensitiveand selective chemosensor for Fe3+ ions and crystal structures of its Ag(I) and Hg(II) complexes, Sensors and Actuators B: Chemical 239 (2017) 60–68
13.Yuan Wang, Hui-Qin Chang, Wei-Na Wu*, Wen-Bing Peng, Yong-Fei Yan,Chun-Ming He, Ting-Ting Chen, Xiao-Lei Zhao*, Zhou-Qing Xu*, Rhodamine 6G hydrazone bearing pyrrole unit: Ratiometric andselective fluorescent sensor for Cu2+ based on two different approaches, Sensors and Actuators B: Chemical 228 (2016) 395-400.
著作
1.王元等，化学反应原理及反应器研究，化学工业出版社，2013
2.王元，《分析化学中的典型分析方法及新进展研究》（独著），中国原子能出版社，2018

1.王元，吴伟娜，李慧军，闫玲玲，吴浩，一种基于吡咯香豆素双腙衍生物的荧光探针及其制备方法与应用，国家发明专利，2017105431905，2020.4.7.
2.王元，吴伟娜，蔡红新，陈亮，吴浩，一种邻香兰素衍生物及其制备方法和应用，国家发明专利，2017105901046，2020.4.17.
3.王元，吴伟娜，赵晓雷，王碗碗，萘并吡喃卡巴腙衍生物及其制备方法和应用，国家发明专利，2018102465976，2020.5.5.
4.王元，吴伟娜，于亚平，李姗姗，寇凯，刘树阳，赵玲玲，基于吡嗪联吡唑酰腙衍生物的荧光探针及其制备方法和应用，2017106124088，国家发明专利， 2020.7.28.
5.王元，吴伟娜，李慧军，吴浩，基于吡啶联吡唑酰腙衍生物的荧光探针及其制备方法和应用，2017106139793，国家发明专利， 2020.10.2.
6.王元，吴伟娜，赵晓雷，郭芳芳，李晓红，刘盼，一种吡咯-部花菁衍生物荧光探针及其制备方法和应用，2019111560512，国家发明专利， 2020.11.13.
7.王元，吴伟娜，赵晓雷，李晓红，刘盼，郭芳芳，一种吡咯双腙衍生物荧光探针及其制备方法和应用， 2019111560438，国家发明专利， 2021.02.05.
8.王元，吴伟娜，李慧军，吴浩，王碗碗，香豆素硫代卡巴腙衍生物及其制备方法和应用，2018101258926，国家发明专利，2021.4.30.
9.王元，吴伟娜，王贝贝，薛文招，吕目轩，一种基于苯并吡喃腈衍生物的荧光探针及其制备方法和应用，2018112483379，国家发明专利，2021.02.02
10.王元，吴伟娜，赵晓雷，宗海涛，吕目轩，高亮亮，一种含香豆素的氨基吡嗪酰腙衍生物的荧光探针及其制备方法和应用，2019101587769，国家发明专利，2022.09.30

1.国家自然科学基金项目，胍基修饰的吡咯席夫碱铜（II）配合物超氧化物歧化酶的模拟研究（21001040），主持，2011.1-2013.12
2.河南省科技厅科技攻关项目，基于纳米MOFs固定化酶3-羟基丁酸试剂盒的研发（212102210033），主持，2021.1-2012.12
3.河南省自然科学基金面上项目，多酸为载体的水溶性有机-无机杂化荧光探针的制备及生物成像应用（182300410183），主持，2018.1-2020.4
4.河南省科技厅基础与前沿研究项目，Mo36多酸基有机-无机杂化材料光敏特性的研究（162300410011），主持，2016.6-2019.7
5.河南省人力与社会保障厅留学人员科技活动项目择优资助项目，AIE/POMs“触发式”溶酶体pH 探针对癌细胞的长效超灵敏荧光示踪，主持，2023.1-2023.12
6.河南理工大学安全学科“双一流”创建工程项目，MOFs基超灵敏光气荧光探针的构建（AQ20230745），主持，2023.1-2025.12
7.河南省高等学校青年骨干教师，不同间隔臂长系列胍基修饰的吡咯席夫碱铜配合物超氧化物歧化酶的模拟研究（2014GGJS-045），主持，2015.1-2017.12

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