生物医药

阐明重要工业微生物合成特定代谢产物的分子基础和调控机制，并利用代谢工程、合成生物技术、生物传感技术等方法，构建高效微生物细胞工厂，生产氨基酸、有机酸以及高附加值化学品。

[1] Yun Ju, Hongyu Zhang, Xiaocong Du, Jingxuan Wei, Jun Liu,Liang Wei*, Qingdai Liu*, Ning Xu*.DRAGON: Harnessing the power of DNA repair for accelerating genome evolution in Corynebacterium glutamicum[J].Metabolic Engineering, 2023, 79: 182-191.
[2] Huanmin Du, Yuting Qi, Jinfang Qiao, Lingcong Li, Ning Xu, Li Shao, Liang Wei*, and Jun Liu*. Balancing Redox Homeostasis to Improve l-Cysteine Production in Corynebacterium glutamicum[J]. Journal of Agricultural and Food Chemistry, 2023, 71(37): 13848-13856.
[3] Huanmin Du, Jinfang Qiao, Yuting Qi, Lingcong Li, Ning Xu, Li Shao, Liang Wei*and Jun Liu*. Reprogramming the sulfur recycling network to improve l-cysteine production in Corynebacterium glutamicum[J]. Green Chemistry, 2023, 25(8): 3152-3165.
[4] Jinshan Gao, Muhua Du, Jinhua Zhao, Yue zhang, Ning Xu, Huanmin Du, Jiansong Ju, Liang Wei*, Jun Liu*. Design of a genetically encoded biosensor to establish a high-throughput screening platform for L-cysteine overproduction[J]. Metabolic Engineering, 2022, 73: 144-157.
[5] Liang Wei, Jinhua Zhao, Yiran wang, Jinshan Gao, Muhua Du, Yue zhang, Ning Xu, Huanmin Du, Jiansong Ju, Qingdai Liu*, Jun Liu*. Engineering of Corynebacterium glutamicum for high-level γ-aminobutyric acid production from glycerol by dynamic metabolic control[J]. Metabolic Engineering, 2022, 69: 134-146.
[6] Liang Wei, Qian Wang, Ning Xu, Jian Cheng, Wei Zhou, Guoqiang Han, Huifeng Jiang*, Jun Liu*, and Yanhe Ma.Combining protein and metabolic engineering strategies for high-level production of O-acetylhomoserine in Escherichia coli[J]. ACS Synthetic Biology, 2019, 8(5): 1153-1167.
[7] Liang Wei, Hao Wang, Ning Xu, Wei Zhou, Jiansong Ju*, Jun Liu*, Yanhe Ma. Metabolic engineering of Corynebacterium glutamicum for L-cysteine production[J]. Applied microbiology and biotechnology, 2019, 103: 1325-1338.
[8] Liang Wei, Ning Xu, Yiran Wang, Wei Zhou, Guoqiang Han, Yanhe Ma & Jun Liu*. Promoter library-based module combination (PLMC) technology for optimization of threonine biosynthesis in Corynebacterium glutamicum[J]. Applied microbiology and biotechnology, 2018, 102: 4117-4130.
[9] Liang Wei, Jiao Liu, Haishan Qi, Jianping Wen. Engineering Scheffersomyces stipitis for fumaric acid production from xylose[J]. Bioresource technology, 2015, 187: 246-254.