鲍杰 教授 博士 上海市 研究领域: 生物医药 研究方向: 1. 纤维素生物质合成聚乳酸等生物聚合物、生物航煤等液体燃料的工程微生物细胞工厂合成生物学; 2. 超级生物炼制微生物的发现、进化、代谢工程改造,以及工程化底盘微生物合成关键生物基产品; 3. 先进生物炼制过程工程及其计算机模拟。 所在单位: 华东理工大学

基本信息

传真:
021****51799
所在单位:
华东理工大学
机构细分:
生物工程学院
单位类型:
高等院校
职务:
教授
职称:
教授
最高学历:
博士
专家介绍:
鲍杰,工学博士,教授、博士生导师。南京理工大学获学士学位、浙江大学获硕士学位、日本国立山口大学获博士学位。2006年至今任职华东理工大学生物工程学院和生物反应器工程全国重点实验室。作为课题负责人主持科研项目数十项。现任SCI期刊Applied Biochemistry and Biotechnology高级编辑、Bioprocess and Biosystems Engineering副主编、ACS Sustainable Chemistry and Engineering编委、Springer和Elsevier学术期刊客座编辑,亚洲生物技术联合会生物能源与生物炼制分会理事。

其研究领域聚焦于生物炼制过程技术和工程微生物研究。提出的木质纤维素类淀粉化干法炼制技术,显示了巨大的技术优势和环境友好性,奠定了可持续碳中和生产聚合物和液体燃料的技术基础;生物炼制菌株的代谢工程和合成生物学改造,成倍提高了生物转化和发酵效率,达到了迄今国内外最高水平的生物炼制转化、能耗和排放指标。

