论文著作：
1. K. Shi#, J.-M. Li#, M.-Q. Wang, Y.-K. Zhang, Z.-J. Zhang, Q. Chen, F. Hollmann, J.-H. Xu, H.-L.Yu*. Computation-driven redesign of an NRPS-like carboxylic acid reductase improves activity and selectivity. Sci. Adv.2024. DOI: 10.1126/sciadv.adp6775 (构建了基于近攻击构象概率和酶底物结合能的物理模型，建立了计算驱动的羧酸还原酶高通量筛选方法).
2. J.-M. Li, K. Shi, A.-T. Li, Z.-J. Zhang*, H.-L. Yu *, J.-H. Xu. Development of a thermodynamically favorable multi-enzyme cascade reaction for efficient sustainable production of ω-amino fatty acids and α,ω-diamines.ChemSusChem, 2024, 17(6). DOI10.1002/cssc.202400204 (封面论文，构建多酶级联合成氨基脂肪酸和二元胺)
3. K. Shi, J.-M. Li, Z.-J. Zhang, Q. Chen, J.-H Xu, H.-L. Yu*. Virtual screening of carboxylic acid reductases for biocatalytic synthesis of 6-aminocaproic acid and 1,6-hexamethylenediamine.Biotechnol. Bioeng., 2023, 120: 1773-1783.(基于计算建模虚拟筛选羧酸还原酶用于生物合成己二胺)
4. Y.-Q. Wu, C.-C. Chen, Q. Chen, Q. Geng, Q.-Y. Zhang, Y.-C. Zheng, C. Zhao, Y. Zhang, J.-H. Zhou, B.-J. Wang*, J.-H. Xu *, H.-L. Yu *. Precise regulation of the substrate selectivity of Baeyer‐Villiger monooxygenase to minimize overoxidation of prazole sulfoxides. Chin. J. Catal., 2023, 51, 157-167 (揭示了影响硫醚/亚砜两种十分相似底物选择性的分子调控机制，有效解决了硫醚过氧化难控制的问题)
5. Y.-C. Zheng, F.-L. Li, Z.-M. Lin, G.-Q. Lin, R. Hong*, H.-L. Yu*, J.-H Xu* Structure-guided tuning of a hydroxynitrile lyase to accept rigid pharmaco aldehydes. ACS Catal., 2020, 10, 5757-5763. (基于结构微调设计可接受刚性药物中间体醛的羟氰裂解酶)
6. N. Xu, J. Zhu, Y.-Q. Wu, Y. Zhang, J.-Y. Xia, Q. Zhao, G.-Q. Lin, H.-L. Yu*, J.-H Xu*. Enzymatic preparation of the chiral (S)-sulfoxide drug esomeprazole at pilot scale levels.Org. Process Res. Dev., 2020, 24, 1124-1130. (首次实现了百升级规模抗胃溃疡药物艾司奥美拉唑的酶法生产)
7. Y. Zhang, Y.-Q. Wu, N. Xu, Q. Zhao, H.-L. Yu*, J.-H Xu. Engineering of cyclohexanone monooxygenase for the enantioselective synthesis of S-omeprazole, ACS Sustain. Chem. Eng.,2019, 7, 7218−7226. (采用分区重组酶聚焦进化方法创制人工拉唑硫醚单加氧酶)
8. F.-L. Li #, X.-D. Kong #, Q. Chen, Y.-C. Zheng, Q. Xu, F.-F. Chen, L.-Q. Fan, G.-Q. Lin, J.-H. Zhou*, H.-L. Yu*, J.-H. Xu*. Regioselectivity engineering of epoxide hydrolase: Near-perfect enantioconvergence through a single site mutation, ACS Catal., 2018,8, 8314–8317 (成功靶向酶的区域选择性关键位点，构建完美对映归一性的环氧水解酶).
9. R.-J. Li, J.-H. Xu*, Q. Chen, J. Zhao, A.-T. Li, H.-L. Yu*. Enhancing the catalytic performance of a CYP116B monooxygenase by transdomain combination mutagenesis, ChemCatChem, 2018, 10, 1-8 (封面文章，创新性地提出跨域重组的酶聚焦进化方法).
10. H.-L. Yu*, T. Li, F.-F. Chen, X.-J. Luo, A.-L. Li, C. Yang, G.-W. Zheng, J.-H. Xu*.Bioamination of alkane with ammonium by an artificially designed multienzyme cascade, Metab. Eng., 2018, 47, 184-189. (从头设计构建多酶级联催化烷烃胺化的全新路径)
郁惠蕾
上海市
研究领域：
精细化工,生物医药
研究方向：
1.新酶基因挖掘和理性设计方法开发
2.新型萜类羟化酶的发现和分子改造
3.系统生物催化合成重要精细化学品
所在单位：
华东理工大学
