生物医药

生物分析及生物传感原理的创新，核酸探针设计等分析化学与生命科学交叉领域的基础与应用

1. Pin-Ru Chen, Pei-Pei Qin, Ya-Nan Wang, Peng-Fu Liu, Xin-Yue Zhang, Nan Deng, Tao Qian, Bang-Ce Ye*, and Bin-Cheng Yin*. De novo design of a compact transcript degrader by engineering Cas6-CBS system and substrate-specific toxins. Nature Communications, 16, 8446, 2025.
2. Pei-Pei Qin, Pin-Ru Chen, Liu Tan, Xiaohe Chu, Bang-Ce Ye, and Bin-Cheng Yin*. Programming ADAR-recruiting hairpin RNA sensor to detect endogenous molecules. Nucleic Acids Research 53 (1), gkae1146, 2025.
3. Hai-Yan Jia, Shu-Yu Yao, Ying-Fu Li, Bang-Ce Ye, Bin-Cheng Yin*. A Conformational Switch-Controlled RNA Sensor Based on Orthogonal dCas12a for RNA Imaging in Live Cells. Biosensors and Bioelectronics 273, 117185, 2025.
4. Yu-Ting Sun, Pei-Pei Qin, Bang-Ce Ye, and Bin-Cheng Yin*. Identification and Purification of Specific Cell Populations via ADAR-based Synthetic Genetic Circuits. ACS Synthetic Biology 2025.
5. Wen-Zhuo Sun, Xin Wang, Meng-Yu Fu, Le-Fan Liu, Ping Zhang, Bin-Cheng Yin, Weibing Liu, and Bang-Ce Ye. Metabolic Engineering of Yarrowia lipolytica for Enhanced De Novo Biosynthesis of Icaritin. ACS Synthetic Biology 14, 1142-1151, 2025.
6. Hai-Yan Jia, Xin-Yue Zhang, Bang-Ce Ye, Bin-Cheng Yin*. An Orthogonal CRISPR/dCas12a System for RNA Imaging in Live Cells. Analytical Chemistry 96 (15), 5913-5921, 2024.
7. Liu Tan, Bang-Ce Ye, Bin-Cheng Yin*. Research and application of engineered gRNA technology in CRISPR/Cas system. Chinese Journal of Biochemistry and Molecular Biology 40 (8), 1078-1092, 2024.
8. Wei Du, Shanshan Jiang, Shengxiang Yin, Rongjiang Wang, Chunling Zhang, Bin-Cheng Yin, Jialin Li, Li Li, Nan Qi, Ying Zhou, Bang-Ce Ye. The microbiota-dependent tryptophan metabolite alleviates high-fat diet-induced insulin resistance through the hepatic AhR/TSC2/mTORC1 axis. Proceedings of the National Academy of Sciences of the United States of America 121 (35), e2400385121, 2024
9. Li Zhao, Shi-Yu Zhou, Yu Fu, Jin-Long Shen, Bin-Cheng Yin, Di You*, Bang-Ce Ye*. A dual program for CRP-mediated regulation in bacterial alarmone (p)ppGpp. mBio. 15 (11), e0243024, 2024
10. Pei-Qiang Ma, Fu-Wen Huang, Ya-Qi Xie, Hong-Rui Li, Hua-Dong Li, Bang-Ce Ye, and Bin-Cheng Yin*. A Universal DNA-based Sensing Toolbox for Programming Cell Functions. Journal of the American Chemical Society 145 (51), 28224-28232, 2023.
11. Hua-Dong Li, Guan-Hua Fang, Bang-Ce Ye, and Bin-Cheng Yin*. RNase H-Driven crRNA Switch Circuits for Rapid and Sensitive Detection of Various Analytical Targets. Analytical Chemistry 95 (50), 18549-18556, 2023.
12. Jian Xiang, Bang-Ce Ye, and Bin-Cheng Yin*. Functionalized Exosomes Reprogram the Targeted Recognition Between Tumor Cells and Immune Cells. China Biotechnology 43(10), 1-9, 2023.
