生物医药

化学糖生物学、生物传感器和生物成像技术等方法学开发与应用

@ University of California San Diego
1. Lin, W., Chen, Y. and Zhang, J. Versatile Red-shifted Biosensors for in vivo Activity Imaging. (Manuscript in preparation)
2. Zhang, JF. #, Lin, W. #, Huang, L. Y., Kim, S. H., He, X. C., Frei, M. S., Zhong, H., Mehta, S. and Zhang, J. New Generation of FRET-based PKA biosensors with High Sensitivity and Selectivity. (Manuscript in preparation) (#Co-first authors)
3. Ni, G. S., Su, H., Zhu, Y., Dhiman, A., Zhou, H-X.*, Lin, W.*, and Hao, N.* Biophys. J. (Under revision) (*Co-corresponding authors) [bioRxiv (2024) doi: 10.1101/2024.11.06.622393]
4. Lin, W.*, Phatarphekar, A., Zhong, Y., Liu, L., Kwon, H-B., Gerwick, W. H., Wang, Y., Mehta S. and Zhang, J.* Light-gated Integrator for Highlighting Kinase Activity in Living Cells. Nat. Commun. 15, 7804 (2024). (*Co-corresponding authors)
5. Su, Q., Zhang, J. #, Lin, W. #, Zhang, JF., Newton, A. C., Mehta, S., Yang, J. and Zhang, J. Sensitive Fluorescent Biosensor Reveals Differential Subcellular Regulation of PKC. Nat. Chem. Biol. 21, 501-511 (2025) (#Co-second authors)
6. Gest, A., Sahan, A. Z., Zhong, Y., Lin, W., Mehta, S. and Zhang, J. Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals. Chem. Rev. 124(22):12573-12660 (2024).
7. Lin, W.#, Mo, G.C.H.#, Mehta, S. and Zhang, J. DrFLINC Contextualizes Super-resolution Activity Imaging. J. Am. Chem. Soc. 143, 37, 14951-14955 (2021). (#Co-first authors)
8. Zhang, JF., Liu, B., Hong, I., Mo, A., Roth, R.H., Tenner, B., Lin, W., Zhang, J.Z., Molina, R.S., Drobizhev, M., Hughes, T.E., Tian, L., Huganir, R.L., Mehta, S. and Zhang, J. An Ultrasensitive Biosensor for High-resolution Kinase Activity Imaging in Awake Mice. Nat. Chem. Biol. 17, 39–46 (2021).
9. Lin, W., Mehta, S. and Zhang, J. Genetically Encoded Fluorescent Biosensors Illuminate Kinase Signaling in Cancer. J. Biol. Chem. 294(40): 14814-14822 (2019).

@ Peking University
10. Sun, X., Chen, Y., Yang, C., Yang, S., Lin, W., Quan, B., Ding, Q., Chen, X., Wang, C., and Qin, W. Chemical Recording of Pump-Specific Drug Efflux in Living Cells. Angew. Chem. Int. Ed. 63: e202409282 (2024).
11. Xu, Y., Peng, L., Wang, S., Wang, A., Ma, R., Zhou, Y., Yang, J., Sun, D., Lin, W., Chen, X. and Zou, P. Hybrid Indicators for Fast and Sensitive Voltage Imaging. Angew. Chem. Int. Ed. 57(15): 3949-3953 (2018)
12. Lin, W., Gao, L., Qin, K. and Chen, X. in Chemical Biology of Glycoproteins, ed. Tan, Z. and Wang, L., The Royal Society of Chemistry, Cambridge, 2017, p. 280-297. [Book chapter]
13. Lin, W., Gao, L. and Chen, X. Protein-Specific Imaging of O-GlcNAcylation in Single Cells. ChemBioChem. 16, 2571-2575 (2015). [Cover paper]
14. Lin, W., Gao, L. and Chen, X. Protein-Specific Imaging of Posttranslational Modifications. Curr. Opin. Chem. Biol. 28, 156-163 (2015).
15. Lin, L., Liu, L., Zhao, B., Xie, R., Lin, W., Li, H., Shi, M., Chen, Y., Springer, T. A. and Chen, X. Carbon Nanotube-Assisted Optical Activation of TGF-β Signaling by Near-Infrared Light. Nature Nanotech. 10, 465-471 (2015).
16. Yang, Y., Lin, S., Lin, W. and Chen, R. P. Ligand-Assisted Dual-Site Click Labeling of EGFR on Living Cells. ChemBioChem. 15(12): 1738-43 (2014).
17. Lin, W., Du, Y., Zhu, Y. and Chen, X. A Cis-Membrane FRET-Based Method for Protein-Specific Imaging of Cell-Surface Glycans. J. Am. Chem. Soc. 136, 679-687 (2014). [The first article in Editors’ Choice program; Featured in Chemical & Engineering News 2014, 92(1), 10]

@ Tianjin University
18. Jiang, L., Cao, C., Zhang, L., Lin, W., Xia, J., Xu, H. and Zhang, Y. Cadmium-induced activation of high osmolarity glycerol pathway through its Sln1 branch is dependent on the MAP kinase kinase kinase Ssk2, but not its paralog Ssk22, in budding yeast. FEMS Yeast Res. 14(8): 1263-1272 (2014).
19. Zhao, J., Lin, W., Ma, X., Lu, Q., Ma, X., Bian, G. and Jiang, L. The protein kinase Hal5p is the high-copy suppressor of lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as the ergosterol biosynthesis in Saccharomyces cerevisiae. Genomics. 95(5): 290-298 (2010).