论文著作：
Dongqin Ding#, Yaru Zhu#, Danyang Bai, Tongxin Wan, Sang Yup Lee*, Dawei Zhang*. Monitoring and dynamically controlling glucose uptake rate and central metabolism. Nature Chemical Engineering. 2025 Jan 17;2: 50–62.
Linxia Liu#, Jinlong Li#, Yuanming Gai#, Zhizhong Tian, Yanyan Wang, Tenghe Wang, Pi Liu, Qianqian Yuan, Hongwu Ma, Sang Yup Lee*, Dawei Zhang*. Protein engineering and iterative multimodule optimization for vitamin B6 production in Escherichia coli, Nature Communications. 2023 Aug 31;14(1):5304.
Qian Kang, Huan Fang, Mengjie Xiang, Kaixing Xiao, Pingtao Jiang, Chun You, Sang Yup Lee*, Dawei Zhang*. A synthetic cell-free 36-enzyme reaction system for vitamin B (12) production, Nature Communications. 2023 Aug 24;14(1):5177.
Jinlong Li#, Sijia Wang#, Cui Liu, Yixin Li, Yu Wei, Gang Fu, Pi Liu, Hongwu Ma, Dawei Huang, Jianping Lin*, and Dawei Zhang*, Going beyond the local catalytic activity space of chitinase using a simulation-based iterative saturation mutagenesis strategy, ACS Catalysis, 2022, 12, 16, 10235−10244.
Yali Cui#, Huina Dong#, Baisong Tong, Huiying Wang, Xipeng Chen, Guangqing Liu, Dawei Zhang*, A versatile Cas12k-based genetic engineering toolkit (C12KGET) for metabolic engineering in genetic manipulation-deprived strains, Nucleic Acids Research. 2022 Aug 26;50(15):8961-8973.
Gang Fu, Jie Yue, Dandan Li, Yixin Li, Sang Yup Lee*, Dawei Zhang*，An operator-based expression toolkit for Bacillus subtilis enables fine-tuning of gene expression and biosynthetic pathway regulation, Proc Natl Acad Sci U S A. 2022 Mar 15; 119(11):e2119980119.
Dongqin Ding#, Jinlong Li#, Danyang Bai, Huan Fang, Jianping Lin*, Dawei Zhang*, Biosensor-based monitoring of the central metabolic pathway metabolites, Biosensors and Bioelectronics. 2020 Nov 1;167: 112456.
Huan Fang, Dong Li, Jie Kang, Pingtao Jiang, Jibin Sun, Dawei Zhang*. Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B12. Nature Communications. 2018 Nov 21;9(1):4917.
张大伟
天津市
研究领域：
生物医药
研究方向：
维生素生物合成，微生物蛋白合成与高效表达系统，微生物细胞工厂与代谢工程，合成生物技术，生物化工
所在单位：
中国科学院天津工业生物技术研究所
