生物医药

基于分离提取技术的食品药品及材料工程。
主要研究兴趣：
1, 分离工程（膜及色谱分离技术）；
2, 糖生物工程（功能碳水化合物的生物制造、分离纯化及功能评价）；
3, 生物基材料工程（生物基材料开发及其在食品医药纺织等领域领域应用）；
4，特殊医学用途全营养食品、发酵食品开发。

1. Ran Zhang, Yuyan Tang, Xiangru Feng, Xiaoxuan Lu, Mengyao Zhao, Jiayang Jin, Xiaoguo Ji*, Haidong He*, Liming Zhao*. Targeted modulation of intestinal barrier and mucosal immune-related microbiota attenuates IgA nephropathy progression. Gut Microbes, 2025,17(1),2458184.
2. Zhang Yayu#, Ji Xiaoguo#, Chang Kunlin, Yin Hao, Zhao Mengyao*, Zhao Liming*. The regulatory effect of chitooligosaccharides on islet inflammation in T2D individuals after islet cell transplantation: the mechanism behind Candida albicans abundance and macrophage polarization. Gut Microbes, 2025, 17(1), 2442051.
3. Qiong Zhao, Liqiang Fan, Yanan Cui, Mengxuan Zhao, Chen Deng*, Liming Zhao*，Isolation and Identification of a Novel Chitinilyticum sp.C8: Unleashing the Potential for Chitin Oligosaccharides Production，Journal of Agricultural and Food Chemistry，2025
4. Chen Deng, Ruijie Xin, Xingjian Li, Jie Zhang, Liqiang Fan, Yongjun Qiu, Liming Zhao*, Optogenetic control of Corynebacterium glutamicum gene expression, Nucleic Acids Research, 2024, 52, 14260–14276.
5. Tosin Michael Olajide#, Zhennan Zhu#, Tong Li, Lidan Shu, Honghui Cao, Yong Wang, Liming Zhao*, Wenming Cao*, Profiling of FAHFAs in edible oils by chemical isotope labeling-assisted LC-MS: Impact of refining on FAHFA levels in rice bran oil, Food Research International,203,2025,115897.
6. Dongqing Guan, Xue Yang, Jiamian Tao, Fangke Zhan, Yongjun Qiu, Jiayang Jin*, Liming Zhao*, Novel biodegradable polyamide 4/chitosan casing films for enhanced fermented sausage packaging, Food Packaging and Shelf Life, 47,2025,101444
7. Mingda Wang, Yajing Zhang, Fangke Zhan, Yongjun Qiu, Tao Chen*, Liming Zhao*, Kinetic analysis of PA4 thermal degradation: Thermal stability with respect to crystallinity, Polymer Degradation and Stability, 227,2024,110880.
8. Rujun Zhou, Jiancai Zhu, Yunwei Niu, Jing Zhang, Zuobing Xiao*, Liming Zhao*, Identification of characteristic compounds of sweet orange oil and their sweetening effects on the sucrose solution with sweetness meter, sensory analysis, electronic tongue, and molecular dynamics simulation, Food Chemistry, 461,2024,140815.
9. Jinqi Shi, Chen Deng, Chunyue Zhang, Shu Quan, Liqiang Fan*, Liming Zhao*, Combinatorial metabolic engineering of Escherichia coli for de novo production of structurally defined and homogeneous Amino oligosaccharides, Synthetic and Systems Biotechnology, 2024,9(4): 713-722.
10. Jiayang Jin, Linrong Shen, Xu Ye, Jiahui Wang, Richard W. Hartel*, Liming Zhao*, Effects of surface modification of sucrose particles on chocolate morphology and fat bloom during storage, Journal of Food Engineering, 379,2024,112125.
11. Fangke Zhan#, Ziying Wang#, Junyu Shi, Di Zhang, Mingda Wang, Zhenwei Yi, and Liming Zhao*,Biodegradable Polybutyrolactam Microfiber Membrane as a Highly Efficient Air Filter for PM2.5 Particle Filtration, ACS Applied Polymer Materials, 2024 6 (2), 1215-1223.
12. Yuan Li, Jiaqi Zou, Hao Yin, Mengyao Zhao*, Liming Zhao*, The Preventative Effect of Chitooligosaccharides against Chronic Alcoholic Liver Disease by Regulating Alcohol Metabolism, Fatty Acid Metabolism, and Intestinal Barrier Damage, Journal of Food Biochemistry, 2024, 1323706.
13. Ying Yang#, Shuqin Wang, Xingyan Liu, Wenbin Zhang, Wenhua Tong*#, Huibo Luo, Liming Zhao*, Interactions of ferulic acid and ferulic acid methyl ester with endogenous proteins: etermination using the multi-methods, Heliyon, 10(2), 2024,e24605.
