生物医药

1. 合成生物学：
利用生物信息学和现代分子生物学方法手段构建高效细胞工厂，在生物医药、生物化工、生物能源等领域实现产品的高效合成。
2. 生物过程工程：
结合细胞的营养需求与产物代谢的特点，充分利用信息化、工程化的手段，实现规模化生物制造过程的可控、稳定与高效。

1. Yang, M., Zhou, X., Bao, Y., Zhang, Y., Liu, B., Gan, L., Tao, W., Tuo, J., and Gong, H., Comprehensive Genomic Analysis Reveals Extensive Diversity of Type I and Type IV Secretion Systems in Klebsiella pneumoniae. Curr Microbiol, 2023. 80(8): p. 270.
2. Zhang, Y., Yang, M., Bao, Y., Tao, W., Tuo, J., Liu, B., Gan, L., Fu, S., and Gong, H., A genome-scale metabolic model of the effect of dissolved oxygen on 1,3-propanediol fermentation by Klebsiella pneumoniae. Bioprocess Biosyst Eng, 2023.
3. Dong, S., Liu, X., Chen, T., Zhou, X., Li, S., Fu, S., and Gong, H., Mutation of rpoS is Beneficial for Suppressing Organic Acid Secretion During 1,3-Propandiol Biosynthesis in Klebsiella pneumoniae. Curr Microbiol, 2022. 79(8): p. 218.
4. Zhou, X., Chu, Q., Li, S., Yang, M., Bao, Y., Zhang, Y., Fu, S., and Gong, H., A new and effective genes-based method for phylogenetic analysis of Klebsiella pneumoniae. Infection, Genetics and Evolution, 2022. 100: p. 105275.
5.  Bao, W., Wei, R., Liu, X., Dong, S., Chen, T., Fu, S., and Gong, H., Regulation of Pyruvate Formate Lyase-Deficient Klebsiella pneumoniae for Efficient 1,3-Propanediol Bioproduction. Curr Microbiol, 2020. 77(1): p. 55-61.
6.  Xu, D., Jia, Z., Zhang, L., Fu, S., and Gong, H., Analysis of the Growth and Metabolites of a Pyruvate Dehydrogenase Complex- Deficient Klebsiella pneumoniae Mutant in a Glycerol-Based Medium. J Microbiol Biotechnol, 2020. 30(5): p. 753-761.
7. Zhang, L., Bao, W., Wei, R., Fu, S., and Gong, H., Inactivating NADH:quinone oxidoreductases affects the growth and metabolism of Klebsiella pneumoniae. Biotechnol Appl Biochem, 2018. 65(6): p. 857-864.
8.  Zhang, Y., Jia, Z., Lin, J., Xu, D., Fu, S., and Gong, H., Deleting pck improves growth and suppresses by-product formation during 1,3-propanediol fermentation by Klebsiella pneumoniae. J Appl Microbiol, 2017. 123(3): p. 678-687.
9. Huang, Y., Gu, J., Xiang, G., Xu, J., Fu, S., and Gong, H., Detection of total protein in milk using phosphomolybdic acid-mediated surface-enhanced Raman spectroscopy. Journal of Raman Spectroscopy, 2016. 47(3): p. 277-282.
10. Lin, J., Zhang, Y., Xu, D., Xiang, G., Jia, Z., Fu, S., and Gong, H., Deletion of poxB, pta, and ackA improves 1,3-propanediol production by Klebsiella pneumoniae. Appl Microbiol Biotechnol, 2016. 100(6): p. 2775-84.
11. Cui, Y.L., Zhou, J.J., Gao, L.R., Zhu, C.Q., Jiang, X., Fu, S.L., and Gong, H., Utilization of excess NADH in 2,3-butanediol-deficient Klebsiella pneumoniae for 1,3-propanediol production. J Appl Microbiol, 2014. 117(3): p. 690-8.
12. Gao, L.R., Jiang, X., Fu, S.L., and Gong, H., In silico identification of potential virulence genes in 1,3-propanediol producer Klebsiella pneumonia. J Biotechnol, 2014. 189(10): p. 9-14.
13. Zhong, Z.H., Liu, L.F., Zhou, J.J., Gao, L.R., Xu, J.J., Fu, S.L., and H., G. Influences of 3-hydroxypropionaldehyde and lactate on the production of 1,3-propanediol by Klebsiella pneumoniae. Bioresources and Bioprocessing, 2014. 1,  DOI: 10.1186/s40643-014-0002-z.
14. Xu, J., Turner, J.W., Idso, M., Biryukov, S.V., Rognstad, L., Gong, H., Trainer, V.L., Wells, M.L., Strom, M.S., and Yu, Q., In situ strain-level detection and identification of Vibrio parahaemolyticus using surface-enhanced Raman spectroscopy. Anal Chem, 2013. 85(5): p. 2630-7.
15. Zhang, L., Xu, J., Mi, L., Gong, H., Jiang, S., and Yu, Q., Multifunctional magnetic-plasmonic nanoparticles for fast concentration and sensitive detection of bacteria using SERS. Biosensors & Bioelectronics, 2012. 31(1): p. 130-6.
16. Xu, J., Kvasnicka, P., Idso, M., Jordan, R.W., Gong, H., Homola, J., and Yu, Q., Understanding the effects of dielectric medium, substrate, and depth on electric fields and SERS of quasi-3D plasmonic nanostructures. Opt Express, 2011. 19(21): p. 20493-505.
17. Xu, J., Zhang, L., Gong, H., Homola, J., and Yu, Q., Tailoring plasmonic nanostructures for optimal SERS sensing of small molecules and large microorganisms. Small, 2011. 7(3): p. 371-6.
18. Xu, J.J., Guan, P., Kvasnicka, P., Gong, H., Homola, J., and Yu, Q.M., Light Transmission and Surface-Enhanced Raman Scattering of Quasi-3D Plasmonic Nanostructure Arrays with Deep and Shallow Fabry-Perot Nanocavities. Journal of Physical Chemistry C, 2011. 115(22): p. 10996-11002.
19. Yu, Q., Braswell, S., Christin, B., Xu, J., Wallace, P.M., Gong, H., and Kaminsky, D., Surface-enhanced Raman scattering on gold quasi-3D nanostructure and 2D nanohole arrays. Nanotechnology, 2010. 21(35): p. 355301.