生物医药

酿造相关生物转化和微生物进化

1. Nan Zheng, Yongchao Cai, Zehua Zhang, Huimin Zhou, YuDeng, Shuang Du, MaiTu, WeiFang, Xiaole Xia*. Tailoring industrial enzymes for thermostability and activity evolution by the machine learning-based iCASE strategy. Nature Communications, 2025, 16(640): 2-13. DOI: 10.1038/s41467-025-55944-5（JCR 一区，IF 14.7）
2. Qingtong Zhou*, Zheng Zhang, Ling Gao, Guanyi Li, Yue Zhang, Weili Yang, Yaxue Zhao, Dehua Yang, Ming-Wei Wang*, Zhaofeng Luo*, Xiaole Xia*. Computation-Enabled Structure-Based Discovery of Potent Binders for Small-Molecule Aptamers. Journal of Chemical Theory and Computation, 2025, 324, 169129. DOI: 10.1016/j.jmb.2025.169129.（JCR 一区，IF 5.70）
3. Nan Zheng#, Mengfei Long#, Zehua Zhang, Tolbert Osire, Qijia Zan, Huimin Zhou, Shuang Du, Xiaole Xia*. Functional, structural properties and interaction mechanism of soy protein isolate nanoparticles modified by high-performance protein-glutaminase. Food Hydrocolloids, 2023, 139, 108594. DOI: 10.1016/j.foodhyd.2023.108594. （JCR 一区，IF 11.0）
4. Hui Liao, Yi Luo, Xinlei Huang, Xiaole Xia*. Dynamics of quality attributes, flavor compounds, and microbial communities during multi-driven-levels chili fermentation: interactions between the metabolome and microbiome. Food Chemistry, 2023, 405: 134936. DOI: 10.1016/j.foodchem.2022.134936. （JCR 一区，IF 8.50）
5. Nan Zheng#, Mengfei Long#, Zehua Zhang, Qijia Zan, Tolbert Osire, Huimin Zhou, Xiaole Xia*. Protein-glutaminase engineering based on isothermal compressibility perturbation for enhanced modification of soy protein isolate. Journal of Agricultural and Food Chemistry, 2022, 70(43):13969–13978. DOI: 10.1021/acs.jafc.2c06063. Cover Story（JCR 一区，IF 5.70）
6. Hao Wang, Bianbian Zhao, Yufei Ye, Xiaoyu Qi, Yuting Zhang, Xiaole Xia*, Xiaoli Wang*, Nandi Zhou. A fluorescence and surface-enhanced Raman scattering dual-mode aptasensor for rapid andsensitive detection of ochratoxin A, Biosensors and Bioelectronics, 2022, 207, 114164. DOI: 10.1016/j.bios.2022.114164（JCR 一区，IF 10.7）
7. Yingyu Wang, Chenhao Zhang, Fengsong Liu, Zhengyu Jin*, Xiaole Xia*. Ecological succession and functional characteristics of lactic acid bacteria in traditional fermented foods[J]. Critical Reviews in Food Science and Nutrition, 2022, DOI: 10.1080/10408398.2021.2025035. （JCR 一区，IF 7.3）
8. Ling Gao, Xiaodan Wu, Xiaole Xia*, Zhengyu Jin*. Fine-tuning ethanol oxidation pathway enzymes and cofactor PQQ coordinates the conflict between fitness and acetic acid production by acetobacter pasteurianus. Microbial Biotechnology, 2020, 1–13. DOI: 10.1111/1751-7915.13703. （JCR 一区，IF 4.8）
9. Yi Luo, Linghua Kong, Ruiqi Xue, Liangjie Duan, Xiaole Xia*. Bitterness in alcoholic beverages: The profiles of perception, constituents, and contributors. Trends in Food Science & Technology, 2020, 96, 222-232. DOI: 10.1016/j.tifs.2019.12.026. （JCR 一区，IF 15.10）

1. 夏小乐，高玲，一种合成Surfactin的重组枯草芽孢杆菌及其应用，2024，CN118516292A.（已转化）
2. 夏小乐，张斌，张清文，夏梅芳，金鑫华，王武，一种低产生物胺的黄酒生产工艺，2017，CN104694332B.（已转让）
3. 夏小乐，昝其佳，高玲，郑楠，一种降解尿素和氨基甲酸乙酯的双功能脲酶突变体及其应用，2024，CN116855482B.
4. 夏小乐，郑楠，龙梦飞，高玲，王颖妤，基于等温压缩系数扰动对酶进行再设计的方法、应用及通过此方法筛选出的突变体，2023，CN114220492B.
5. 夏小乐，许睿显，段亮杰，李冉，一种红曲发酵黄酒加工副产物生产γ-氨基丁酸的方法，2021，CN110205345B.
6. 纪圩，夏小乐，姚永奇，吴梦尧，高玲，罗云川，王雨芊，邓冲，罗意，一种可移动式智能式旋转曲架，2024，CN221797430U. （已转化）

1. 功能性维生素绿色生物制造关键技术研究（国家重点研发计划-2023YFF1103700），主持，2023-2027.
2. 基于合成微生物生态系统进化分析的黄酒中生物胺代谢分子机制研究（国家自然科学基金-31972064），主持，2020-2023.
3. 高性能生物纺织酶基因的挖掘与改造（国家重点研发计划-2021YFC2104001），主持，2021-2025.
4. 发酵食品产业的技术现状、发展趋势及面临的问题（中国工程院咨询研究项目-2019-XY-29-01），主持，2019-2020.
5. 特征黄酒内源性危害物动态调控应用示范研究（国家重点研发计划-2018YFC1604106），主持，2018-2021.

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