生物医药

天然活性物质的研究与应用
1. 天然产物的生物活性及作用机理研究：探究了多种天然产物对肥胖、糖尿病、免疫和炎性肠病等疾病的作用效果，及其对肠道微生物和体内代谢通路的作用机制；
2. 天然多糖的提取纯化及构效分析：对天然多糖的提取纯化、活性机制、构效关系分析以及高附加值产品开发进行全过程的探究；
3. 功能性食品的应用开发：“面向人民生命健康”开发多种形式功能性产品，充分发挥天然活性物质和食品营养价值。

Xu, N., Zhou, Y., Lu, X., & Chang, Y.*. (2021). Auricularia auricula-judae (Bull.) polysaccharides improve type 2 diabetes in HFD/STZ-induced mice by regulating the AKT/AMPK signaling pathways and the gut microbiota. J Food Sci. 86: 5479– 5494.
Zhou, Y., Xu, N., Zhang, X., Zhu, Y., Liu, S., Chang, Y.*. (2021), Chrysin Improves Glucose and Lipid Metabolism Disorders by Regulating the AMPK/PI3K/AKT Signaling Pathway in Insulin-Resistant HepG2 Cells and HFD/STZ-Induced C57BL/6J Mice. J Agric Food Chem. 69(20):5618-5627.
缪书婷,钱家祯,卢千山, 常雅宁*，徐涛，郭歆雨. 二十八烷醇微乳液的毒理学评价[J]. 食品科技,2021,46(3):220-224.
Zhang, X., Lu, X., Zhou, Y., Guo, X. and Chang, Y*. (2021), Major royal jelly proteins prevents NAFLD by improving mitochondrial function and lipid accumulation through activating the AMPK / SIRT3 pathway in vitro. J Food Sci, 86: 1105-1113.
屈咪,朱雨燕,周英骏, 郭歆雨，庄伟，常雅宁*. 黑木耳多糖的消化产物对免疫功能的影响[J]. 食品科技,2021,46(4):149-154.
Zhao, D., Dai, W., Tao, H., Zhuang, W., Qu, M. and Chang, Y. * (2020), Polysaccharide isolated from Auricularia auricular-judae (Bull.) prevents dextran sulfate sodium-induced colitis in mice through modulating the composition of the gut microbiota. J Food Sci, 85: 2943-2951.
庄伟, 屈咪, 赵迪, 常雅宁*. 黑木耳多糖的结构组成及其免疫活性研究[J]. 食品科技, 2020, 45(02):205-210.
Zhou, Y., Chang, Y.*, You, J., Li, S., Zhuang, W. and Cao, C.. (2019), Cold‐pressed Canola Oil Reduces Hepatic Steatosis by Modulating Oxidative Stress and Lipid Metabolism in KM Mice Compared with Refined Bleached Deodorized Canola Oil. J Food Sci, 84: 1900-1908. doi:10.1111/1750-3841.14504
You, J., Chang, Y.*, Zhao, D., Zhuang, J. and Zhuang, W. (2019), A Mixture of Functional Complex Extracts from Lycium barbarum and Grape Seed Enhances Immunity Synergistically In Vitro and In Vivo. J Food Sci, 84: 1577-1585.
黎穗子, 胥孙婕, 曹承嘉, 常雅宁*. 青稞苗二十六烷醇的提取优化及其预防HepG2细胞脂质过氧化研究[J]. 食品科技, 2019, 44(01):268-273.
常雅宁*, 彭钰珂, 魏东芝, 胡晓鸣. 虚拟仿真技术在酶工程实验教学上的应用[J]. 实验室研究与探索, 2019, 38(02):237-239+244.
孔沛筠, 常雅宁*, 聂嘉睿, 庄伟, 屈咪, 秦佳文. 木耳多糖提取工艺优化及其体外抗氧化活性研究[J]. 食品与药品, 2018,20(03):187-193.
孔沛筠, 常雅宁*, 屈咪, 庄伟. 灭菌方式对木耳感官品质的影响[J]. 食品工业, 2018, 39(12):80-83.
Nie, J., Chang, Y. *, Li, Y., Zhou, Y., Qin, J., Sun, Z., Li, H.. (2017), Caffeic Acid Phenethyl Ester (Propolis Extract) Ameliorates Insulin Resistance by Inhibiting JNK and NF-κB Inflammatory Pathways in Diabetic Mice and HepG2 Cell Models. J Agric Food Chem. 65(41):9041-9053.
Chang, Y., Peng, Y., Li, P., Zhuang, Y.. Practices and exploration on competition of molecular biological detection technology among students in food quality and safety major[J]. biochemistry & molecular biology education a bimonthly publication of the international union of biochemistry & molecular biology, 2017, 45(4):343.
Chang, Y.*, Lv, Y.. (2017), Structure, functionality, and digestibility of acetylated hulless barley starch[J]. International Journal of Food Properties. 20(5-8):1818-1828.
马征, 常雅宁*. 微波消解-ICP-OES法同时测定婴幼儿奶粉中的14种无机元素[J]. 中国乳品工业, 2017,45(01):43-46+60.

1. 血红蛋白肉红色素制备方法，申请号：200610148003.5
2. 天然淀粉粘胶剂及其制备方法和在杂粮工程米中的应用，申请号2104103263973
3. 一种低血糖生成指数营养粉，申请号2015107694446
4. 一种低血糖生成指数蜂蜜及其制备方法，申请号201510050069
5. 一种枸杞多糖软糖及其制备方法，申请号201810421671.3

1. 椴树蜜辅助降血糖功能产品开发（上海市农委科技兴农重点项目，在研）
2. 蜂王浆功能因子研究及蜂王浆新产品研发（上海市农委科技兴农重点项目，已结题）
3. 蜂产品的开发（上海市科委联盟计划，已结题）
4. 蜂胶功能因子及蜂胶新产品研制开发（上海市农委科技兴农重点项目，已结题）
5. 血红色素的特性研究（上海市科委重大应用专项，已结题）
6. 血红色素制备工艺研究（上海市科委重大应用专项，已结题）

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