生物医药

1. 细胞代谢工程及系统生物技术开发
2. 微生物细胞工厂构建及代谢工程改造
3. 细胞代谢反应网络模型的开发及应用

1. Qi Gao, Jing-Lin Yang, Xin-Ru Zhao, Zhi-Jie Liu, Liu-Jing Wei*, Qiang Hua*. Yarrowia lipolytica as a metabolic engineering platform for the production of very-long-chain wax esters. Journal of Agricultural and Food Chemistry, 68:10730-10740, 2020.
2. Shun-Cheng Liu, Zhijie Liu, Liu-Jing Wei*, Qiang Hua*. Pathway engineering and medium optimization for α-farnesene biosynthesis in oleaginous yeast Yarrowia lipolytica. Journal of Biotechnology, 319:74-81, 2020.
3. Ting Liu, Ziwen Jin, Ziwei Wang, Jun Chen, Liu-Jing Wei, Qiang Hua*. Metabolomics analysis of Actinosynnema pretiosum with improved AP-3 production by enhancing UDP-glucose biosynthesis. Journal of Bioscience and Bioengineering, 130(1):36-47, 2020.
4. Xin-Kai Zhang, Dan-Ni Wang, Jun Chen, Liu-Jing Wei, Qiang Hua*. Metabolic engineering of β-carotene biosynthesis in Yarrowia lipolytica. Biotechnology Letters, 42:945-956, 2020.
5. Ting Liu, Linbing Yang, Jun Chen, Fengxian Hu, Liu-Jing Wei, Qiang Hua*. Metabolomic change and pathway profiling reveal enhanced ansamitocin P-3 production in Actinosynnema pretiosum with low organic nitrogen availability in culture medium. Applied Microbiology and Biotechnology, 104:3555-3568, 2020.
6. Feng Liu, Junwen Mao, Ting Lu*, Qiang Hua*. Synthetic, context-dependent microbial consortium of predator and prey. ACS Synthetic Biology, 8(8):1713-1722, 2019.
7. Xin-Kai Zhang, Ming-Yue Nie, Jun Chen, Liu-Jing Wei, Qiang Hua*. Multicopy integrants ofcrtgenes and co-expression of AMP deaminase improve lycopene production in Yarrowia lipolytica. Journal of Biotechnology, 289:46-54, 2019.
8. Qi Gao, Xuan Cao, Yu-Ying Huang, Jing-Lin Yang, Jun Chen, Liu-Jing Wei*, Qiang Hua*. Overproduction of fatty acid ethyl esters by the oleaginous yeast Yarrowia lipolytica through metabolic engineering and process optimization. ACS Synthetic Biology, 7(5):1371-1380, 2018.
9. Deqing Gu, Xingxing Jian, Cheng Zhang, Qiang Hua*. Reframed genome-scale metabolic model to facilitate genetic design and integration with expression data. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 14(6):1410-1418, 2017.
10. Xuan Cao, Liu-Jing Wei, Jia-Yu Lin, Qiang Hua*. Enhancing linalool production by engineering oleaginous yeast Yarrowia lipolytica. Bioresource Technology, 245(B):1641-1644, 2017.
11. Xingxing Jian, Ningchuan Li, Qian Chen, Qiang Hua*. Model-guided identification of novel gene amplification targets for improving succinate production in Escherichia coli NZN111. Integrative Biology, 9:830-835, 2017.
12. Chen Zhao, Qi Gao, Jun Chen, Liujing Wei, Tadayuki Imanaka, Qiang Hua*. Metabolomic changes and metabolic responses to expression of heterologous biosynthetic genes for lycopene production in Yarrowia lipolytica. Journal of Biotechnology, 251(3):174-185, 2017.
13. Xuan Cao, Yu-Bei Lv, Jun Chen, Liu-Jing Wei*, Qiang Hua*. Metabolic engineering of oleaginous yeast Yarrowia lipolytica for limonene overproduction. Biotechnology for Biofuels, 9:214, 2016.
14. Xingxing Jian, Shengguo Zhou, Cheng Zhang, Qiang Hua*. In silico identification of gene amplification targets based on analysis of production and growth coupling. Biosystems, 145:1-8, 2016.
15. Cheng Zhang, Sunjae Lee, Adil Mardinoglu*, Qiang Hua*. Investigating the combinatory effects of biological networks on gene co-expression. Frontiers in Physiology, 7:160, 2016.
16. Yuxiang Fan, Mengjiang Zhao, Liujing Wei, Fengxian Hu, Tadayuki Imanak, Linquan Bai, Qiang Hua*. Enhancement of UDPG synthetic pathway improves ansamitocin production in Actinosynnema pretiosum. Applied Microbiology and Biotechnology, 100:2651-2662, 2016.

一种产脂肪酸乙酯的解脂耶氏酵母基因工程菌及其应用。发明人：花强，韦柳静，高琪，曹选，陈骏。授权号：ZL20161081886.7。

1. 国家重点研发计划政府间国际科技创新合作重点专项“结合代谢流量模拟及代谢工程改造增强解脂耶氏酵母的赤藓糖醇生产能力”
2. 国家自然科学基金面上项目“系统开发代谢网络模型及预测算法促进解脂耶氏酵母油脂合成的改造提高”
3. 国家自然科学基金面上项目“解脂耶氏酵母合成虾青素的系统代谢工程研究”

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