生物医药

蛋白质、多肽、多糖的生物基材料开发及在食品及医药领域的应用；
色谱分离及分离纯化介质的设计与合成；
基于扫描探针显微技术的纳微结构研究；
多肽的设计、结构与生物学功能。

1.  Di Zhang, Fangke Zhan, Ziying Wang, Li Wang, Yongjun Qiu, Tao Chen, Yibing Wang*, Liming Zhao*. Development of Biodegradable Polyamide 4/Polyvinyl Alcohol/Poly(lactic acid) Multilayer Films with Tunable Water Barrier Property and Superior Oxygen Barrier Property. ACS Appl. Polym. Mater. 2023, 5, 6, 3979–3988
2. Xuesong Yan#, Wenfeng Zhu#, Yibing Wang#, Yiran Wang, Dexuan Kong, Min Li*.“Coffee Ring” Fabrication and Its Application in Aflatoxin Detection Based on SERS. Chemosensors 2023, 11, 22.
3. Yibing Wang*, Yong Yu, Wenji Yao, Min Li*, Ping Wang, Analysis of Binding Modes of Biopanning Heptapeptides with Specific Affinity to Chitosan Wrapped MSN, BBRC, 2021, 539, 64–69.
4. Qize Xuan, Jiaxin He, Min Li, Ruoshi Chai, Chenxuan Wang*, Yibing Wang*, Ping Wang. Monomer-Targeting Affinity Peptide Inhibitors of Amyloid with No Self-Fibrillation and Low Cytotoxicity. Chemical Communications, 2020, 56, 1633–1636.
5.  Fan Shi, Lingfeng Gan, Yibing Wang*, Ping Wang. Impedimetric Biosensor Fabricated with Affinity Peptides for Sensitive Detection of Escherichia coli O157:H7. Biotechnology Letters, 2020, 45, 825–832.
6. Hao Dong, Wenxue Zhang, Yibing Wang*, Dong Liu*, Ping Wang. Biofilm polysaccharide display platform: A natural, renewable, and biocompatible material for improved lipase performance. Journal of Agricultural and Food Chemistry, 2020, 68, 1373–1381.
7.  Lingfeng Gan, Chao Chen, Peng Qin, Yibing Wang*, Ping Wang*. Silver nanoparticle-functionalized polydopamine nanotubes for highly sensitive nanocomposite electrode sensors. Journal of Electroanalytical Chemistry, 2020, 861, 113961.
8. Chao Chen, Wenji Yao, Wen Sun, Tianyuan Guo, Hangya Lv, Xiaoli Wang, Hanjie Ying, Yibing Wang*, Ping Wang*. A self-targeting and controllable drug delivery system constituting mesoporous silica nanoparticles fabricated with a multi-stimuli responsive chitosan-based thin film layer. International Journal of Biological Macromolecules, 2019, 122, 1090–1099.
9.  Wen Sun#, Yibing Wang#, Wenxue Zhang, Hanjie Ying*, Ping Wang*. Novel design of a surfactant peptide for removal of biofilms. Colloids and Surfaces B: Biointerfaces, 2018, 172, 180–186.
10. Wenfeng Zhu#, Yibing Wang#, Dan Xie, Linxiu Cheng, Ping Wang, Qingdao Zeng*, Min Li*, Yuliang Zhao. In Situ Monitoring the Aggregation Dynamics of Amyloid‑β Protein Aβ42 in Physiological Media via a Raman-Based Frequency Shift Method. ACS. Applied Bio. Materials, 2018, 1(3), 814–824.
11.  Qingyu Chen#, Liwei Zhang#, Yonghai Feng*, Fan Shi, Yibing Wang*, Ping Wang, Lei Liu*. Dual-functional peptide conjugated gold nanorods for the detection and photothermal ablation of pathogenic bacteria. Journal of Materials Chemistry B, 2018, 6, 7643–7651.
12.  Chao Chen, Wen Sun, Hangya Lv, Hui Li, Yibing Wang*, Ping Wang*. Spacer Arm-facilitated tethering of laccase on magnetic polydopamine nanoparticles for efficient biocatalytic water treatment. Chemical Engineering Journal, 2018, 350, 949–959.
13. Chao Chen, Wen Sun, Xiaoli Wang, Yibing Wang*, Ping Wang*. Rational design of curcumin loaded multifunctional mesoporous silica nanoparticles to enhance the cytotoxicity for targeted and controlled drug release. Materials Science and Engineering C-Materials for Biological Applications, 2018, 85, 88–96.
14. Chao Chen, Yong Yu, Xiaoli Wang, Ping Shi, Yibing Wang*, Ping Wang*. Manipulation of pH-Sensitive interactions between podophyllotoxin-chitosan for enhanced controlled drug release. International Journal of Biological Macromolecules, 2017, 95, 451–461.
15. Xiaoxing Chen#,Yibing Wang#, Ping Wang*. Peptide-Induced Affinity Binding of Carbonic Anhydrase to Carbon Nanotubes. Langmuir, 2015, 31, 397–403.
16. Yibing Wang#,Yibao Li#,Yin Luo, Meng Xu, Xuemei Zhang, Yuanyuan Guo, Guanghong Wei*, Lihua Yuan*, Bing Gong, Yanlian Yang*, Chen Wang. Study on Molecular Cavity of Oligoamide Macrocycles by Using Scanning Tunneling Microscopy.ChemPhysChem, 2012, 13(16), 3598–3604.
17. Yibing Wang#,Lin Niu#,Yibao Li, Xiaobo Mao, Yanlian Yang*, Chen Wang*. Single Molecule Studies of Cyclic Peptides Using Molecular Matrix at Liquid/Solid Interface by Scanning Tunneling Microscopy. Langmuir, 2010, 26(21), 16305–16311.
18. Xiaobo Mao#,Yibing Wang#,Lei Liu, Lin Niu, Yanlian Yang*, Chen Wang*. Molecular-Level Evidence of the Surface-Induced Transformation of Peptide Structures Revealed by Scanning Tunneling Microscopy. Langmuir, 2009, 25(16), 8849–8853.

