生物医药

1. 利用合成生物学的理念与技术，开展功能性营养物质生物合成的底层创新设计，研发一碳和生物质利用等多场景应用的微生物源蛋白和功能性营养资源开发与应用技术；
2. 基于人类和动物营养代谢及其生理功能，研发新型微生物蛋白、功能性肽、核苷酸及有机微量元素等营养物质生物合成与应用关键技术。

1.Le Gao*,Khoo Shing Ching,Zhaokun Zhang,Xin Wu*. Trends in Sustainable Production of Advanced Single-Cell Protein Manufacturing from Non-grain Feedstocks. Trends in Biotechnology,2025,DOI: 10.1016/j.tibtech.2025.04.018
2.Le Gao,Jie Yuan,Kai Hong,Xin Wu*. Advancing Pichia pastoris: A Next-Generation Platform for Sustainable Biomanufacturing. Biotechnology advances,2025,82(6):108593
3.Le Gao,Fangting Jiang,Zhaokun Zhang,Daochen Zhu,Xin Wu.Unlocking lignin valorization and harnessing lignin-based raw materials for bio-manufacturing. Science China. Life sciences,2025:DOI: 10.1007/s11427-024-2792-x
4.Jinyang Li,Fangting Jiang,Changyu Pi,Tongtong Bao,Le Gao,Xin Wu*. Multi-omic profiling of a novel Myrothecium species reveals its potential mechanism of lignin degradation. International Journal of Biological Macromolecules,2024: 282(Pt 5):137134
5.Le Gao#,Xiaolin Li,Yumeng Li,Zhaokun Zhang,Jialu Wang,Chao Xu,Wu Xin*. Biochemical characterization,biosynthesis mechanism,and functional evaluation of selenium-enriched aspergillus oryzae A02. International Journal of Biological Macromolecules,2024,275:133714
6.Yumeng Li,Xutong Tian,Juyue Luo,Tongtong Bao,Shujin Wang,Xin Wu*. Molecular mechanisms of aging and anti-aging strategies. Cell Communication and Signaling,2024,22(1):285
7.Jianying Yang,Juyue Luo,Xutong Tian,Yumeng Li*,Xin Wu*. Progress in Understanding Oxidative Stress,Aging,and Aging-Related Diseases,Antioxidants,2024,13(4):394
8.Yumeng Li,Tongtong Bao,Lumin Gao,Qian Yu,Xutong Tian,Haofan Dong,Ran Duan,Kaimin Niu,Jianying Yang,Shujin Wang,Xin Wu*. Alleviation of hepatic insulin resistance and steatosis with NMN via improvement in endoplasmic reticulum-mitochondria miscommunication in the liver of HFD mice. Biomedicine & Pharmacotherapy,2024,175: 116682
9.Yingying Feng,Yuying Wu,Jialu Wang,Zhenglin Dong,Qian Yu,Chunxue Liu,Haihua Wang,Xin Wu*. Enteromorpha prolifera polysaccharide-Fe (III) complex promotes intestinal development as a new iron supplement.SCIENCECHINA Life Sciences,2024:219-231
10.Yingying Feng,Teketay Wassie,Yuying Wu,Xin Wu*. Advances on novel iron saccharide-iron (III) complexes as nutritional supplements. Critical Reviews in Food Science and Nutrition,2024,DOI: 10.1080/10408398.2023.2222175
11.Yingying Feng,Renyou Gan,Wai San Cheang,Xin Wu*. Editorial: Immunometabolism and Nutritional Regulation of Intestinal Mucosal Immunity,2024,15:1365690
12.Gao L,Meng J,Wuling Dai,Zhaokun Zhang,Haofan Dong,Qianqian Yuan,Wuyuan Zhang,Liu SG,Wu Xin*. Deciphering cell wall sensors enabling the construction of robust P. pastoris for single-cell protein production. Biotechnology for Biofuels and Bioproducts,2023 DOI: 10.1186/s13068-023-02428-7
13.Meng Jiao,Liu Shufan,Gao Le,Hong Kai,Liu Shuguang,Wu Xin*. Economical production of Pichia pastoris single cell protein from methanol at industrial pilot scale. Microbial Cell Factories,2023,22: 198
14.Le Gao,Zhuohang Yu,Shengjie Wang,Yuejie Hou,Shouchang Zhang,Chichun Zhou*,Wu Xin*. A new paradigm in lignocellulolytic enzyme cocktail optimization: free from expert-level prior knowledge and experimental datasets. Bioresource Technology,2023,(388):29758
15.Yingying Feng,Teketay Wassie,Renyou Gan*,Xin Wu*. Structural Characteristics and Immunomodulatory Effects of Sulfated Polysaccharides Derived from Marine Algae. Critical Reviews in Food Science and Nutrition,2023,63: 7180–7196
16.Shujin Wang*,Wei Fu,Xueya Zhao,Xiaojiao Chang,Hujun Liu,Lin Zhou,Jian Li,Rui Cheng,Xin Wu*,Xi Li*,Changpo Sun*. Mycotoxin disturbs the reproductive-immune axis: the role of gut microbial metabolites. Microbiome,2022,10:234
17.Yin Jie,Yuying Li,Hui Han,Shuai Chen,Jing Gao,Gang Liu,Xin Wu*,Jinping Deng,Xingguo Huang,Rejun Fang,Tiejun Li*,Russel J. Reiter,Guoqiang Zhu,Wenkai Ren*,Yulong Yin. Melatonin improves lipid metabolism by reprograming gut microbiota and microbiota-derived acetic acid. Journal of Pineal Research,2018,65:e12524