精细化工

1．有机磷化合物新的合成方法及其机理研究 2．过渡金属催化反应及其应用研究 3．药物与功能材料的设计开发

Dehydrogenation;Hydrogenation;Oxidative Coupling;Acid-catalyzed;Cleavage;Esters;Water;Azoles;Catalysis;Acylation

1. Zhixuan Xu,† Mengjie Cen,† Zihan Chen, Linbin Yao, Chunya Li,* Bencan Tang, Long Liu, Tianzeng Huang, Tieqiao Chen,* and Li-Biao Han*. Palladium-Catalyzed decarbonylative Michaelis−Arbuzov reaction of carboxylic acids and triaryl phosphites. Org. Lett., 2024, 26, 7004−7009.
2. Jin Zhang, Wei Hu, Zihan Chen, Nuo Wu, Chunya Li,* Tieqiao Chen, and Li-Biao Han*. Water-promoted mild and general Michaelis−Arbuzov reaction of triaryl phosphites and aryl iodides by palladium catalysis. Org. Lett., 2024, 26, 3386−3390.
3. Liguang Gan,† Changxu Ye,† Tianshu Pi, Lingling Wang, Chunya Li,* Long Liu, Tianzeng Huang, Tieqiao Chen,* and Li-Biao Han. Ligand-free iron-catalyzed construction of C−P bonds via phosphorylation of alcohols: synthesis of phosphine oxides and phosphine compounds. J. Org. Chem., 2024, 89, 7047−7057.
4. Chunya Li and Li-Biao Han*. Palladium-catalyzed solvent-free preparation of arylphosphonates ArP(O)(OAr)2 from (ArO)3P via the Michaelis–Arbuzov rearrangement. Organometallics, 2020, 39, 3613-3617.
5. Chunya Li, Yuta Saga, Shun-ya Onozawa, Shu Kobayashi, Kazuhiko Sato, Norihisa Fukaya, and Li-Biao Han*. Wet and dry processes for the selective transformation of phosphonates to phosphonic acids catalyzed by Brønsted acids. J. Org. Chem., 2020, 85, 14411–14419.
6. Chunya Li, Qi Wang, Jian-Qiu Zhang, Jingjing, Ye, Ju Xie, Qing Xu* and Li-Biao Han*. Water determines the products: an unexpected Brønsted acid-catalyzed PO-R cleavage of P(III) esters selectively producing P(O)–H and P(O)–R compounds. Green Chem., 2019, 21, 2916-2922.
7. Chunya Li, Tieqiao Chen* and Li-Biao Han*. Iron-catalyzed clean dehydrogenative coupling of alcohols with P(O)–H compounds: a new protocol for ROH phosphorylation. Dalton Trans., 2016, 45, 14893-14897.
8. Jian-Qiu Zhang, Jingzhuo Zhao, Chunya Li, Jingjing Ye, Li-Biao Han*.Conversion of
α‐hydroxy(2,4,6‐trimethylbenzyl)diphenylphosphine oxide to TPO: oxidation vs decomposition. Phosphorus, Sulfur, and Silicon and the Relat. Elem., 2021, 196, 207-210.
9. Kang Xiang, Shuo Zhang, Long Liu, Tianzeng Huang, Zhi Tang, Chunya Li,  Kaiqiang Xua, Tieqiao Chen*.Tunable C–H arylation and acylation of azoles with carboxylic acids by Pd/Cu cooperative catalysis. Org. Chem. Front., 2021, 8, 2543-2550.
10. Xinyi Li, Long Liu, Tianzeng Huang, Zhi Tang, Chunya Li, Wenhui Li, Tao Zhang, Zhaohui Li, Tieqiao Chen*. Palladium-catalyzed decarbonylative sonogashira coupling of terminal alkynes with carboxylic acids. Org. Lett., 2021, 23, 3304-3309.
11. Xue Liu, Long Liu, Tianzeng Huang, Jingjing Zhang, Zhi Tang, Chunya Li, Tieqiao Chen*. Trifluoromethylation of benzoic acids: an access to aryl trifluoromethyl ketones. Org. Lett., 2021, 23, 4930-4934.
12. Yuanyuan Tang, Kuan Liu, Jinjin Zhang, Long Liu*, Tianzeng Huang, Chunya Li, Zhi Tang, Tieqiao Chen*. Palladium-catalyzed stereoselective difunctionalization of bicyclic alkenes with organoammonium salts and organoboronic compounds. J. Org. Chem., 2021, 86, 11937-11947.
13. Tao Zhang, Kunyu Wang, Yuting Ke, Yuanyuan Tang, Long Liu*, Tianzeng Huang, Chunya Li, Zhi Tang, Tieqiao Chen*. Transition-metal-free and base promoted C–C bond formation via C–N bond cleavage of organoammonium salts. Org. Biomol. Chem., 2021, 19, 8237-8240.
14. Ying Lin, Dongyang Li, Jingjing Zhang, Zhi Tang*, Long Liu, Tianzeng Huang, Chunya Li, Tieqiao Chen*. I2/NaH2PO2-mediated deoxyamination of cyclic ethers for the synthesis of N-aryl-substituted azacycles. New J. Chem., 2021, 45, 21011-21014.
15. Kuan Liu, Bin Song, Qi Dang, Long Liu*, Jie Tang, Tianzeng Huang, Chunya Li, Zhi Tang, Tieqiao Chen*.Walking Cations: Transition-Metal Free Benzyl Cation-Triggered sp2 C—H Phosphorylation and Etherification. Chin. J. Chem., 2022,40, 2933-2938.
16. Tianhao Xu, Xingyu Zhou, Xiong Xiao, Yan Yuan, Long Liu, Tianzeng Huang, Chunya Li, Zhi Tang and Tieqiao Chen*.Nickel-Catalyzed Decarbonylative Thioetherification of Carboxylic Acids with Thiols. J. Org. Chem., 2022, 87, 13, 8672-8684.
17. Tianhao Xu, Wenhui Li, Kang Zhang, Yuhui Han, Long Liu, Tianzeng Huang, Chunya Li, Zhi Tang, and Tieqiao Chen*.Palladium-Catalyzed Decarbonylative Cyanation of Carboxylic Acids with TMSCN. J. Org. Chem., 2022, 87, 11871-11879.
18. Tianhao Xu, Xiangbing Zhou, Yuhui Han, Liangwei Zhang, Long Liu, Tianzeng Huang, Chunya Li, Zhi Tang, Shungang Wan*, Tieqiao Chen*. Palladium-catalyzed stereo-selective three-component cis-1,2-arylalkynylation of bicyclic alkenes with aryltriflates and terminal alkynes. Tetrahedron Let., 2022,97,153799.
19. Tao Zhang, Runji Wang, Jiani Chen, Long Liu*, Tianzeng Huang, Chunya Li, Zhi Tang and Tieqiao*. Base-promoted direct E-selective olefination of organoammonium salts with sulfones toward stilbenes and conjugated 1,3-dienes. Org. Biomol. Chem., 2022, 20, 4369-4375.

