精细化工

金属有机化学反应、有机烯烃高分子功能材料、烯烃和芳香族化合物的绿色催化合成

Nickel;N-heterocyclic Carbenes;Hydroalkenylation;Asymmetric Catalysis;Olefins;Asymmetric Epoxidation;Heterocycles;Oxidative Coupling;Nickel-catalyzed;Insertion

（20）(NHC)NiH-Catalyzed Regiodivergent Cross-Hydroalkenylation of Vinyl Ether with α-Olefin: 1,2- and 1,3-Disubstituted Allyl Ether Syntheses. Chen, W.; Li, Y.; Chen, Y.; Ho, C.-Y.* Angew. Chem. Int. Ed. 2018, 57, 2677. (Highlighted in X-mol & Chin. J. Org.Chem.)

（19）(NHC)NiH-Catalyzed Intermolecular Regio- and Diastereoselective Cross-Hydroalkenylation of Endocyclic Dienes with α-Olefins. Lian, X.; Chen, W.; Dang, L.; Li, Y.; Ho, C.-Y.* Angew. Chem. Int. Ed. 2017, 56, 9048. (Highlighted in X-mol.)

（18）Mechanism and Regioselectivities of (NHC)Nickel(II)hydride-Catalyzed Cycloisomerization of Dienes: A Computational Study. Gao, Y.; Houk, K. N.; Ho, C.-Y.*; Hong, X.* Org. Biomol. Chem. 2017, 15, 7131. Themed Collections: Mechanistic Aspects of Organic Synthesis

（17）Catalytic Asymmetric Hydroalkenylation of Vinylarenes: Electronic Effects of Substrates and Chiral N-Heterocyclic Carbene Ligands Ho, C.-Y.*; Chan, C.-W.; He, L. Angew. Chem. Int. Ed. 2015, 54, 4512.
Featured as Front Cover & VIP (Very Important Paper),
in Angew. Chem. Int. Ed. 2015, 54 (15), 4403.
in ChemCatChem 2015, 7, 1639 by Prof. Gerhard Hilt &
in ChemInform (preparative org. chem.) & in X-Mol.

（16）Substituted 1,3-cyclohexadiene synthesis by NHC-Nickel(0) catalyzed [2+2+2] cycloaddition of 1,n-Enyne”. Zhao, J.-P.; Chan, S.-C.; Ho, C.-Y.* Tetrahedron 2015, 71, 4426. Invited Special Symposium-in-Print: Progress in organic synthesis: New reactions, strategies and targets.

（15）Computational Exploration of Mechanism and Selectivities of NHC-Ni(II)hydride Catalyzed Hydroalkenylations of Styrene with a-Olefins. Hong, X.; Wang, J.; Yang, Y.-F.; He, L.; Ho, C.-Y.*; Houk, K. N.* ACS Catal. 2015, 5, 5545.

（14）Nitrate-Enhanced NHC-NiH Catalyzed Tail-to-Tail Vinyl Ether Dimerization. He, L.; Ho, C.-Y.* Synlett 2014, 25, 2738. (Invited Special Issue: Catalysis with Sustainable Metals.)

（13）Medium-Sized Heterocycle Synthesis by the Use of Synergistic Effects of Ni-NHC and γ Coordination in Cycloisomerization. Ho, C.-Y.*; He, L. J. Org. Chem. 2014, 79, 11873.
Highlighted thrice:
in SynFacts 2014, 10, 913 (by Prof. V. Snieckus)
in ChemInform (preparative org. chem.)
in Organic Chemistry Highlights, 2015(by Prof. D. F. Taber)“C-O Ring Construction”

（12）Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as acetylcholinesterase inhibitors. Qian, S.; He, L.; Mak, M.; Han, Y.*; Ho, C.-Y.*; Zuo, Z.* Int. J. Pharmaceutics, 2014, 477, 442.

（11）Shuffle off the Classic b-Si Elimination by Ni-NHC Cooperation: Implication for C-C Forming Reactions Involving Ni-Alkyl-β-Silanes. Ho, C.-Y.*; He, L. Chem. Commun. 2012, 48, 1481.
Highlighted twice:
in Novo Nordisk & in ChemInform (Organoelement compounds)

（10）Catalytic Intermolecular Tail-to-Tail Hydroalkenylation of Styrenes with alpha Olefins: Regioselective Migratory Insertion Controlled by a Nickel/N-Heterocyclic Carbene. Ho, C.-Y.*; He, L. Angew. Chem. Int. Ed. 2010, 49, 9182.
Highlighted thrice:
in SynForm 2011, issue 2, A15-16 & as Cover (by Prof. M. Zanda);
in SynFacts 2011, issue 3, 310 (by Prof. P. Knochel);
in Organic Chemistry Highlights, 2011 Functionalization & Homologation of Alkenes (by Prof. D. F. Taber)

（9）Cyanative Alkene-Aldehyde Coupling: Ni(0)-NHC-Et2AlCN Mediated Chromanols Synthesis with High cis-Selectivity at room temperature. Ho, C.-Y.* Chem. Commun. 2010, 46, 466.

（8）Nitrile assisted, Bronsted acid catalyzed regio and stereoselective diarylphosphonylation of allyl silyl ethers. Ho, C.-Y.*; Chan, C.-W.; Wo, S.-K.; Zuo, Z.; Chan, L.-Y. Biomol. Chem. 2010, 8, 3480. (Highlighted in ChemInform (organoelement compounds))

（7）Alpha Olefins as Alkenylmetal Equivalents in Catalytic Conjugate Addition Reactions. Ho, C.-Y.; Ohmiya, H.; Jamison, T. F.* Angew. Chem. Int. Ed. 2008, 47, 1893.

（6）Highly Chemoselective Reductive Amination of Carbonyl Compounds Promoted by InCl3/Et3SiH/MeOH System. Lee, O.-Y.; Law, K.-L.; Ho, C.-Y.; Yang, D.* J. Org. Chem. 2008, 73, 8829.

（5）Highly Selective Coupling of Alkenes and Aldehydes Catalyzed by NHC–Ni–P(OPh)3: Synergy Between a Strong σ-Donor and a Strong π-Acceptor. Ho, C.-Y.; Jamison, T. F.* Angew. Chem. Int. Ed. 2007, 46, 782.
Highlighted twice:
in Angew. Chem. Int. Ed. as Hot Paper
in ChemInform (isocyclic compounds)

（4）Nickel-Catalyzed Coupling of Alkenes, Aldehydes, and Silyl Triflates. Ng, S.-S.; Ho, C.-Y.; Jamison, T. F.* J. Am. Chem. Soc. 2006, 128, 11513.

（3）Nickel-Catalyzed, Carbonyl-Ene-Type Reactions: Selective for Alpha Olefins and More Efficient with Electron-Rich Aldehydes. Ho, C.-Y.; Ng, S.-S.; Jamison, T. F.* J. Am. Chem. Soc. 2006, 128, 5326. Highlighted in ChemInform (isocyclic compounds)

（2）Fluorinated Chiral Secondary Amines as Catalysts for Epoxidation of Olefins with Oxone. Ho, C.-Y.; Chen, Y.-C.; Wong, M.-K.; Yang, D.* J. Org. Chem. 2005, 70, 898.

（1）Asymmetric epoxidation of olefins catalyzed by chiral iminium salts generated in-situ from chiral amines and aldehydes. Wong, M.-K.; Ho, L.-M.; Zheng, Y.-S.; Ho, C.-Y.; Yang, D.* Org. Lett. 2001, 3, 2587.