14. Wang Mingda, Zhang Yajing, Zhan Fangke, Qiu Yongjun, Chen Tao, Zhao Liming*, Crystallization behaviour of polyamide 4 and its effect on melting point, Polymer. 291 (2024) 126613.
15. Zhenwei Yi, Fangke Zhan, Yijia Chen, Ran Zhang, Haodong Lin*, Liming Zhao*, An electroconductive hydrogel with injectable and self-healing properties accelerates peripheral nerve regeneration and motor functional recovery, Chemical Engineering Journal, 478(2023):147261.
16. Xingxing Zhang, Lujie Liu, Chunyue Zhang, Yuechao Zhu, Hefei Zhao, Liming Zhao*, Adsorption mechanisms of alginate oligosaccharides with specific degree of polymerizations on a novel ion-exchange resin: experiments and simulations, Chemical Engineering Journal,460, 2023, 141717
17. Yanan Cui#, Chen Deng#, Liqiang Fan, Yongjun Qiu, Liming Zhao *，Progress in the biosynthesis of bio-based PET and PEF polyester monomers，Green Chemistry，2023, 25, 5836 – 5857.
18. Li Wang#, Ziwei Zhang#, Di Zhang, Yongjun Qiu, Yibing Wang, Shu Quan, Liming Zhao*, Exploring microbial degradation of polyamide 4 in soils: Unveiling degradation mechanisms, pathways, and the contribution of strain NR4, Journal of Cleaner Production, 429(2023):139535.
19. Xingxing Zhang, Lujie Liu, Banghe Jiang, Hefei Zhao, Liming Zhao*, Efficient adsorption of alginate oligosaccharides by ion exchange resin based on molecular simulation and experiments, Separation and Purification Technology,17 (2023) 123942
20. Chen Deng, Mengxuan Zhao, Qiong Zhao，Liming Zhao*，Advances in green bioproduction of marine and glycosaminoglycan oligosaccharides，Carbohydrate Polymers，300（2023）, 120254.
21. Mingda Wang, Yongjun Qiu,Tao Chen, Liming Zhao*,The catalytic mechanism and limiting factor of polyamide hydrolysis for chemical recycling: the classic hydrolysis of polyamide 4. Journal of Polymer Research, (2023) 30:186
22. Xu Ye#, Jiayang Jin#, Caiyan Liang, Jiahui Wang, Lihua Jiang*, Liming Zhao*, Effects of individual phospholipids on chocolate model systems: Particulate interaction, crystallization behavior, and fat bloom during storage, Journal of Food Engineering, 357(2023):111618,
23. Di Zhang, Fangke Zhan, Ziying Wang, Li Wang, Yongjun Qiu, Tao Chen, Yibing Wang*, Liming Zhao*, Development of Biodegradable Polyamide 4/Polyvinyl Alcohol/Poly(lactic acid) Multilayer Films with Tunable Water Barrier Property and Superior Oxygen Barrier Property, ACS Applied Polymer Materials, 2023, 5 (6): 3979-3988
24. Zhuoyu Li#, Mengyao Zhao#, Xiaoguo Ji, Liqiang Fan*, Liming Zhao*, Alginate oligosaccharides improve high-fat induced hepatic steatosis via PGC-1α-mediated lipophagy and fatty acid β-oxidation pathway, Journal of Functional Foods,110(2023),105825.
25. Xinye Zhuang#, Mengyao Zhao#, Xiaoguo Ji, Sihan Yang, Hao Yin* , Liming Zhao*. Chitobiose exhibited a lipid-lowering effect in ob/ob−/− mice via butyric acid enrolled liver–gut crosstalk. Bioresources and Bioprocessing, (2023) 10:79.
26. Yajing Zhang, Mingda Wang, Liquan Wang, Tao Chen, Weisheng Feng,Tianyi Wang, Liming Zhao*. Molecular dynamics simulation and non-isothermal crystallization kinetics of polyamide 4 and different bio-based polyamide blends. Physical Chemistry Chemical Physics, 2023, 25, 25309-25321.
27. Wenhua Tong*, Yiyun Li, Zhijiu Huang, Shuqin Wang, Guanying Chen, Xingyan Liu, Ying Yang, Liming Zhao*, Mechanism of molecular interaction between pyrazine flavor substances and Lysozyme: Based on spectroscopy and molecular docking studies, Journal of Molecular Liquids, 389（2023）,122876.
28. Qiao Lv#, Lujie Liu#, Yanying Hou, Hefei Zhao, Liming Zhao*, Insight of chitooligosaccharides diffusion within polymeric membranes using molecular dynamic simulation, Journal of Molecular Liquids, 389（2023）,122734.
