论文著作：
1. Yan Wei#, Yu-Cong Zheng#, Hai-Ping Liu, Qiang Geng, Zheng Wang, Yu-Qing Wang, Hui-Lei Yu, Jian-He Xu, Zhi-Jun Zhang*. An engineered meso-diaminopimelate dehydrogenase enables the biocatalytic synthesis of bulky β-substituted D-amino acids. ACS Catalysis 2025, 15: 7720-7730.
2. Yan Wei#, Qiang Geng#, Hai-Ping Liu#, Yu-Qing Wang#, Guo-Feng Zhang, Xiao-Long Qian, Hui-Lei Yu, Jian-He Xu, Zhi-Jun Zhang*. Hierarchical engineering of meso-diaminopimelate dehydrogenase for efficient synthesis of bulky D-amino acids. ACS Catalysis 2024, 14: 11447-11456.
3. Ju-Mou Li, Kun Shi, Ai-Tao Li, Zhi-Jun Zhang*, Hui-Lei Yu*, Jian-He Xu. Development of a thermodynamically favorable multi-enzyme cascade reaction for efficient sustainable production of ω-amino fatty acids and α,ω-diamines. ChemSusChem 2024, 17: e202301477.
4. Xing Yu, Xin-Yi Chen, Hui-Lei Yu, Jian-He Xu, Zhi-Jun Zhang*. Regio- and stereo-selective amination of fatty acids to D-amino acids by a three-step one-pot cascade. Green Chemistry 2023, 25: 3469-3474.
5. Yi-Ke Qi, Yu-Cong Zheng, Qi Chen, Yucai He, Zhi-Jun Zhang*, Jian-He Xu*. Improving the oxygenation performance of a cyanobacterial lipoxygenase by oxygen channel engineering. ACS Sustainable Chemistry & Engineering 2021, 9: 12514-12519.
张志钧
上海市
研究领域：
精细化工,生物医药
研究方向：
1. 新型生物催化剂的挖掘设计与分子改造
采用基因数据库挖掘或从头设计策略获得功能化学品生物合成途径的元件酶，解析关键限速酶的催化机制和结构-功能关系，并开展功能导向的酶分子改造提升催化性能。
2. 功能化学品生物合成途径的设计与优化
采用逆向合成策略从头设计由廉价原料合成高附加值功能化学品的生物合成途径，构建体内/体外多酶级联催化体系或对元件酶进行组装构建多酶分子机器，并进行系统测试与优化提高合成效率。
所在单位：
华东理工大学
