论文著作：
1、Lunjie Wu, Jianhong An, Xiaoran Jing, Chun-Chi Chen, Longhai Dai, Yan Xu, Weidong Liu,* Rey-Ting Guo,* and Yao Nie*. Molecular insights into the regioselectivity of the Fe(II)/2-ketoglutarate-dependent dioxygenase-catalyzed C−H hydroxylation of amino acids. ACS Catalysis, 2022, 12: 11586-11596.
2、Lunjie Wu, Lei Qin, Yao Nie, Yan Xu, Yi-Lei Zhao. Computer-aided understanding and engineering of enzymatic selectivity. Biotechnology Advances, 2022, 54: 107793
3、Jie Gu, Byu Ri Sim, Jiarui Li, Yangqing Yu, Lei Qin, Lunjie Wu, Yu Shen, Yao Nie, Yi-Lei Zhao, Yan Xu. Evolutionary coupling-inspired engineering of alcohol dehydrogenase reveals the influence of distant sites on its catalytic efficiency for stereospecific synthesis of chiral alcohols. Computational and Structural Biotechnology Journal, 2021, 19: 5864-5873.
4、Jiahua Bi, Xiaoran Jing, Lunjie Wu, Xia Zhou, Jie Gu, Yao Nie, Yan Xu. Computational design of noncanonical amino acid-based thioether staples at N/C-terminal domains of multi-modular pullulanase for thermostabilization in enzyme catalysis. Computational and Structural Biotechnology Journal, 2021, 19: 577-585.
5、Lei Qin, Lunjie Wu, Yao Nie, Yan Xu. Biosynthesis of chiral cyclic and heterocyclic alcohols via C=O/C-H/C-O asymmetric reactions. Catalysis Science & Technology, 2021, 11:2637-2651. (封面文章)
6、Dan-Ping Zhang, Xiao-Ran Jing, Lun-Jie Wu, An-Wen Fan, Yao Nie, Yan Xu. Highly selective synthesis of d-amino acids via stereoinversion of corresponding counterpart by an in vivo cascade cell factory. Microbial Cell Factories, 2021, 20: 11.
7、Jiahua Bi, Shuhui Chen, Xianghan Zhao, Yao Nie, Yan Xu. Computation-aided engineering of starch-debranching pullulanase from Bacillus thermoleovorans for enhanced thermostability. Applied Microbiology and Biotechnology, 2020, 104: 7551-7562.
8、Han Zu, Jie Gu, Hui Zhang, Anwen Fan, Yao Nie, Yan Xu. Highly enantioselective synthesis of (R)-1,3-butanediol via deracemization of the corresponding racemate by a whole-cell stereoinverting cascade system. Microbial Cell Factories, 2020, 19: 125.
9、Xinye Wang, Xiaoran Jing, Yi Deng, Yao Nie*, Fei Xu, Yan Xu, Yi-Lei Zhao, John F. Hunt, Gaetano T. Montelione, Thomas Szyperski. Evolutionary coupling saturation mutagenesis: Coevolution-guided identification of distant sites influencing Bacillus naganoensis pullulanase activity. FEBS Letters, 2020, 594: 799-812. (封面文章)
10、Jianhong An, Yao Nie*, Yan Xu. Structural insights into alcohol dehydrogenases catalyzing asymmetric reductions. Critical Reviews in Biotechnology, 2019, 39: 366-379.
11、Xinye Wang, Yao Nie*, Yan Xu. Industrially produced pullulanases with thermostability: Discovery, T engineering, and heterologous expression. Bioresource Technology, 2019, 278: 360-371.
12、Beibei Liu, Ge Qu, Jun-Kuan Li, Wenchao Fan, Jun-An Ma, Yan Xu, Yao Nie*, Zhoutong Sun*. Conformational dynamics-guided loop engineering of an alcohol dehydrogenase: capture, turnover and enantioselective transformation of difficult-to-reduce ketones. Advanced Synthesis & Catalysis, 2019, 361: 3182-3190.
13、Yao Nie, Shanshan Wang, Yan Xu, Shengan Luo, Yi-Lei Zhao, Rong Xiao, Gaetano Montelione, John F Hunt, Thomas Szyperski. Enzyme engineering based on X-ray structures and kinetic profiling of substrate libraries: alcohol dehydrogenases for stereospecific synthesis of a broad range of chiral alcohols, ACS Catalysis, 2018, 8: 5145-5152. (封面文章)
14、Xinye Wang, Yao Nie*, Yan Xu. Improvement of the activity and stability of starch-debranching pullulanase from Bacillus naganoensis via tailoring of the active sites lining the catalytic pocket. Journal of Agricultural and Food Chemistry, 2018, 66: 13236-13242.
15、Shanshan Wang, Yao Nie*, Yan Xu, Rongzhen Zhang, Tzu-Ping Ko, Chun-Hsiang Huang, Hsiu-Chien Chan, Rey-Ting Guo, Rong Xiao. Unconserved substrate-binding sites direct the stereoselectivity of medium-chain alcohol dehydrogenase. Chemical Communications, 2014, 50(58): 7770-7772. (封面文章)
聂尧
江苏省
研究领域：
精细化工,生物医药
研究方向：
微生物分子酶学与催化工程的理论及应用等
所在单位：
江南大学