科研能力

研究领域:
生物医药
研究方向:
1. 纤维素生物质合成聚乳酸等生物聚合物、生物航煤等液体燃料的工程微生物细胞工厂合成生物学;
2. 超级生物炼制微生物的发现、进化、代谢工程改造,以及工程化底盘微生物合成关键生物基产品;
3. 先进生物炼制过程工程及其计算机模拟。
论文著作:
1. Zhibin Li, Lingxiao Zhang, Bin Zhang, Jie Bao*. pH shifting adaptive evolution stimulates the low pH tolerance of Pediococcus acidilactici and high L-lactic acid fermentation efficiency. Bioresource Technology, 2025, 416, 131813
2.  Xiaomeng Guo, Zhibin Li, Niling He, Bin Zhang, Xiucai Liu, Jie Bao*. Detection and elimination of trace p-lactic acid in lignocellulose biorefining chain: Generation, flow, and impact on chiral lactide synthesis. Biotechnology and Bioengineering, 2024, 121, 670-682.
3. Agustian Chen, Bin Zhang, Jie Bao*. Adaptive evolution of Paecilomyces variotii enhanced the biodetoxification of high-titer inhibitors in pretreated lignocellulosic feedstock. Bioresource Technology, 2024, 411: 131351.
4.  Bin Zhang, Qingmei Han, Qi Liu, Ya Wang, Jie Bao*. Recycling of waste calcium carbonate in lignocellulosic biorefining chain for chiral lactic acid production. Bioresource Technology, 2024, 395,130303.
5. Bin Zhang, Xiucai Liu, Jie Bao*. High solids loading pretreatment: The core of lignocellulose biorefinery as an industrial technology – An overview. Bioresource Technology, 2023, 369:128334.
6.  Niling He, Jia Jia, Zhongyang Qiu, Chun Fang, Gunnar Lidén, Xiucai Liu, Jie Bao*. Cyclic L-lactide synthesis from lignocellulose biomass by biorefining with complete inhibitor removal and highly simultaneous sugars assimilation. Biotechnology and Bioengineering, 2022, 119:1903-1915. (Cover Image)
7.  Ci Jin, Jing Li, Zhen Huang, Xushen Han, Jie Bao*. Engineering Corynebacterium glutamicum for synthesis of poly(3-hydroxybutyrate) from lignocellulose biomass. Biotechnology and Bioengineering, 2022, 119:1598-1613.
8.  Qi Liu, Mingping Lu, Ci Jin, Weiliang Hou, Liao Zhao, Jie Bao*. Ultra-centrifugation force in adaptive evolution changes the cell structure of oleaginous yeast Trichosporon cutaneumin to a favorable space for lipid accumulation. Biotechnology and Bioengineering, 2022, 119:1509-1521.
9.  Ying-Ying Xu, Ke-Jun Hua, Zhen Huang, Ping-Ping Zhou, Jing-Bai Wen, Ci Jin, Jie Bao*. Cellulosic hydrocarbons production by engineering dual synthesis pathways in Corynebacterium glutamicum. Biotechnology for Biofuels and Bioproducts, 2022, 15:29.
10.  Bin Zhang, Jing Li, Xiucai Liu, Jie Bao*. Continuous simultaneous saccharification and co-fermentation (SSCF) for cellulosic L-lactic acid production. IndustrialCrops & Products, 2022, 187:115527.
11.  Bin Zhang, Faryal Ahemed, Baorui Zhan, Jie Bao*. Transformation of lignocellulose to starch‐like carbohydrates by organic acid-catalyzed pretreatment and biological detoxification. Biotechnology and Bioengineering, 2021, 118:4105-4118.
12.  Bin Zhang, Baorui Zhan, Jie Bao*. Reframing biorefinery processing chain of corn fiber for cellulosic ethanol production. Industrial Crops & Products, 2021, 170:113791.
13. Tao Han, Bin Zhang, Hongxing Li, Hongsen Zhang, Yongfu Yang, Lizhen Hu, Xiaodong Ren, Shipeng Wang, Lixiang Zheng, Xushen Han, Gang Liu, Jian Zhang, Qiang Fei, Yueqin Tang, Shihui Yang, Xiaoming Bao, Jie Bao*. Year-round storage operation of three major agricultural crop residue biomass by operating dry acid pretreatment at regional collection depots. ACS Sustainable Chemistry & Engineering, 2021, 9:4722-4739.
14. Ci Jin, Jie Bao*. Lysine production by dry biorefining of wheat straw and co-fermentation of Corynebacterium glutamicum. Journal of Agricultural and Food Chemistry, 2021, 69:1900-1906.
15. Zhao Yan, Jian Zhang, Jie Bao*. Increasing cellulosic ethanol production by enhancing phenolic tolerance of Zymomonas mobilis in adaptive evolution. Bioresource Technology, 2021, 329:124926.
16.  Ci Jin, Zhen Huang, Jie Bao*. High-titer glutamic acid production from lignocellulose using an engineered Corynebacterium glutamicum with simultaneous coutilization of xylose and glucose. ACS Sustainable Chemistry & Engineering, 2020, 8:6315-6322.
17.  Zhongyang Qiu, Chun Fang, Qiuqiang Gao, Jie Bao*. A short-chain dehydrogenase plays a key role in cellulosic D-lactic acid fermentability of Pediococcus acidilactici. Bioresource Technology, 2020, 297:122473.
18. Niling He, Chun Fang, Zhongyang Qiu, Jie Bao*. Increasing sodium lactate production by enhancement of Na+ transmembrane transportation in Pediococcus acidilactici. Bioresource Technology, 2020, 323:124562.
19. Lixiang Zheng, Xushen Han, Tao Han, Gang Liu, Jie Bao*. Formulating a fully converged biorefining chain with zero wastewater generation by recycling stillage liquid to dry acid pretreatment operation. Bioresource Technology, 2020, 318:124077.
20.  Zhao Yan, Xiaochuang Gao, Qiuqiang Gao, Jie Bao*. Mechanism of tolerance to the lignin-derived inhibitor p-benzoquinone and metabolic modification of biorefinery fermentation strains. Applied & Environmental Microbiology 2019, 85:e01443-19.
21.  Pingping Zhou, Ruimiao Yao, Hongsen Zhang, Jie Bao*. Unique glucose oxidation catalysis of Gluconobacter oxydans constitutes an efficient cellulosic gluconic acid fermentation free of inhibitory compounds disturbance. Biotechnology and Bioengineering, 2019, 116:2191-2199.
22.  Xia Yi, Qiuqiang Gao, Lei Zhang, Xia Wang, Yanqing He, Fengxian Hu, Jian Zhang, Gen Zou, Shihui Yang, Zhihua Zhou*, Jie Bao*. Heterozygous diploid structure of Amorphotheca resinae ZN1 contributes efficient biodetoxification on solid pretreated corn stover. Biotechnology for Biofuels, 2019, 12:126.
23.  Jingbai Wen, Jie Bao*. Engineering Corynebacterium glutamicum triggers glutamic acid accumulation in biotin rich corn stover hydrolysate. Biotechnology for Biofuels, 2019, 12:86.
24. Ci Jin, Weiliang Hou, Ruimiao Yao1, Pingping Zhou, Hongsen Zhang, Jie Bao*. Adaptive evolution of Gluconobacter oxydans accelerates the conversion rate of non-glucose sugars derived from lignocellulose biomass. Bioresource Technology, 2019, 289:121623.
25. Xushen Han, Li Li, Chengxiang Wei, Jian Zhang, Jie Bao*. Rich vitamins B in lignocellulose biomass facilitates L-lactic acid fermentation. Journal of Agricultural and Food Chemistry, 2019, 67:7082-7086.
科研项目:
木质纤维素生产手性乳酸的生物合成路径与抗逆机制研究(31961133006)、木质纤维素水解液体系中最轻油脂酵母细胞的全通量精准筛选(21978083)、复杂酶反应体系的抑制效应解析与关键路径的加速(20976051)、DNA扩增前提材料的生物合成与过程集成研究(20676037)
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