生物医药

发酵工程，发酵过程优化与控制

1、Hu WB#, Feng SS*#, Tong YJ, Zhang HL, Yang HL*. Adaptive defensive mechanism of bioleaching microorganisms under extremely environmental acid stress: Advances and perspectives. Biotechnology Advances, 2020, 42:107580.
2、 Feng SS#, Gong LQ#, Zhang YK, Tong YJ, Zhang HL, Zhu DQ, Huang X, Yang HL*. Bioaugmentation potential evaluation of a bacterial consortium composed of isolated Pseudomonas and Rhodococcus for degrading benzene, toluene and styrene in sludge and sewage. Bioresource Technology, 2021, 320:124329.
3、Feng SS, Jiang ZM, Chen YQ, Gong LQ, Tong YJ, Zhang HL, Huang X, Yang HL*. Simultaneous denitrification and desulfurization-S0 recovery of wastewater in trickling filters by bioaugmentation intervention based on avoiding collapse critical points. Journal of Environmental Management, 2021, 292:112834.
4、Feng SS, Yin YJ, Yin ZW, Zhang HL, Zhu DQ*, Tong YJ, Yang HL*. Simultaneously enhance iron/sulfur metabolism in column bioleaching of chalcocite by pyrite and sulfur oxidizers based on joint utilization of waste resource. Environmental Research, 2021, 194:110702.
5、Yin ZW#, Feng SS*#, Tong YJ, Yang HL*. Adaptive mechanism of Acidithiobacillus thiooxidans under stress during bioleaching of low-grade chalcopyrite based on physiological and comparative transcriptomic analysis. Journal of Industrial Microbiology & Biotechnology, 2019, 46:1643–1656.
6、Huang ZZ#, Feng SS#*, Tong YJ, Yang HL*. Enhanced “contact mechanism” for interaction of extracellular polymeric substances with low-grade copper-bearing sulfide ore in bioleaching by moderately thermophilic Acidithiobacillus caldus. Journal of Environmental Management, 2019, 242, 11-21.
7、Zhao B, Li YF, Li CL, Yang HL*, Wang W. Enhancement of Schizochytrium DHA synthesis by plasma mutagenesis aided with malonic acid and zeocin screening. Applied Microbiology and Biotechnology, 2018, 102:2351-2361.
8、Yang HL, Wang YT, Zhang L, Shen W. Heterologous expression and enzymatic characterization of fructosyltransferase from Aspergillus niger in Pichia pastoris. New Biotechnology, 2016, 33, 164-70.
9、Feng SS, Yang HL*, Wang W*. System‑level understanding of the potential acid‑tolerance components of Acidithiobacillus thiooxidans ZJJN‑3 under extreme acid stress. Extremophiles, 2015, 19:1029-1039.
10、Yang HL, Feng SS, Xin Y, Wang W*. Community dynamics of attached and free cells and the effects of attached cells on chalcopyrite bioleaching by Acidithiobacillus sp. Bioresource Technology, 2014, 154:185-191.

1、发酵过程控制与优化专家系统，计算机软件著作权，2011SR001016
2、一种对清香型原酒品质分级的方法，国家发明专利，ZL202110460358.2
3、一种提高肌酸酶热稳定性的方法，国家发明专利，ZL 201610865045.4
4、一种利用微藻处理污水并生产生物油脂的系统及方法，国家发明专利，ZL 201110008373.X
5、一株嗜酸硫杆菌及其在黄铜矿浸出中的应用，国家发明专利，ZL 201310023949.9
6、一种底物特异性提高的胆固醇氧化酶突变体及其应用，国家发明专利，ZL 201510788289.2
7、一种自养产油微藻的高密度培养工艺，国家发明专利，ZL 201010509643.0
8、一株那不勒斯硫杆菌及其在生物脱硫中的应用，国家发明专利，ZL201410179292.X

1、细胞源（酵母）营养健康食品数字化车间（F-Y-Bioprocessor-2018-001-AQ），工信部，“中国制造2025”，2015-2020；
2、嗜酸氧化硫硫杆菌硫氧化调控机制，国家自然科学基金面上项目（21776113），2019-2022；
3、发酵食品（酱油）数字化（F-Y-Bioprocessor-2017-001-JJ），工信部，2015-2019；
4、DHA高强度发酵生产技术研究（2012AA021302），科技部863，主持，2013-2016；
5、固体发酵工艺系统优化（2012AA021302），科技部863，主持，2012-2014。

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