论文著作：
1、 Ruizhi Han, Ke Gao, Yulin Jiang, Jieyu Zhou, Guochao Xu, Jinjun Dong, Ulrich Schwaneberg, Yu Ji, Ye Ni. (2023) Self-Sufficient In Vitro Multi-Enzyme Cascade for Efficient Synthesis of Danshensu from l-DOPA, ACS Synthetic Biology (封面文章), , 12(1): 277-286
2、 Ruizhi Han, Honghui Fang, Zhaoyue Fan, et al. (2023) Coupled reaction of glycosyltransferase and sucrose synthase for high-yielding and cost-effective synthesis of rosin. Molecular Catalysis, 540: 113035
3、 Han, R., Chai, B., Jiang, Y., Ni, J., & Ni, Y. (2022). Engineering of cyclodextrin glycosyltransferase from Paenibacillus macerans for enhanced product specificity of long-chain glycosylated sophoricosides. Molecular Catalysis, 519, 112147.
4、 Han, R., Cao, X., Fang, H., Zhou, J., & Ni, Y. (2021). Structure-based engineering of ω-transaminase for enhanced catalytic efficiency toward (R)-(+)-1-(1-naphthyl) ethylamine synthesis. Molecular Catalysis, 502, 111368.
5、 Rui-Zhi Han, Jie Ni, Jieyu Zhou, et al. (2020) Engineering of cyclodextrin glycosyltransferase reveals pH-regulatory mechanism of enhanced long chain glycosylated sophoricoside specificity. Applied and Environmental Microbiology, 86(7), e00004-20
6、 Dong Yao, Jia Fan, Ruizhi Han*, et al. (2020) Enhancing soluble expression of sucrose phosphorylase in Escherichia coli by molecular chaperones. Protein Expression and Purification, 169, 105571
7、 Ruizhi Han, Binbin Ge, Ming Yang, et al. (2017) High production of genistein diglucoside derivative using cyclodextrin glycosyltransferase from Paenibacillus macerans. Journal of Industrial Microbiology & Biotechnology, 44, 1343-1354
8、 Rui-Zhi Han, Guo-Chao Xu, Jin-Jun Dong, Ye Ni*. Arginine deiminase: recent advances in discovery, crystal structure and protein engineering for improved properties as an anti-tumor drug. Applied Microbiology & Biotechnology (2016) 100: 4747-4760
9、 Han, R.Z., Li, J.H., Shin, H.D. et al. (2014) Recent advances in discovery, heterologous expression, and molecular engineering of cyclodextrin glycosyltransferase for versatile applications. Biotechnology Advances, 32, 415-428.
10、 Han, R.Z., Li, J.H., Shin, H.D. et al. (2014) Fusion of self-assembling amphipathic oligopeptides with cyclodextrin glycosyltransferase improves 2-O-D-glucopyranosyl-l-ascorbic acid synthesis with soluble starch as the glycosyl donor. Applied and Environmental Microbiology, 80, 4717-4724.
11、 Han, R.Z., Liu, L., Shin, H.D. et al. (2013) Iterative saturation mutagenesis of -6 subsite residues in cyclodextrin glycosyltransferase from Paenibacillus macerans to improve maltodextrin specificity for 2-Od-glucopyranosyl-l-ascorbic acid synthesis. Applied and Environmental Microbiology, 79, 7562-7568.
12、 Han, R.Z., Li, J.H., Shin, H.D. et al. (2013) Carbohydrate-binding module-cyclodextrin glycosyltransferase fusion enables efficient synthesis of 2-O-d-glucopyranosyl-l-ascorbic acid with soluble starch as the glycosyl donor. Applied and Environmental Microbiology, 79, 3234-3240.
13、 Han, R.Z., Liu, L., Shin, H.D. et al. (2013) Systems engineering of tyrosine 195, tyrosine 260, and glutamine 265 in cyclodextrin glycosyltransferase from Paenibacillus macerans to enhance maltodextrin specificity for 2-O-(D)-glucopyranosyl-(L)-ascorbic acid synthesis. Applied and Environmental Microbiology, 79, 672-677.
14、 Han, R.Z., Liu, L., Shin, H.D. et al. (2013) Site-saturation engineering of lysine 47 in cyclodextrin glycosyltransferase from Paenibacillus macerans to enhance substrate specificity towards maltodextrin for enzymatic synthesis of 2-O-D-glucopyranosyl-L-ascorbic acid (AA-2G). Applied Microbiology and Biotechnology, 97, 5851-5860.
15、 Han, R.Z., Liu, L., Li, J.H. et al. (2012) Functions, applications and production of 2-O-Dglucopyranosyl-L-ascorbic acid. Applied Microbiology and Biotechnology, 95, 313-320.
韩瑞枝
江苏省
研究领域：
生物医药
研究方向：
蛋白质工程，酶工程
所在单位：
江南大学