1. 李春娅，甘立广，樊晓璐，徐乐杰，陈铁桥，刘龙，黄添增，唐智.一种有机膦氧类化合物及其合成方法，2023，专利，授权。
2. 李春娅，张进，胡威，徐稚轩，杨西川，梁晨春紫.一种芳香膦酸酯类化合物及其合成方法，2023，专利，受理。
3. 李春娅，张进，胡威，徐稚轩，陈铁桥，刘龙，黄添增. 一种联芳烃类化合物及其合成方法，2024，专利，受理。
4. 李春娅，张进，胡威，徐稚轩，陈铁桥，刘龙，黄添增. 一种不对称双芳基酮类化合物及其合成方法，2024，专利，受理。
5. 李春娅，李金燕，叶长旭，胡威，皮天树，陈铁桥，刘龙，黄添增. 一种不对称烯烃类化合物及其合成方法，2024，专利，受理。
6. 李春娅，叶长旭，李金燕，彭燕欣，曾格格，丁海林，陈铁桥，刘龙，黄添增. 一种不对称烯烃类化合物及其合成方法，2024，专利，受理。
7. 李春娅，皮天树，胡威，周志诚，黄凌钰，陈铁桥，刘龙，黄添增. 一种N,N-二甲基酰胺类化合物及其合成方法，2025，专利，受理。
8. 李春娅，皮天树，胡威，周志诚，黄凌钰，陈铁桥，刘龙，黄添增. 一种酰胺类化合物及其合成方法，2025，专利，受理。

1. 国家自然科学基金青年基金项目，2023.01.01-2025.12.31，30万元，主持。
2. 海南省自然科学基金高层次人才项目，2022.01.01-2024.12.30,10万元，主持。
3. 海南省自然科学基金青年基金项目，2021.09-2024.06， 5万元，主持。
4. 海南大学科研启动基金项目，2020.11-2025.11，10万元，主持。
5. 国家级大学生创新训练项目，廉价金属催化醇和P(O)–H化合物脱水偶联合成含P–C键有机磷化合物研究，2021-2022，结题，指导老师。
6. 国家级大学生创新训练项目，过渡金属催化羧基导向C–H键活化构建C–P键反应的研究，2023-2024，结题，指导老师。
7. 国家级大学生创新训练项目，1,4-钯迁移策略高立体选择性合成烯基膦化合物的反应研究，2024-2025，在研，指导老师。

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