论文著作：
1. Changyu Pi, Jinyang Li, Tongtong Bao, Le Gao*, Xin Wu*. Integrated base editing and microfluidics boost microbial lipid production from lignin. Bioresource Technology. 2026, 440, 133441.
2. Le Gao*, KS Ching, Zhaokun Zhang, Xin Wu*. Trends in Sustainable Single-Cell Protein from Non-grain Feedstocks. Trends in biotechnology. DOI: 10.1016/j.tibtech.2025.04.018.
3. Le Gao, Jie Yuan, Kai Hong, Xin Wu*. Technological advancement spurs Komagataella phaffii as a next-generation platform for sustainable biomanufacturing. Biotechnology advances. 2025, 82, 108593.
4. Le Gao, Tiantian Zhou, Jie Yuan, Shouchang Zhang, Kai Hong, Zhaokun Zhang, Lee Chia Hau, Wai San Cheang, Chichun Zhou, Xin Wu*. AI-powered de novo architecturing of marine-mimetic antioxidant peptides in yeast synbio factories. Chemical Engineering Journal. 2025, 524, 169604.
5. Jinyang Li, Changyu Pi, Jintong Zhang, Fangting Jiang, Tongtong Bao, Le Gao*, Xin Wu*. Fungal bioconversion of lignin-derived aromatics: Pathways, enzymes, and biotechnological potential. Biotechnology advances. 2025, 83, 108624.
6. Le Gao, Fangting Jiang, Zhaokun Zhang, Tongtong Bao, Daochen Zhu, Xin Wu*. Unlocking lignin valorization and harnessing lignin-based raw materials for bio-manufacturing. Science china life sciences. 2025, 68, 994-1009.
7. Le Gao, Jiajun Sun, Zhaokun Zhang, Xin Wu*. Systems Metabolic Engineering of Phaffia rhodozyma for Ultra-High Astaxanthin Production through Multiple Strategies. Science china life sciences. 2025, doi: 10.1007/s11427-025-3005-3.
8. Fengyun Ren, Fan Wu, Chengyu Jie, Le Gao*, Xin Wu*. Carbon-nitrogen metabolic coupling for optimized protein production of corn stover polysaccharides: From molecular mechanisms to buffalo rumen microbiome. International Journal of Biological Macromolecules. 2025, 320, 145901.
9. Le Gao, Xin Wu*. Biochemical characterization, biosynthesis mechanism, and functional evaluation of selenium-enriched Aspergillus oryzae A02. International Journal of Biological Macromolecules. 2024, 275, 133714.
10. Le Gao, Zhuohang Yu, Shengjie Wang, Yuejie Hou, Shouchang Zhang, Chichun Zhou*, Xin Wu*. A new paradigm in lignocellulolytic enzyme cocktail optimization: Free from expert-level prior knowledge and experimental datasets. Bioresource Technology. 2023, 388,12975.
11. Le Gao, Jiao Meng, Wuling Dai, Zhaokun Zhang, Haofan Dong, Qianqian Yuan, Wuyuan Zhang, Shuguang Liu, Xin Wu*. Deciphering cell wall sensors enabling the construction of robust P. pastoris for single-cell protein production. Biotechnology for Biofuels and Bioproducts. 2023, 16, 178.
12. Le Gao, Yi Jiang, Kai Hong, Xiaoyi Chen*, Xin Wu*. Glycosylation of cellulase: a novel strategy for improving cellulase. Critical Reviews in Biotechnology. 2022, 1:11.
高乐
天津市
研究领域：
生物医药
研究方向：
（1）研发低值原料规模化生物合成微生物蛋白的适配体系及绿色生产工艺，开发功能性饲用/食用蛋白原料，并开展应用关键技术研发与产业化示范。
（2）创制功能性肽、功能蛋白、抗氧化产物等营养物质生物合成的关键技术，并开展应用关键技术研发与产业化示范。
所在单位：
中国科学院天津工业生物技术研究所
