论文著作：
[1] You ZN, Zhou K, Han Y, Yang BY, Chen Q, Pan J, Qian XL, Li CX*, Xu JH* (2021). Design of a self-sufficient hydride-shuttling cascade for concurrent bioproduction of 7,12-dioxolithocholate and L-tert-leucine. Green Chem., 2021,23, 4125–4133.
[2] Zhan JR, Shou C, Zheng YC, Chen Q, Pan J, Li CX*, Xu JH* (2021). Discovery and engineering of bacterial (-)-isopiperitenol dehydrogenases to enhance (-)-menthol precursor biosynthesis. Adv. Synth. Catal., doi.org/10.1002/adsc.202100368.
[3] Zhang GX,# You ZN,# Yu JM, Liu YY, Pan J, Xu JH*, Li CX*(2021). Discovery and engineering of a novel Baeyer-Villiger monooxygenase with high normal regioselectivity. ChemBioChem2021, 22, 1190–1195.
[4] You ZN,# Qi Chen,# Shi SC, Zheng MM, Pan J, Qian XL, Li CX*, and Xu JH* (2019). Switching cofactor dependence of 7β-hydroxysteroid dehydrogenase for cost-effective production of ursodeoxycholic acid. ACS Catal., 2019, 9, 466–473.
[5] Shi SC,# You ZN,# Zhou K, Chen Q, Pan J, Qian XL, Xu JH*, Li CX* (2019). Efficient synthesis of 12-oxochenodeoxycholic acid using a 12α-hydroxysteroid dehydrogenase from Rhodococcus ruber. Adv. Synth. Catal. 2019, 361, 4661–4668.
[6] Zheng MM, Chen FF, Li H, Li CX*, and Xu JH* (2018). Continuous production of ursodeoxycholic acid by using two cascade reactors with co-immobilized enzymes. ChemBioChem, 2018, 19, 347–353.
[7] Zheng MM, Chen KC, Wang RF, Li H, Li CX*, and Xu JH* (2017). Engineering 7β-hydroxysteroid dehydrogenase for enhanced ursodeoxycholic acid production by multiobjective directed evolution. J. Agric. Food Chem., 65: 1178−1185.
[8] Chen KC, Zheng MM, Pan J, LiCX*, Xu JH* (2017). Protein engineering and homologous expression of Serratia marcescens Lipase for efficient synthesis of a pharmaceutically relevant chiral epoxyester. Appl Biochem Biotechnol., 183:543–554
[9] Jiang Y, Shang YP, Li H, Zhang C, Pan J, Bai YP, Li CX* and Xu JH* (2017). Enhancing transglutaminase production of Streptomyces mobaraensis by iterative mutagenesis breeding with atmospheric and room-temperature plasma (ARTP). Bioresour. Bioprocess. 4:37
[10] Liu XY, Chen FF, Li CX∗, Xiao-Jing Luo, Qi Chen, Yun-Peng Bai, Jian-He Xu (2016).Improved efficiency of a novel methyl parathion hydrolase using consensus approach. Enzyme Microb. Tech., 93-94,11–17
[11] Yi Gong, Guo-Chao Xu, Qi Chen, Jin-Gang Yin, Chun-Xiu Li* and Jian -He Xu* (2016). Iterative Multitarget Evolution Dramatically Enhances the Enantioselectivity and Catalytic Efficiency of Bacillus subtilis Esterase towards Bulky Benzoate Ester of dl-Menthol. Catal. Sci. Technol., 6, 2370–2376
[12] Li CX, Jiang XC, Qiu YJ, Xu JH* (2015). Identification of a new thermo- and alkaline-tolerant α-carbonic anhydrase from Lactobacillus delbrueckii: Performance in CO2 biomineralization into vaterite. Bioresources and Bioprocessing, 2: 44
[13] Du FL, Yu HL, Xu JH, Li CX*(2014). Enhanced limonene production by optimizing the expression of limonene biosynthesis and MEP pathway genes in E. coli Bioresources and Bioprocessing, 1: 10.
[14] Gong Y, Xu GC, Li CX*, Zheng GW, Xu JH* (2014). A thermostable variant of Bacillus subtilis esterase: characterization and application for resolving dl-menthyl acetate. J. Mol. Catal. B: Enzym. 109, 1-8.
[15] Hu K, Li CX*, Pan J, Ni Y, Zhang XY, Xu JH* (2014). Performance of a new thermostable mannanase in breaking guar-based fracturing fluids at high temperatures with little premature degradation. Appl. Biochem. Biotechnol., 172, 1215-1226.
[16] Wang LJ, Li CX*, Ni Y, Zhang J, Liu X, Xu JH* (2011). Highly efficient synthesis of chiral alcohols with a novel NADH-dependent reductase from Streptomyces coelicolor. Bioresour. Technol., 102, 7023–7028
[17] Ni Y, Li CX*, Zhang J, Shen ND, Bornscheuer UT, Xu JH* (2011). Efficient reduction of ethyl 2-oxo-4-phenylbutyrate at 620 g/L-1 by a bacterial reductase with broad substrate spectrum. Adv. Synth. Catal., 353, 1213–1217.
[18] Ni Y, Li CX*, Ma HM, Xu JH* (2011). Biocatalytic properties of a recombinant aldo-keto reductase with broad substrate spectrum and excellent stereoselectivity. Appl. Microbiol. Biotechnol., 89, 1111–1118.
[19] Ni Y, Li CX*, Wang LJ, Zhang J, Xu JH* (2011). Highly stereoselective reduction of prochiral ketones by a bacterial reductase coupled with cofactor regeneration. Org. Biomol. Chem., 9, 5463–5468.
[20] Qiu, LH, Li CX*, Sun J, Xu JH* (2011). Thermostable bacterial endoglucanases mined from Swiss-Prot database. Appl. Biochem. Biotechnol. 165, 1473–1484.
李春秀
上海市
研究领域：
精细化工,生物医药
研究方向：
1）新酶的挖掘改造与催化机制研究
2）天然产物的生物合成
所在单位：
华东理工大学
