生物医药

基于分子模拟和复杂网络的酶结构-功能关系研究和理性设计改造。

1. Zhu ZY, Shi M, Li CL, Gao YF, Shen XY, Ding XW, Chen FF, Xu JH, Chen Q*, Zheng GW*. An engineered imine reductase for highly dastereo- and enantioselective synthesis of β-Branched amines with contiguous stereocenters. Angew. Chem. Int. Ed., 2024, e202408686.
2. Wu Q#, Li HP#, Liu Y, Shou C, Chen Q*, Xu JH*, Li CX*, Discovery and engineering of a bacterial (+)-pulegone reductase for efficient (–)-menthol biosynthesis, ChemSusChem, 2024, e202400704
3. Gao CY, Yang GY, Ding XW, Xu JH, Cheng X*, Zheng GW*, Chen Q*, Engineering of halide methyltransferase BxHMT through dynamic cross‐correlation network. Angew. Chem. Int. Ed., 2024, 63(25): e202401235.
4. 陈琦, 张诗雨, 高春玉, 郑高伟, 许建和*. 卤代甲基转移酶的发现与应用研究进展. 华东理工大学学报（自然科学版）, 2024, 50(1): 1–3.
5. Wu Y#, Chen Q#, Chen Q#, Geng Q, Zhang Q, Zheng YC, Zhao C, Zhang Y, Zhou J, Wang B, Xu JH*, Yu HL*.  Precise regulation of the substrate selectivity of Baeyer-Villiger monooxygenase to minimize overoxidation of prazole sulfoxides. Chin. J. Catal., 2023, 51: 157–167.
6. Yang GY, Zheng GW, Zeng BB*, Xu JH*, Chen Q*. Engineering of halide methyltransferases for synthesis of SAE and its application in biosynthesis of ethyl vanillin. Mol. Catal., 2023, 550: 113533.
7. Hao YC, Zong MH, Chen Q*, Li N*. Engineering carbonyl reductase for one-pot chemobiocatalytic enantioselectivesynthesis of value-added N-containing chiralalcohol from N-acetyl-D-glucosamine. Green Chem., 2023, 25(13): 5051-5058.
8. Chen Q#, Li BB#, Zhang L#, Chen XR, Zhu XX, Chen FF, Shi M, Chen CC, Yang Y, Guo RT*, Liu  W, Xu JH, Zheng GW*. Engineered imine reductase for larotrectinib intermediate manufacture. ACS Catal., 2022, 12: 14795–14803.
9. 王慕镪，陈琦*，马薇，李春秀，欧阳鹏飞，许建和*. 机器学习方法在酶定向进化中的应用进展. 生物技术通报，2023, 39(2): 12–22.
10. Wang X, Wang Z, Zhu G, Jiang L, Zhang W, Huang Y, Cong Z, Zhao YL, Xu JH, Hsiang T, Zhang L, Chen Q*, Liu X*. Chemical control over the conversion between bicyclic and polycyclic terpenes by fungal bifunctional terpene synthases. Chem Commun (Camb)., 2022, 58(68): 9476–9479.
11. Wang DH#, Chen Q#, Yin SN#, Ding XW, Zheng YC, Zhang Z, Zhang YH, Chen FF*, Xu JH*, Zheng GW*, Asymmetric reductive amination of structurally diverse ketones with ammonia using a spectrum-extended amine dehydrogenase, ACS Catal., 2021, 11: 14274–14283.
12. Yang ZY, Hao YC, Hu SQ, Zong MH, Chen Q*, Li N*. Direct reductive amination of biobased furans to N-substituted furfurylamines by engineered reductive aminase. Adv. Synth. Catal., 2021, 363: 1033–1037.

作为项目负责人主持国家自然科学基金面上项目、国家自然科学基金青年项目、上海市自然科学基金探索项目、上海市自然科学基金面上项目、博士后基金、中央高校基本科研业务费各1项，企业横向课题2项；作为研究骨干参与国家重点研发计划项目，国家重点研发计划青年项目各1项。