29. Ziying Wang#, Fangke Zhan#, Di Zhang, Yibing Wang, Yongjun Qiu, Jie Zhang, Li Wang*, Liming Zhao*, Relative humidity-triggered polyamide 4/ Cinnamaldehyde core-shell nanofibers for antibacterial packaging. Journal of Food Engineering. 357 (2023) 11163.
30. Yajing Zhang, Mingda Wang, Di Zhang, Yibing Wang, Li Wang, Yongjun Qiu, Liquan Wang, Tao Chen*, Liming Zhao*. Crystallization and performance of polyamide blends comprising polyamide 4, polyamide 6, and their copolymers. Polymers, 2023, 15(16): 3399.
31. Yu Wang#, Xiaoguo Ji#, Mengyao Zhao, Juan Li, Hao Yin, Jiayang Jin*, Liming Zhao*, Modulation of tryptophan metabolism via AHR-IL22 pathway mediates the alleviation of DSS-induced colitis by chitooligosaccharides with different degrees of polymerization, Carbohydrate Polymers,319（2023）,121180.
32. Boya Zhang, Mengyao Zhao*, Xiaoguo Ji, Quanming Xia, Lihua Jiang, Liming Zhao*, Acrylamide induces neurotoxicity in zebrafish (Danio rerio) via NLRP3-mediated pyroptosis, Science of The Total Environment, 896,2023,165208.
33. Qiong Zhao, Liqiang Fan, Chen Deng, Chunyu Ma, Chunyue Zhang*, Liming Zhao*, Bioconversion of chitin into chitin oligosaccharides using a novel chitinase with high chitin-binding capacity, International Journal of Biological Macromolecules, 244（2023）125241.
34. Chunyu Ma#, Chunyue Zhang#, Liqiang Fan, Chen Deng*, Liming Zhao*,De novo 2′-fucosyllactose bioproduction through modular engineering of a novel Escherichia coli K12-derived strain, Food Bioengineering, 2023,2(2):89-104
35. Difan Qian#, Chunyue Zhang#, Chen Deng, Mian Zhou, Liqiang Fan*, Liming Zhao*. De novo biosynthesis of 2’-fucosyllactose in engineered Pichia pastoris. Biotechnol Lett, 45(2023):521–536.
36. 王乾， 赵黎明*，姜黄素调节LKB1-AMPK-LC3信号通路对膀胱癌细胞增殖、迁移和顺铂耐药性的影响[J]，细胞与分子免疫学杂志，2025，41（1）.
37. 衣振伟, 林浩东*, 赵黎明*. 壳聚糖支架在周围神经修复中的应用研究进展[J]. 功能高分子学报，2024，37（3）：251-261.
38. 蔡天航，吕冠锋，陈涛*，赵黎明*．低共熔溶剂改性聚丁内酰胺的结晶性能[J/OL]．功能高分子学报.  2024 ,37 (05).
39. 刘鲁杰，王刚，赵黎明*，黄世慧，秦建国，凌芳．膜分离技术在低分子糖类辅料制备中的应用[J/OL]．化学试剂. 2024，46（9）.
40. 刘硕，刘鲁杰，王永红，赵黎明．响应面法优化N-乙酰氨基葡萄糖发酵液精制纯化工艺[J/OL]．化学试剂. 2023，45(7) :1-9.
41. 郭佩，赵黎明*，刘鲁杰，邱勇隽，李爽．利用纳滤膜技术分离秸秆发酵液中糖和乳酸的研究[J/OL]．膜科学与技术. 2023，43（3）：104-115.
42. 王刚，刘鲁杰，秦建国，赵黎明*．新型分离纯化技术在药用蔗糖制备工艺中的应用[J/OL]．化学试剂. 2023，45(7) : 10-16.
43. 明远，陈涛*，赵黎明*，邱勇隽．聚己内酯/聚丁内酰胺电纺纤维的制备及性能[J]．功能高分子学报. 2023，36（2）：160-169
44. 刘倩，袁越，张杰，赵瑞丽，赵黎明*. 不同菌种发酵对诺丽果酵素的抗氧化性及风味物质的影响 [J]. 食品工业科技，2023，44（4）：129−137.

1，主持国家重点研发计划项目：（2022YFC2104500）。
2，主持国家重点研发计划课题：（2019YFD0901805）(已结题)。
3，主持国家重点研发计划课题：（2017YFB0309302）(已结题)。
4，主持国家高技术研究发展计划（863）课题：（2014AA021202）(已结题)。
5，主持工信部绿色制造系统集成项目：氨基葡萄糖生产绿色关键技术开发与系统集成项目(已结题)。
6，主持国家自然科学基金项目：甲壳素加工废水纳滤传质机理/膜分离特性和污染机理研究(已结题)。
7，主持国家自然科学基金项目：纳滤分离中单糖分子结构、极性和计算分子直径对分离和传质特性的影响和机理研究(已结题)。