生物医药

发酵工程、酶工程、生物化工

1、Li, Jialin; Mu, Xiaoqing* ; Wu, Tao ; Xu, Yan (Xu, Yan),High coenzyme affinity chimeric amine dehydrogenase based on domain engineering, BIORESOURCES AND BIOPROCESSING, 2022,9(1).
2、Zhou, Feng ; Xu, Yan ; Nie, Yao ; Mu, Xiaoqing* , Substrate-Specific Engineering of Amino Acid Dehydrogenase Superfamily for Synthesis of a Variety of Chiral Amines and Amino Acids, Catalysts, 2022,12(4).
3、Zhou, Feng ; Xu, Yan; Mu, Xiaoqing* ; Nie, Yao,A Sustainable Approach for Synthesizing (R)-4-Aminopentanoic Acid From Levulinic Acid Catalyzed by Structure-Guided Tailored Glutamate Dehydrogenase, FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022,9.
4、Yang, Linyan; Mu, Xiaoqing* ; Nie, Yao; Xu, Yan,Improving the production of NAD(+) via multi-strategy metabolic engineering in Escherichia coli, METABOLIC ENGINEERING, 2021,64,122-133.
5、Mu, Xiaoqing* ; Wu, Tao; Mao, Yong; Zhao, Yilei; Xu, Yan; Nie, Yao,Iterative Alanine Scanning Mutagenesis Confers Aromatic Ketone Specificity and Activity of L-Amine Dehydrogenases, CHEMCATCHEM,2021,13(24) 5243-5253.
6、Wu, Tao; Mu, Xiaoqing* ; Xue, Yuyan; Xu, Yan; Nie, Yao, Structure-guided steric hindrance engineering of Bacillus badius phenylalanine dehydrogenase for efficient l-homophenylalanine synthesis, BIOTECHNOLOGY FOR BIOFUELS,2022,14(1).
7、Zhou, Feng; Mu, Xiaoqing* ; Nie, Yao; Xu, Yan,Enhanced catalytic efficiency and coenzyme affinity of leucine dehydrogenase by comprehensive screening strategy for L-tert-leucine synthesis, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2021,105(9)3625-3634.
8、Mu, Xiaoqing* ; Feng, Xian; Wu, Tao; Zhou, Feng; Nie, Yao; Xu, Yan,Transamination-Like Reaction Catalyzed by Leucine Dehydrogenase for Efficient Co-Synthesis of alpha-Amino Acids and alpha-Keto Acids, MOLECULES, 2021,26(23).
9、Luo Lei; Mu, Xiaoqing* ; Wu Tao; Nie Yao; Xu Yan, Synthesis of Norephedrine in One Pot, CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2021,42(8)2458-2464.
10、穆晓清* ,杨琳琰,徐岩, 关键酶基因转录水平对大肠杆菌合成NAD+的影响, 微生物学报,2021,61(12).

1、一种提高胞内氧化型辅酶I含量的方法，ZL201611175056.6
2、一种利用亮氨酸脱氢酶偶练葡萄糖脱氢酶制备L-叔亮氨酸的方法，ZL201610066706.7
3、一种利用亚胺还原酶生产麻黄碱的方法，ZL201910942604.0
4、亮氨酸脱氢酶突变体及其在芳香族手性胺合成中的应用，ZL201910986879.4

1、“863”子课题 “高效合成非天然α-氨基酸生物催化剂分子修饰和改造技术”(2015AA021004)
2、“国家自然科学基金重点项目” 子课题 “多酶生物分子机器的可控组装与制备药物的生物化工基础” (21336009)
3、“国家重点研发计划”子课题“关键酶的理性设计与优化”（2021YFC2100104-03）
4、“863”子课题“手性醇的生物不对称合成技术” （2011AA02A209）
5、“国家自然科学基金委面上项目” “ 基于定量结构与活性分析非水相生物催化不对称还原反应环境毒性与生物稳定性的研究” （21176103）

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