刘敏 教授 博士 山东省 研究领域: 新材料,石油炼制,石油化工,精细化工,生物医药 研究方向: 物理化学 所在单位: 聊城大学

基本信息

所在单位:
聊城大学
机构细分:
化学化工学院
单位类型:
高等院校
职务:
教授
职称:
教授
最高学历:
博士
教育经历:
1991.09–1995.07,青岛科技大学/有机化工专业,学士
1998.09–2001.02,北京理工大学/化学工程专业,硕士
2004.09–2007.07,浙江大学/物理化学专业,博士
工作经历:
1995.9 –1998.7,聊城师范学院化学系任教;
2001.2-2004.7,聊城大学化学化工学院任教;
2007.9-2015.7,聊城大学化学化工学院任教;
2015.7– 至今,聊城大学生物制药研究院任教。
专家介绍:
主持国家自然科学基金课题3项(“多糖类药物载体靶向控释的抗癌药物与靶标DNA相互作用的化学热力学研究,21103079”;“儿茶素类天然生化调节剂-抗癌药物协同体系与蛋白质相互作用的量热学-谱学研究,21473085”;“靶向DNA纳米结构与化疗-光疗联合药物相互作用的微量热和谱学研究,22073039”),山东省重点研发计划项目1项(紫杉醇人血白蛋白纳米粒药物制剂的研究与开发,2015GSF118160),山东省自然科学基金面上项目1项(核酸自组装纳米结构共加载茶多酚-化疗药物的热力学研究,ZR2020MB052)。参与国家自然科学基金课题2项,在The Journal of Chemical Thermodynamics、Journal of Molecular Liquids、Journal of Chemical & Engineering Data, Spectrochimica  Acta、Journal of Agricultural and Food Chemistry、Food Chemistry、化学学报、物理化学学报等国内外有较大影响的专业学术期刊上首位或通讯联系人发表论文100余篇,授权发明专利3项。获省教育厅高校优秀科研成果奖5项,聊城大学优秀科研成果奖多项。
专家荣誉:
2021年,聊城大学“光岳英才”第二层次
2019年,山东省高等学校优秀科研成果二等奖
2016年,山东省高等学校优秀科研成果三等奖
2020年,聊城大学优秀科研成果一等奖
2018年,聊城大学优秀科研成果二等奖
2017年,聊城大学优秀科研成果二等奖

科研能力

研究领域:
新材料,石油炼制,石油化工,精细化工,生物医药
研究方向:
物理化学
英文标签:
Isothermal Titration Calorimetry;Interaction;Molecular Docking;Cytotoxicity;Spectroscopy;Human Serum Albumin;Bovine Serum Albumin;Antioxidant Activity;Fluorescence Spectroscopy;(-)-epigallocatechin-3-gallate (egcg)
研究成果:
(1)  “紫杉醇人血白蛋白纳米粒药物制剂的研究与开发”鉴定为国际先进水平
论文著作:
(1) Tingting Liu; Min Liu*; et al. Co-encapsulation of (−)-epigallocatechin- 3-gallate and piceatannol/oxyresveratrol in -lactoglobulin: effect of ligand–protein binding on the antioxidant activity, stability, solubility and cytotoxicity, Food Funct., 2021, 12, 7126 (SCI 1区,封面文章)

(2) Yinglin Liu; Min Liu*; et al. Enhanced solubility of bisdemethoxycurcumin by interaction with Tween surfactants: Spectroscopic and coarse-grained molecular dynamics simulation studies, J. Mol. Liq., 2021, 323, 115073 (SCI 2区).

(3) Danfeng Wang; Min Liu*; et al. Self-assembled DNA nanotrains for targeted delivery of mithramycin dimers coordinated by different metal ions: Effect of binding affinity on drug loading, release and cytotoxicity, J. Mol. Liq., 2021, 339, 116722 (SCI 2区).

(4) He Liu; Min Liu*; et al. Competitive binding of synergistic antioxidant chlorogenic acid and (-)-epigallocatechin gallate with lysozyme: Insights from multispectroscopic characterization, molecular docking and activity evaluation, J. Mol. Liq., 2021, 341, 117387 (SCI 2区).