1.  壳聚糖亲和七肽及其筛选方法和应用。王宜冰，于勇，姚文基，王平。中国专利公开号：CN 106518968 B，授权日：2019-11-08
2.  大肠杆菌O157：H7亲和十二肽及其筛选方法和应用。王平，王宜冰，施凡，孙文，甘凌风，王超勇，刘晓骏。中国专利公开号：CN 106565826 A，授权日：2020-2-3
3.  一种利用生物被膜固定蛋白的方法。王宜冰，董浩，王平，张文学。中国专利公开号：CN110894497A，授权日：2022-7-22
4.  一种大肠杆菌-亲和噬菌体共生的生物被膜固定化展示方法。王宜冰，玄起泽，王平。中国专利公开号：CN112143726A，授权日：2022-9-13
5.  靶向微生物生物被膜的表面活性剂样多肽及其制备方法和应用。王平，王宜冰，孙文。中国专利公开号：CN 109867711 A
6.  淀粉样蛋白纤维与单体的亲和多肽的筛选方法及其在生物传感中的应用。王宜冰，王平，甘凌风，姚文基。中国专利申请号：201810953194.5
7.  一种Amylin亲和多肽及其应用。王宜冰，玄起泽，赫佳鑫。中国专利公开号：CN 110240632 A，授权日：2022-10-21
8.  一种偶氮还原酶及其应用。王宜冰，董浩，王平，郭钿媛，张文学。中国专利公开号：CN 110241094 A，授权日：2021-1-5
9. 一种纳米金咖啡环的制备方法及其在SERS检测中的应用。李敏，闫学松，王宜冰，王德松。中国专利公开号：CN 111299606 A，授权日：2021-8-13

1. 上海市自然科学基金面上项目，生物被膜相关淀粉样蛋白的胞外聚集机制与调控，2019/7-2022/6，20万元，结题，主持；
2. 国家自然科学基金青年基金面上项目，多肽对纳米颗粒的识别性亲和及其在组装生物功能纳米结构中的应用研究，2014/1-2016/12，25万元，结题，主持；
3. 华东理工大学基本科研业务费，抗体-亲和肽-纳米颗粒（scFv-SBP-MSN）靶向型药物载体的组装规律及其与细胞的作用机制，2015/11-2017/12，16万元，结题，主持；
4. 华东理工大学基本科研业务费，寡糖色谱分离树脂合成及相互作用研究，2024/1-2024/12，10万元，结题，主持；
5. 华东理工大学基本科研业务费，生物基聚丁内酰胺生物安全性研究，2023/1-2023/12，10万元，结题，主持；
6. 横向项目（万华化学集团），生物酶在乳化液环境中活性与稳定性测试与优化，2017/10-2018/10，10万，结题，主持；
7. 国家自然科学基金面上项目，靶向性活性大分子用于食品生物污染控制的研究，2015/1-2018/12，84万元，结题，骨干。

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