精细化工

生物催化与绿色化工

1. Liu Y, Zhu L, Li X, Cui Y, Roosta A, Feng J*, Chen X,Yao P, Wu Q*, Zhu D*(2023)Photoredox/Enzymatic Catalysis Enabling Redox-Neutral Decarboxylative Asymmetroc C-C Coupling for Asymmetric Synthesis of Chiral 1,2-Amino Alcohols.
JACS Au, https://doi.org/10.1021/jacsau.3c00366.
2. Xu Z, Feng J, Yao P, * Wu Q * and Zhu D*(2023)Chemo-enzymatic Synthesis of Chiral 3-substituted Tetrahydroquinolines by a Sequential Biocatalytic Cascade and Buchwald–Hartwig Cyclization. Green Chem., 25: 4667-4673, doi: 10.1039/d3gc00047h
3. Zhou C, Chen X,* Lv T, Han X, Feng J, Liu W, Wu Q,* Zhu D* (2023) Flipping the Substrate Creates a Highly Selective Halohydrin Dehalogenase for the Synthesis of Chiral 4‑Aryl-2-oxazolidinones from Readily Available Epoxides. ACS Catal.,13: 4768-77 doi.org/10.1021
/acscatal.2c06417
4. Feng J, Wu Q, Zhu D*, Ma Y (2022) Biotransformation Enables Innovations Toward Green Synthesis of Steroidal Pharmaceuticals. ChemSusChem, e202102399 doi:10.1002/cssc.202102399
5. Wang Y, Zhang R, Feng J, Wu Q*, Zhu D*, Ma Y (2022) A New 3-Ketosteroid-Delta(1)-Dehydrogenase with High Activity and Broad Substrate Scope for Efficient Transformation of Hydrocortisone at High Substrate Concentration. Microorganisms, 10(3) doi:10.3390/microorganisms10030508
6. Li Y, Hu N, Xu Z, Cui Y, Feng J, Yao P*, Wu Q*, Zhu D*, Ma Y (2022) Asymmetric Synthesis of N-Substituted 1,2-Amino Alcohols from Simple Aldehydes and Amines by One-Pot Sequential Enzymatic Hydroxymethylation and Asymmetric Reductive Amination.  Angew. Chem. Int. Ed., 61(17): e202116344 doi:10.1002/anie.202116344
7. Liu N, Wu L, Feng J, Sheng X, Li J, Chen X, Li J, Liu W, Zhou J*, Wu Q*, Zhu D* (2021) Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids. Angew. Chem. Int. Ed., 60: 10203-10210 doi:10.1002/anie.202017225
8. Yu S, Li J, Yao P, Feng J, Cui Y, Li J, Liu X, Wu Q*, Lin J*, Zhu D* (2021) Inverting the Enantiopreference of Nitrilase-Catalyzed Desymmetric Hydrolysis of Prochiral Dinitriles by Reshaping the Binding Pocket with a Mirror-Image Strategy. Angew. Chem. Int. Ed. 60(7): 3679-3684 doi:10.1002/anie.202012243
9. Xu Z, Yao P, Sheng X, Li J, Li J, Yu S, Feng J, Wu Q*, Zhu D* (2020) Biocatalytic Access to 1,4-Diazepanes via Imine Reductase-Catalyzed Intramolecular Asymmetric Reductive Amination. ACS Catal., 10(15): 8780-8787 doi:10.1021/acscatal.0c02400
10. Chen X, Zhang H, Maria-Solano MA, Liu W, Li J, Feng J, Liu X, Osuna S*, Guo R-T, Wu Q*, Zhu D*, Ma Y (2019) Efficient Reductive Desymmetrization of Bulky 1,3-cyclodiketones Enabled by Structure-guided Directed Evolution of a Carbonyl Reductase. Nat. Catal., 2(10): 931-941 doi:10.1038/s41929-019-0347-y5
11. Liu N, Feng J, Zhang R, Chen X, Li X, Yao P, Wu Q*, Ma Y, Zhu D* (2019) Efficient microbial synthesis of key steroidal intermediates from bio-renewable phytosterols by genetically modified Mycobacterium fortuitum strains. Green Chem., 21(15): 4076-4083 doi:10.1039/c9gc01267b