生物医药

工业丝状真菌发酵L-苹果酸、纤维素乙醇、L-乳酸等大宗化学品和糖化酶等工业蛋白质的生产过程优化控制与放大

Wang H#, Sun T#, Zhao Z, Gu S, Liu Q, Wu T, Wang D, Tian C, Li J*. Transcriptional Profiling of Myceliophthora thermophila on Galactose and Metabolic Engineering for Improved Galactose Utilization. Front Microbiol. 2021;12.
Zhang Y, Sun T, Wu T, Li J, Hu D, Liu D, Li J, Tian C*. Consolidated bioprocessing for bioethanol production by metabolically engineered cellulolytic fungus Myceliophthora thermophila. Metab Eng. 2023; 78:192-199.
Li J, Lin L, Sun T, Xu J, Ji J, Liu Q, Tian C*. Direct production of commodity chemicals from lignocellulose using Myceliophthora thermophila. Metab Eng. 2019;61 (2020 ):416–26.
Zhao J, Li Q, Sun T, Zhu X, Xu H, Tang J, Zhang X*, Ma Y. Engineering central metabolic modules of Escherichia coli for improving β-carotene production. Metab Eng. 2013; 17:42-50.
Sun T, Miao L, Li Q, Dai G, Lu F, Liu T, Zhang X*, Ma Y. Production of lycopene by metabolically-engineered Escherichia coli. Biotechnol Lett. 2014;36(7):1515-22.
Li, J; Zhang, Y; Li, J; Sun, T; Tian, C*. Metabolic engineering of the cellulolytic thermophilic fungus Myceliophthora thermophila to produce ethanol from cellobiose. Biotechnol Biofuels 2020,13:23.
Zhu Z, Zhang M, Liu D, Liu D, Sun T, Yang Y,Dong J, Zhai h, Sun W, Liu Q, Tian C*. Development of the thermophilic fungus Myceliophthora thermophila into glucoamylase hyperproduction system via the metabolic engineering using improved AsCas12a variants. Microb Cell Fact.2023 ;11;22(1):150.
Guo W, Liu D, Li J, Sun W, Sun T,Wang X, Wang K, Liu Q, Tian C*. Manipulation of an α-glucosidase in the industrial glucoamylase-producing Aspergillus niger strain O1 to decrease non-fermentable sugars production and increase glucoamylase activity. Front Microbiol. 2022;20:13.
Li J#, Chen B#, Gu S#, Zhao Z, Liu Q, Sun T, Zhang Y, Wu T, Liu D, Sun W, Tian C*. Coordination of consolidated bioprocessing technology and carbon dioxide fixation to produce malic acid directly from plant biomass in Myceliophthora thermophila. Biotechnol Biofuels. 2021;14(1):186.
Gu, S#; Li, J#; Chen, B; Sun, T; Liu, Q; Xiao, D; Tian, C* Metabolic engineering of the thermophilic filamentous fungus Myceliophthora thermophila to produce fumaric acid. Biotechnol Biofuels. 2018, 11.13, 23.
Li, J; Gu, S; Zhao, Z; Chen, B; Liu, Q; Sun, T; Sun, W; Tian, C* Dissecting cellobiose metabolic pathway and its application in biorefinery through consolidated bioprocessing in Myceliophthora thermophila. Fungal Biol Biotechnol. 2019, 6, 21.