生物医药

健康与农业数字生物工程：
基于人工智能的生物活性分子高通量筛选及生物合成研究；
人体益生菌及农业益生菌的专利菌株发掘及菌剂配方理性设计研究；
基于结构生物学的食品酶学研究与酶制剂开发。

1. Zou Y, Ro K‑S, Jiang C, Yin D, Zhao·L, Zhang D, Du L*, Xie J. The anti‑hyperuricemic and gut microbiota regulatory effects of a novel purine assimilatory strain, Lactiplantibacillus plantarum X7022. European Journal of Nutrition. 2024 Apr, 63(3): 697-711

2. Gu S#, Yu J#, Du L, Zhang D, Zhao L, Xie J*. Characterization, semirational design for pH robustness, and the application in bioactive peptides production of a X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis MY-3.Journal of Agricultural and Food Chemistry. 2024 Mar, 72(13): 7279-7290

3. Wang Y, Xie D, Zhao L, Chen Z, Zhang Y, Du L*, Xie J*. Anti-hypertensive and gut microbiota regulatory effects of yeast protein hydrolysate on spontaneous hypertensive rat. Process Biochemistry. 2024 May, 140: 66-77

4. Luo J, Gu S, Zhu J, Ro K-S, Zhao L, Du L*, Xie J*, Wei D. Screening, cloning and expression of β-galactosidase from lactic acid bacteria and semi-rational design for the improvement of transgalactosylation activity. Process Biochemistry. 2024 May, 140: 19-31

5. Yin D#, Zhao L#, Deng S, Xie Y, Ro K-S, Yang Z, Du L*, Xie J*, Wei D. Lactiplantibacillus plantarum X7022 plays roles on aging mice with memory impairment induced by D‑galactose through restoring neuronal damage, relieving inflammation and oxidative stress.Probiotics and Antimicrobial Proteins. 2024 Jan.

6. Ro K-S#, Zhao L#, Hu Y, Ge M, Du L*, Xie J*. Anti-hyperuricemic properties and mechanism of Lactiplantibacillus plantarum X7023.Process Biochemistry. 2024 Jan. 136: 26-37.

7. Xie D, Shen Y, Su E, Du L*, Xie J*, Wei D. Anti-hyperuricemic, nephroprotective and gut microbiota regulative effects of separated hydrolysate of α-lactalbumin on potassium oxonate- and hypoxanthine-induced hyperuricemic mice. Molecular Nutrition & Food Research. 2023 Jan, 67: 2200162

8. Xie J*. The screening and prediction of functional/bioactive compounds in foods: Editorial; how to efficiently discover functional/bioactive compounds in foods? Food Science & Nutrition. 2023 May, 11: 2254–2255.

9. Xie X, Ro K, Hu Y, Du L, Zhao L*, Xie J*, Wei D. A novel γ-aminobutyric acid biosynthetic pathway in Lentilactobacillus curieae CCTCC M 2011381 T. Process Biochemistry. 2023 Jan, 124: 160-167.

10. Chen X, LiuG, Zhao L, Du L*, Xie J*, WeiD. Lactiplantibacillus plantarum X7022 ameliorates loperamide induced constipation and modulates gut microbiota in mice. Food Bioengineering. 2022, 1(3-4): 252-263.

11. Jiang C, Liu Y, Wang Y, Su E, Du L*, Tang Y-J, Xie J*, Wei D. Hypolipidemic effects of the fermented soymilk with a novel Lactiplantibacillus plantarum strain X7021 on mice via modulating lipid metabolism and gut microbiota. International Journal of Food Science and Technology. 2022 Jul, 57(7): 4555-4565

12. Zhao L, Zhu J, Xie J*, Wei D*. Discovery of a novel acrylic acid formation pathway in Gluconobacter oxydans and its application in biosynthesis of acrylic acid from glycerol. Process Biochemistry. 2022 Apr, 118: 182-189

13. Ro K-S, Chen Y, Du L, Wang L, Zhao L*, Xie J*, Wei D. Improvement of S-allylcysteine content, probiotic properties and 1 constipation prevention effect of black garlic by the lactic acid bacteria fermentation. Process Biochemistry. 2022, 115: 110-117

14. Du L, Ro K-S, Zhang Y, Tang Y-J, Li Wan, Xie J*, Wei D*. Effects of Lactiplantibacillus plantarum X7021 on physicochemical properties, purines, isoflavones and volatile compounds of fermented soymilk. Process Biochemistry. 2022, 113: 150-157

15. Xie D, Shen Y, Su E, Du L, Xie J*, Wei D*. The effects of angiotensin I-converting enzyme inhibitory peptide VGINYW and the hydrolysate of α-lactalbumin on blood pressure, oxidative stress and gut microbiota of spontaneously hypertensive rats. Food & Function. 2022, 13: 2743-2755

16. Xie D, Du L, Lin H, Su E, Shen Y, Xie J*, Wei D*. In vitro-in silico screening strategy and mechanism of angiotensin I-converting enzyme inhibitory peptides from α-lactalbumin. Lebensmittel-Wissenschaft und-Technologie. 2022, 156: 112984

17. Liu G, Liu Y, Ro K-S, Du L, Tang Y-J, Zhao L*, Xie J, Wei D. Genomic characteristics of a novel strain Lactiplantibacillus plantarum X7021 isolated from the brine of stinky tofu for the application in food fermentation. Lebensmittel-Wissenschaft und-Technologie. 2022, 156: 113054

1.  谢静莉，汪立新，魏东芝，陈颖. 一种植物乳杆菌X7022的应用. 黑蒜酵素及其制备方法与应用. 2021.6.29. 中国. ZL201910749499.9
2.  谢静莉，陈绪军，朱巧莎，吴俊杰，周琰，魏东芝. 降血压肽和降血压蛋白质及其应用. 2022.8.5 中国，ZL 201910338676.4
3.  谢静莉，魏东芝，李立. 发酵剂、臭豆腐卤液的直投式发酵方法及臭豆腐卤液. 2022.6.1 中国，ZL 202010455797.X
4.  谢静莉，陈绪军，朱巧莎，吴俊杰，周琰，魏东芝. 降血压肽和降血压蛋白质及其应用. 2022.8.5 中国，ZL 201910339075.5
5.  谢静莉，魏东芝，刘广. 植物乳杆菌X7022在预防和治疗便秘上的应用. 202110928783.X
6.  谢静莉，魏东芝，谢德伟. α-乳白蛋白水解液和降血压肽及其应用. 202110289201.8
7.  谢静莉，魏东芝，谢德伟，方明，马长宏. alpha-乳白蛋白小分子量水解物，其制备方法和降尿酸的应用. 202110836004.

先后作为课题组长或负责人承担科技部863计划、国家自然科学基金青年基金项目、上海市科技攻关项目子课题。参与科技部重点研发计划、973计划项等多项国家及省部级课题。与雀巢上海研发有限公司、美国派拉蒙农场有限公司、赢创（上海）投资管理有限公司，资生堂（中国）投资管理有限公司，澳大利亚长青食品有限公司；安琪纽特股份有限公司，上海清美绿色食品集团，上海汉康豆类食品有限公司等多家国内外企业合作新产品和新技术开发。

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