论文著作：
1. Structural Insight into Enantioselective Inversion of an Alcohol Dehydrogenase Reveals a “Polar Gate” in Stereorecognition of Diaryl Ketones. Journal of the American Chemical Society (2018) 140: 12645-12654
2. Structure-guided engineering of D-carbamoylase reveals a key loop at substrate entrance tunnel. ACS Catalysis (2020) 10, 12393-12402
3. Stereochemistry in asymmetric reduction of bulky-bulky ketones by alcohol dehydrogenases. ACS Catalysis (2020) 10, 10954-10966
4. Hydroclassified Combinatorial Saturation Mutagenesis: Reshaping Substrate Binding Pockets of KpADH for Enantioselective Reduction of Bulky-bulky Ketones. ACS Catalysis (2018) 8: 8336–8345
5. Kinetic Resolution of Nearly Symmetric 3-Cyclohexene-1-carboxylate Esters Using a Bacterial Carboxylesterase Identified by Genome Mining. Organic Letters (2021) DOI: 10.1021/acs.orglett.1c00714
6. Engineering an Alcohol Dehydrogenase for Balancing Kinetics in NADPH Regeneration with 1,4-Butanediol as a Cosubstrate. ACS Sustainable Chemistry & Engineering (2019) 7: 15706−15714
7. Engineering an Alcohol Dehydrogenase from Kluyveromyces polyspora for Efficient Synthesis of Ibrutinib Intermediate. Advanced Synthesis & Catalysis (2020) DOI: 10.1002/adsc.202001313
8. Hyperconjugation promoted by hydrogen bonding between His98/His241 and a carboxyl group contributes to tyrosine decarboxylase catalysis. Catalysis Science & Technology (2019) 9: 6222-6226
9. Engineering of Cyclodextrin Glycosyltransferase Reveals pH-Regulated Mechanism of Enhanced Long-Chain Glycosylated Sophoricoside Specificity. Applied and Environmental Microbiology (2020) 86: e00004-20
10. Novel dihydrogen-bonding deep eutectic solvents: pretreatment of rice straw for butanol fermentation featuring enzyme recycling and high solvent yield. Chemical Engineering Journal (2018) 333:712-720
发明专利：
1. US10,822,593B2/PCT/CN2018/094505 Alcohol Dehydrogenase Mutant and Application thereof in Synthesis of Diaryl Chiral Alcohols
2. US10,865,390B2/PCT/CN2018/094506 Alcohol Dehydrogenase Mutant and Application thereof in Synthesis of Diaryl Chiral Alcohols
3. US11078465B2/PCT/CN2018/094507 Alcohol Dehydrogenase Mutant and Application thereof in Synthesis of Diaryl Chiral Alcohols
4. US11162124B2/PCT/CN2018/118368 Alcohol Dehydrogenase Mutant and its Application to Coenzyme Regeneration
5. US2021/0108182A1/PCT/CN2020/091254 Method for Producing Long-chain Glycosylated Genistein
6. 一种醇脱氢酶突变体及其应用 ZL2019111752550
7. 一种ω-转氨酶突变体及其在生产手性芳香胺中的应用 ZL2019111841126
8. 一种杂环类药物中间体的高效制备方法 ZL201911120248
9. 一株不动杆菌及其在生产手性3-环己烯-1-甲酸中的应用 ZL201910380623.9
10. 还原胺化酶、编码基因、重组载体、重组细胞及其应用 ZL201911064851.1
科研项目：
1. 国家重点研发计划合成生物学专项(2021YFC2102700) 项目负责人 （2021.12-2024.11）
2. 国家重点研发计划合成生物学专项（2018YFA0901701）子课题负责人（2019.7-2024.6）
3. 2020年国家自然科学基金面上项目（22077054）
4. 2017年国家自然科学基金面上项目（21776112）
5. 2015年江苏省杰出青年基金（BK20150003）
6. 2013年国家自然科学基金面上项目（21276112）
7. 2015年江苏省产学研合作项目（BY2015019-19）
8. 973项目子课题：不对称基元生化反应的热/动力学（2011CB710803）
倪晔
江苏省
研究领域：
精细化工,生物医药
研究方向：
手性生物催化和酶工程
所在单位：
江南大学