13. Hua-Dong Li, Pei-Qiang Ma, Jin-Yu Wang, Bin-Cheng Yin*, and Bang-Ce Ye*. A DNA Nanodevice-Based Platform with Diverse Capabilities. Small 2302301, 2023.
14. He-Hua Zhang, Jian Xiang, Bin-Cheng Yin*, and Bang-Ce Ye*. Overcoming multidrug resistance of cancer cells by base-editing-induced nonsense mutations. ACS Pharmacology & Translational Science 6 (5), 812-819, 2023.
15. Jin-Yu Wang, Hua-Dong Li, Pei-Qiang Ma, Ying Zhou, Bin-Cheng Yin*, and Bang-Ce Ye*. An miRISC-initiated DNA nanomachine for monitoring microRNA activity in living cells. Biosensors and Bioelectronics 220 (15), 114828, 2023.
16. Yu Fu, Yu-Qi Dong, Jin-Long Shen, Bin-Cheng Yin, Bang-Ce Ye, Di You. A meet-up of acetyl phosphate and c-di-GMP modulates BldD activity for development and antibiotic production. Nucleic Acids Research 51 (13), 6870-6882, 2023.
17. Pei-Qiang Ma, Tian-Xian Liu, Hua-Dong Li, Bin-Cheng Yin*, and Bang-Ce Ye*. Nano-Biohybrid DNA Engager That Reprograms the T-Cell Receptor. Journal of the American Chemical Society 144 (49), 22458-22469, 2022.
18. Peipei Qin, Pinru Chen, Nan Deng, Liu Tan, Bin-Cheng Yin*, and Bang-Ce Ye*. Switching the Activity of CRISPR/Cas12a Using an Allosteric Inhibitory Aptamer for Biosensing. Analytical Chemistry 94 (45), 15908-15914, 2022.
19. Ting Wang, Yan Wang, Pinru Chen, Bin-Cheng Yin*, and Bang-Ce Ye*. An Ultrasensitive, One-Pot RNA Detection Method Based on Rationally Engineered Cas9 Nickase-Assisted Isothermal Amplification Reaction. Analytical Chemistry, 94, 12461-12471, 2022.
20. Hai-Yan Jia, Hong-Li Zhao, Ting Wang, Pin-Ru Chen, Bin-Cheng Yin*, and Bang-Ce Ye. A Programmable and Sensitive CRISPR/Cas12a-based MicroRNA Detection Platform Combined with Hybridization Chain Reaction. Biosensors and Bioelectronics 211, 114382, 2022.
21. Pinru Chen, Luying Wang, Peipei Qin, Bin-Cheng Yin*, and Bang-Ce Ye*. An RNA-based catalytic hairpin assembly circuit coupled with CRISPR-Cas12a for one-step detection of microRNAs. Biosensors and Bioelectronics 207, 114152, 2022.
22. Li Zhao, Di You, Ting Wang, Zhen-Ping Zou, Bin-Cheng Yin*, Ying Zhou*, Bang-Ce Ye*. Acylation driven by intracellular metabolites in host cells inhibits Cas9 activity used for genome editing. PNAS Nexus 1, 1-8, 2022.
23. Shi-Fu Liang, Fang-Fang Zuo, Bin-Cheng Yin*, and Bang-Ce Ye*. Delivery of siRNA based on engineered exosomes for glioblastoma therapy by targeting STAT3. Biomaterials Science 10, 1582-1590, 2022.
24. Lu Wang, Meng-Li Cheng, Fang He, Jian Xiang, Bin-Cheng Yin*, Bang-Ce Ye. Clearance of Tumor Exosomes by Engineered Exosomes-Assisted Phagocytosis of Macrophages. China Biotechnology 42 (6), 1-11, 2022.
25. Yi-Lin Shen, Liu-Qing Zhang, Ying Yang, Bin-Cheng Yin, Bang-Ce Ye, Ying Zhou. Advances in the role and mechanism of lactic acid bacteria in treating obesity. Food Bioengineering 1, 101-115, 2022.