生物医药

以高分子化学为基础，综合高分子化学与物理、材料学、生物医药等多学科交叉的前沿学术研究，开展包括高分子的设计与合成、自组装及其功能化、生物活性多肽的设计与筛选、智能药物缓控释体系、逆转肿瘤耐药纳米材料、抗耐药菌活性纳米材料等多方面的研究。

1. Bu, Z. H.; Jing, J. X.; Liu, W.; Fan, Z.; Huang, J. C.; Zhou, Z.; Hu, J. H.; An J. X.; Hong, J. C.; Yu, J. N.; Tang, D. L.; Sun, M.*; Du J. Z.*; Wu P.*, Treatment of Denervated Muscle Atrophy by Injectable Dual-Responsive Hydrogels Loaded with Extracellular Vesicles. Advanced Science 2025, 10.1002/advs.202412248.
2. Sun, M.; He, L.; Chen, R.; Lv, M. C.; Chen, Z. S.; Fan, Z.; Zhou, Y. X.*; Qin, J. L.*; Du, J. Z.*, Rational design of peptides to overcome drug resistance by metabolic regulation. Drug Resistance Updates 2025, 79, 101208.
3. He, L.; Meng, F. Y.; Chen, Y.; Qin, J. L.; Sun, M.*; Fan, Z.*; Du, J. Z.*, Precise Regulations at the Subcellular Level through Intracellular Polymerization, Assembly, and Transformation. JACS Au 2024, 4, 4162-4186.
4. Sun, M.; Tao, Y.; Wang, C. Y.; Fan, Z.*; Ehud Gazit*; Du, J. Z.*, Ultrasound-Responsive Peptide Nanogels to Balance Conflicting Requirements for Deep Tumor Penetration and Prolonged Blood Circulation. ACS Nano 2022, 16, 9183-9194.
5. Sun, M.; Wang, C. Y.; Lv, M. C.; Fan, Z.*; Du, J. Z.*, Intracellular Self-Assembly of Peptides to Induce Apoptosis against Drug-Resistant Melanoma, Journal of the American Chemical Society 2022, 144, 7337.
6. Sun, M.; Ji. Z. K.; He, L.; Zhao, C. Z.; Ma, L.; Xu, X. Z.; Cornel, E. J.; Fan, Z.*; Xu, X. B.*, Instant Intracellular Delivery of miRNA via Photothermal Effect Induced on Plasmonic Pyramid Arrays, Advanced Functional Materials 2022, 32, 2107999.
7. Sun, M.; Wang, C. Y.; Lv, M. C.; Fan, Z.*; Du, J. Z.*, Mitochondrial-targeting nanoprodrugs to mutually reinforce metabolic inhibition and autophagy for combating resistant cancer, Biomaterials 2021, 278, 121168.
8. Sun, M.; He, L.; Fan, Z.*; Tang, R. P.*; Du, J. Z.*, Effective treatment of drug-resistant lung cancer via a nanogel capable of reactivating cisplatin and enhancing early apoptosis, Biomaterials 2020, 257, 120252.