论文著作：
1. Zhang YB, Xiao G, Ding HY, Zou Q, Ma JB, Gu D, Wen JC, Pei YG, Guo RX*, Wang QY*, Zhou XH*. Direct sensing of host ferric iron by an archetype histidine kinase mediates virulence of an enteric pathogen. PNAS, 2025, 122: e2507874122.
2. Li CL, Zhang BY, Zhang YX, Wang QY*, Shao S*. Bacterial anti-toxin HigA dysregulates host intestinal serotonin homeostasis in a T6SS-dependent manner. Cell Rep, 44:116212.
3. Peng Y, Wu JZ, Sun Y, Zhang YX, Wang QY, Shao S*. Contrastive-learning of Language Embedding and Biological Features for Cross Modality Encoding and Effector Prediction. Nat Commun, 2025, 16:1299.
4. Peng Y, Liu YH, Zhang YX, Shao S*, Wang QY. ArgR-dependent bacterial resistance to host lipid droplet in Edwardsiella piscicida. Commun Biol. 2025, accepted.
5. Zhou MQ, Liu YB, Zhang YX, Ma Y, Zhang YB, Choi SH, Shao S*, Wang QY. Type III secretion system effector YfiD inhibits the activation of host poly(ADP-ribose) polymerase-1 to e bacterial infection. Commun Biol. 2024, 7(1):162.
6. Liu YB, Zhou MQ, Bu YF, Qin L, Zhang YX, Shao S*, Wang QY. Lysine acetylation regulates the AT-rich DNA possession ability of H-NS. Nucleic Acids Res. 2024, 52:1645-1660.
7. Ma RQ#, Liu YB#, Gan JH#, Qiao HX, Ma JB, Zhang Y, BuYF, Shao S, Zhang YX, Wang QY*. Xenogeneic nucleoid-associated EnrR thwarts H-NS silencing of bacterial virulence with unique DNA binding. Nucleic Acids Res. 2022, 50:3777-3798.
8. Shao S, Zhang Y, Yin KY, Zhang YX, Wei LF, Wang QY*. FabR senses long chain unsaturated fatty acids to control virulence in pathogen Edwardsiella piscicida. Mol Microbiol. 2022, 117: 737-753.
9. Gu D#, Zhang Y#, Wang QY#, Zhou XH*. S-nitrosylation-mediated activation of a histidine kinase represses the type 3 secretion system and es virulence of an enteric pathogen. Nat Commun. 2020, 11: 5777.
10. Zhang J, Liu B, Gu D, Hao Y, Chen M, Ma Y, Zhou XH, Reverter D*, Zhang YX, Wang QY*. Binding site profiles and N-terminal minor groove interactions of the master quorum-sensing regulator LuxR enable flexible control of gene activation and repression. Nucleic Acids Res. 2021, 49: 3274-3293.
11. Wei LF, Qiao HX, Sit B, Yin KY, Yang GH, Ma RQ, Ma JB, Yang C, Yao J, Ma Y, Xiao JF, Liu XH, Zhang YX, Waldor MK, Wang QY*. A bacterial pathogen senses host mannose to coordinate virulence. iScience. 2019, 20: 310-323.
12. Yin KY, Guan YP, Ma RQ, Wei LF, Liu B, Liu XH, Zhou XS, Ma Y, Zhang YX, Waldor MK, Wang QY*. Critical role for a er discriminator in RpoS control of virulence in Edwardsiella piscicida. PLoS Pathogens, 2018, 14: e1007272.
13. Yang Z, Zhou XH, Ma Y, Zhou M, Waldor MK, Zhang YX, Wang QY*. Serine/threonine kinase PpkA coordinates the interplay between T6SS2 activation and quorum sensing in the marine pathogen Vibrio alginolyticus. Environ Microbiol, 2018, 20:903-919.
14. Yang GH, Billings G, Hubbard TP, Park JS, Leung KY, Liu Q, Davis BM, Zhang YX, Wang QY*, Waldor MK. Time resolved transposon insertion sequencing reveals genome-wide fitness dynamics during infection. mBio, 2017, 8: e01581-17.
15. Gu D, Guo M, Yang MJ, Zhang YX, Zhou XH*, Wang Qiyao*. A σE-mediated temperature gauge controls a switch from luxr-mediated virulence gene expression to thermal stress adaptation in Vibrio alginolyticus. PLoS Pathog, 2016, 12: e1005645.
16. Lu Li#, Qiyao Wang#, Hui Zhang and Xiaohui Zhou. A histidine sensor kinase detects beta-lactams and induces resistance to beta-lactam antibiotics. PNAS, 2016, 113:1648-53.
发明专利：
1. 刘琴, 张元兴, 杨朝, 王启要. 细菌表面展示新系统、方法及应用. ZL 101182516, 2008.05.21
2. 刘琴, 张元兴, 杨朝, 王启要. 新型细菌表面展示系统、方法及应用. ZL 101195823, 2008.06.11
3. 张元兴, 王鑫, 王启要, 刘琴. 一种迟钝爱德华氏菌野生毒株的无标记基因缺失减毒突变株及其应用, ZL 200910052707.6
4. 王启要, 张元兴, 刘欢, 刘琴. 一种溶藻弧菌减毒株的无标记基因缺失减毒突变株、相关制剂其应用, 中国发明专利. 申请号：ZL 201110266453.5
5. 王启要, 陈涛, 王鑫, 肖婧凡, 刘琴, 张元兴. 迟钝爱德华氏菌野生毒株的无标记基因缺失减毒株、相关制剂及其应用, 中国发明专利. ZL 201010541646.2
6. 刘琴，张元兴，周凌云，王启要. 一种多效价活疫苗、其制备方法及应用. 中国发明专利. ZL200910054113.9
7. 张元兴, 王启要, 刘琴, 吴海珍, 肖婧凡. 迟钝爱德华氏菌天然弱毒株及其应用. 中国发明专利. ZL201210240313.5
8. 王启要, 刘琴, 张元兴, 王亚敏, 吴海珍, 肖婧凡. 迟钝爱德华氏菌突变株及其应用, PCT国际专利: PCT/CN2012/076961
9. 王启要, 王亚敏, 刘琴, 吴海珍, 肖婧凡, 张元兴. 鱼用多效价活疫苗及其应用, 中国发明专利. ZL201210492313.4
10. 王启要，马瑞青，张元兴，刘琴. 新型爱德华氏菌减毒靶点及其应用. 中国发明专利. ZL201910079586.8
10. 刘琴, 张元兴, 郑雁, 王启要. 一种抗鳗弧菌和迟钝爱德华氏菌的多效价活疫苗、相关表达载体及应用. 中国发明专利. ZL201010600524.6
11. 肖婧凡, 张元兴, 刘和松, 王启要, 刘琴. 迟钝爱德华氏菌快速检测试纸条及快速检测方法与应用. 中国发明专利. ZL201010568826.X
12. 吴海珍, 张萌, 李小勇, 沈斌兵, 王启要, 张元兴. 迟钝爱德华氏菌免疫保护性抗原、相关表达载体、疫苗和应用. 中国发明专利. 专利号：ZL201110095826.7
王启要
上海市
研究领域：
生物医药
研究方向：
1、病原病害快速诊断、病原宿主互作致病机制和疫苗工程(疫苗生物工程)
2、生物活性物质高通量筛选、功能鉴定、生物合成和产品开发(海洋生物工程)
所在单位：
华东理工大学