(5) Tingting Liu; Min Liu*; et al. Investigation of binary and ternary systems of human serum albumin with oxyresveratrol/piceatannol and/or mitoxantrone by multipectroscopy, molecular docking and cytotoxicity evaluation, J. Mol. Liq., 2020, 311, 113364 (SCI 2区).

(6) Wenxin Pei; Min Liu*; et al. High payload and targeted release of anthracyclines by aptamer-tethered DNA nanotrains – Thermodynamic and release kinetic study, Eur. J. Pharm. Sci., 2020, 148, 105319 (SCI 2区).

(7) Min Liu*; et al. Comparative study on the interaction of oxyresveratrol and piceatannol with trypsin and lysozyme: binding ability, activity and stability, Food Funct., 2019, 10: 8182–8194 (SCI 1区).

(8) Qingying Guo; Min Liu*; et al. Spectroscopic and cytotoxicity studies on the combined interaction of (−)-epigallocatechin-3-gallate and anthracycline drugs with human serum albumin, Spectrochim. Acta A, 2019, 222: 117213 (SCI 2区).

(9) Yabo Shi; Min Liu*; et al. Mutual influence of piceatannol and bisphenol F on their interactionwith pepsin: Insights fromspectroscopic, isothermal titration calorimetry and molecular modeling studies, Spectrochim. Acta A, 2019, 206: 384–395 (SCI 2区).

(10) Chang Cai; Min Liu*; et al. A combined calorimetric, spectroscopic and molecular dynamic simulation study on the inclusion complexation of (E)-piceatannol with hydroxypropyl--cyclodextrin in various alcohol + water cosolvents, J. Chem. Thermodyn., 2019, 132: 341–351 (SCI 2区).

(11) Lixia Yuan; Min Liu*; et al. Calorimetric and spectroscopic studies on the competitive behavior between (−)-epigallocatechin-3-gallate and 5-fluorouracil with human serum albumin, J. Mol. Liq., 2017, 248: 330–339 (SCI 2区).

(12) Lixia Yuan; Min Liu*; et al. Competitive binding of epigallocatechin-3-gallate and 5-fluorouracil to human serum albumin: A fluorescence and circular dichroism study, Spectrochim. Acta A, 2017, 173: 584–592 (SCI 2区).

(13) Min Liu*; et al. Improved stability of (+)-catechin and (-)-epicatechin by complexing with hydroxypropyl-β-cyclodextrin: Effect of pH, temperature and configuration, Food Chem., 2016, 196: 148–154 (SCI 1区).

(14) Chunmei Wang; Min Liu*; et al. Calorimetric and spectroscopic studies on temperature- and pH-dependent interactions of stimuli-responsive poly (N-isopropyl acrylamide) with piceatannol, J. Chem. Thermodyn., 2016, 98: 186–192 (SCI 2区).

(15) Yan Zheng; Min Liu*; et al. Simultaneous determination of enthalpies of dilution and dissociation of protocatechuic acid in aqueous salt solutions by calorimetric measurements, J. Chem. Thermodyn., 2015, 91: 177–185 (SCI 2区) .
发明专利:
(1) 授权专利:一种药物-磷脂/白蛋白复合纳米粒及制备工艺, ZL 201711044667.1;一种尼莫地平固体分散体及其片剂制备方法,ZL 201711390110.3
科研项目:
靶向DNA纳米结构与化疗-光疗联合药物相互作用的微量热和谱学研究,国家自然科学基金,2021-2024,主持
儿茶素类天然生化调节剂-抗癌药物协同体系与蛋白质相互作用的量热学-谱学研究,国家自然科学基金,2015–2018,主持
多糖类药物载体靶向控释的抗癌药物与靶标DNA相互作用的化学热力学研究,国家自然科学基金,2012–2014,主持
核酸自组装纳米结构共加载茶多酚-化疗药物的热力学研究,省自然科学基金,2021-2023,主持
紫杉醇人血白蛋白纳米粒药物制剂的研究与开发,山东省重点研发计划项目,2016–2018,主持
智能响应型药物载体对难溶性抗癌药物的增溶及靶向控释研究,山东省抗体制药协同创新中心开放课题,2018-2020,主持

项目合作

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