新材料,石油炼制,石油化工,精细化工,生物医药

分析化学

金纳米粒子;多肽;多孔硅基底;四氨基酞菁锌;微乳液;蛋白质检测;微波法合成;稀土掺杂上转换纳米粒子;2型糖尿病;共振光散射

Gold Nanoparticles;Nanoparticles;Gold Nanoparticle;Multidisciplinary;Humanities And Social Sciences;Science;Resonance Light Scattering;Colorectal Cancer;Cancer Genomics;Molecular Medicine

1、结合微电子及微加工技术将所研制的分析方法器件化并研制基于低频微振荡的微阵列生物芯片点样装置和基于波导激发的微阵列生物芯片检测装置工程样机3台/套，其中2台已在中科院化学所和国家纳米中心推广试用；构建2台电化学联用超分辨率测量时间分辨表面等离子体共振光谱仪样机，并已推广应用到上海鉴源检测技术有限公司和佛山中科先创电子科技有限公司。
2、与潍坊市康华生物技术有限公司、润方（长春）生物科技有限公司合作研发体外诊断试剂盒，2种新冠血清抗体检测卡已获得CE证书；患者血液中循环肿瘤DNA BRAFV600E突变和循环结直肠肿瘤细胞检测试剂盒已进入临床实验阶段并获得了山东省泰山产业领军人才项目（战略新兴）的资助。

1. Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications Fuyao Liu, Xiuxia He, Hongda Chen, Junping Zhang, Huimao Zhang and Zhenxin Wang Nature Communications 2015, 6, 8003
2. Construction of lanthanide-doped upconversion nanoparticle-Uelx Europaeus Agglutinin-I bioconjugates with brightness red emission for ultrasensitive in vivo imaging of colorectal tumor, Rongrong Tian. Shuang Zhao. Liu, Guifeng. Hongda Chen. Lina Ma. Hongpeng You. Liu, Chunming*. Zhenxin Wang*, BIOMATERIALS, 2019, 212: 64-72.1.
3. Uncovering the Binding Specificities of Lectins with Cells for Precision Colorectal Cancer Diagnosis Based on Multimodal Imaging, Rongrong Tian, Hua Zhang, Hongda Chen, Guifeng Liu*, Zhenxin Wang*, Adv. Sci. 2018, 1800214.
4. Employing Tryptone as a General Phase Transfer Agent to Produce Renal Clearable Nanodots for Bioimaging Fuyao Liu, Xiuxia He, Junping Zhang, Huimao Zhang and Zhenxin Wang Small 2015, 11(30): 3676-3685.
5. Peptide Microarray-Based Metal Enhanced Fluorescence Assay for Multiple Profiling of Matrix Metalloproteinases Activities, Zhen Lei, Hua Zhang, Yaoqi Wang, Xianying Meng*, Zhenxin Wang*, Anal. Chem. 2017, 89, 6749-6757.
6. Sensitive Detection of Polynucleotide Kinase Activity by Paper-Based Fluorescence Assay with lambda Exonuclease Assistance Hua Zhang. Zhen Zhao. Zhen Lei. Zhenxin Wang* Anal. Chem. 2016, 88(23): 11358-11363.
7. Evaluation of Matrix Metalloproteinase Inhibition by Peptide Microarray-Based Fluorescence Assay on Polymer Brush Substrate and in Vivo Assessment, Zhen Lei, Hongda Chen, Hua Zhang, Yaoqi Wang, Xianying Meng*, Zhenxin Wang*, ACS Appl. Mater. Interfaces 2017, 9, 44241-44250.
8. Poly(glycidyl methacrylate-co-2-hydroxyethyl methacrylate) Brushes as Peptide/Protein Microarray Substrate for Improving Protein Binding and Functionality, Zhen Lei, Jiaxue Gao, Xia Liu, Dianjun Liu, and Zhenxin Wang*, ACS Appl. Mater. Interfaces, 2016, 8, 10174？10182.

1. Size-controlled Synthesis of Near-Monodisperse Gold Nanoparticles in the 1-4 Nm Range Using Polymeric Stabilizers.
I Hussain; S Graham; ZX Wang; B Tan; DC Sherrington; SP Rannard; AI Cooper; M Brust
Journal of the American Chemical Society, 2005

2. Gold Nanoparticle Probes
Zhenxin Wang; Lina Ma
COORDINATION CHEMISTRY REVIEWS, 2009

3. Kinase-Catalyzed Modification of Gold Nanoparticles: A New Approach to Colorimetric Kinase Activity Screening
ZX Wang; R Levy; DG Fernig; M Brust
Journal of the American Chemical Society, 2006

4. Gram-scale Synthesis of Coordination Polymer Nanodots with Renal Clearance Properties for Cancer Theranostic Applications
Fuyao Liu; Xiuxia He; Hongda Chen; Junping Zhang; Huimao Zhang; Zhenxin Wang
Nature Communications, 2015

5. Nonenzymatic Amperometric Determination of Glucose by Cuo Nanocubes-Graphene Nanocomposite Modified Electrode
Liqiang Luo; Limei Zhu; Zhenxin Wang
Bioelectrochemistry, 2012

6. Fluorescence Resonance Energy Transfer Quenching at the Surface of Graphene Quantum Dots for Ultrasensitive Detection of TNT.
Lishuang Fan; Yuwei Hu; Xiao Wang; Linlin Zhang; Fenghua Li; Dongxue Han; Zhenggang Li; Qixian Zhang; Zhenxin Wang; Li Niu
Talanta, 2012

7. Design of Polymeric Stabilizers for Size-Controlled Synthesis of Monodisperse Gold Nanoparticles in Water.
Zhenxin Wang; Bien Tan; Irshad Hussain; Nicolas Schaeffer; Mathias Brust; Andrew I. Cooper
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007

8. Towards Multistep Nanostructure Synthesis: Programmed Enzymatic Self‐Assembly of DNA/Gold Systems
AG Kanaras; ZX Wang; AD Bates; R Cosstick; M Brust
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003

9. Facile Preparation of Doxorubicin‐Loaded Upconversion@Polydopamine Nanoplatforms for Simultaneous in Vivo Multimodality Imaging and Chemophotothermal Synergistic Therapy
Fuyao Liu; Xiuxia He; Zhen Lei; Liang Liu; Junping Zhang; Hongpeng You; Huimao Zhang; Zhenxin Wang
Advanced Healthcare Materials, 2014

10. B7-H3 Promotes Aerobic Glycolysis and Chemoresistance in Colorectal Cancer Cells by Regulating HK2
Tongguo Shi; Yanchao Ma; Lei Cao; Shenghua Zhan; Yunyun Xu; Fengqing Fu; Cuiping Liu; Guangbo Zhang; Zhenxin Wang; Ruoqin Wang; Huimin Lu; Binfeng Lu; Weichang Chen; Xueguang Zhang
Cell Death and Disease, 2019